Clinical features of elderly-onset Adult-onset Still's disease
To clarify the characteristics of patients with elderly-onset Adult-onset Still's disease (AOSD). Patients were classified into elderly-onset (>60 years: 47 patients) and younger-onset (≤60 years: 95 patients) groups according to their age at diagnosis of AOSD. Clinical features, treatments,...
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| Veröffentlicht in: | Modern rheumatology 2021-07, Vol.31 (4), p.862-868 |
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| container_title | Modern rheumatology |
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| creator | Maruyama, Akihito Kokuzawa, Ayako Yamauchi, Yusuke Kirino, Yohei Nagai, Hideto Inoue, Yasushi Ota, Toshiyuki Chifu, Yutaka Inokuchi, Satomi Koarada, Syuichi Ohta, Akihide Iwamoto, Masahiro Tada, Yoshifumi |
| description | To clarify the characteristics of patients with elderly-onset Adult-onset Still's disease (AOSD).
Patients were classified into elderly-onset (>60 years: 47 patients) and younger-onset (≤60 years: 95 patients) groups according to their age at diagnosis of AOSD. Clinical features, treatments, and prognosis were compared between the elderly-onset and younger-onset groups.
In the elderly-onset group, compared with the younger-onset group, typical skin rashes were less frequent (21.3% vs 58.9%, respectively; p |
| doi_str_mv | 10.1080/14397595.2020.1829340 |
| format | Article |
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Patients were classified into elderly-onset (>60 years: 47 patients) and younger-onset (≤60 years: 95 patients) groups according to their age at diagnosis of AOSD. Clinical features, treatments, and prognosis were compared between the elderly-onset and younger-onset groups.
In the elderly-onset group, compared with the younger-onset group, typical skin rashes were less frequent (21.3% vs 58.9%, respectively; p < .0001), whereas pleuritis (27.7% vs 7.4%, respectively; p = .0011) and disseminated intravascular coagulation (19.1% vs 2.1%, respectively; p = .0004) were more frequent, and serum ferritin levels were higher (median 12,700 ng/ml vs 2526 ng/ml, respectively; p < .0001). Overall survival and AOSD-related survival were reduced (p = .0006 and p = .0023, respectively) and drug-free remission was less frequent (p = .0035) in the elderly-onset group compared with the younger-onset group.
Our results demonstrated that elderly-onset AOSD patients had several characteristics that differed from younger-onset AOSD patients, including less typical skin lesions, more AOSD-related complications, higher ferritin levels, and poorer prognoses.</description><identifier>ISSN: 1439-7595</identifier><identifier>EISSN: 1439-7609</identifier><identifier>DOI: 10.1080/14397595.2020.1829340</identifier><identifier>PMID: 32990106</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adult ; Adult-onset Still's disease ; Age Factors ; Age of Onset ; Aged ; complication ; elderly-onset ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; remission ; Still's Disease, Adult-Onset - diagnosis ; Still's Disease, Adult-Onset - pathology</subject><ispartof>Modern rheumatology, 2021-07, Vol.31 (4), p.862-868</ispartof><rights>2020 Japan College of Rheumatology 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-72c14cf206ec048858a2d992a16f323b185601175b9180fdd59a77986bf167fc3</citedby><cites>FETCH-LOGICAL-c456t-72c14cf206ec048858a2d992a16f323b185601175b9180fdd59a77986bf167fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32990106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maruyama, Akihito</creatorcontrib><creatorcontrib>Kokuzawa, Ayako</creatorcontrib><creatorcontrib>Yamauchi, Yusuke</creatorcontrib><creatorcontrib>Kirino, Yohei</creatorcontrib><creatorcontrib>Nagai, Hideto</creatorcontrib><creatorcontrib>Inoue, Yasushi</creatorcontrib><creatorcontrib>Ota, Toshiyuki</creatorcontrib><creatorcontrib>Chifu, Yutaka</creatorcontrib><creatorcontrib>Inokuchi, Satomi</creatorcontrib><creatorcontrib>Koarada, Syuichi</creatorcontrib><creatorcontrib>Ohta, Akihide</creatorcontrib><creatorcontrib>Iwamoto, Masahiro</creatorcontrib><creatorcontrib>Tada, Yoshifumi</creatorcontrib><title>Clinical features of elderly-onset Adult-onset Still's disease</title><title>Modern rheumatology</title><addtitle>Mod Rheumatol</addtitle><description>To clarify the characteristics of patients with elderly-onset Adult-onset Still's disease (AOSD).
Patients were classified into elderly-onset (>60 years: 47 patients) and younger-onset (≤60 years: 95 patients) groups according to their age at diagnosis of AOSD. Clinical features, treatments, and prognosis were compared between the elderly-onset and younger-onset groups.
In the elderly-onset group, compared with the younger-onset group, typical skin rashes were less frequent (21.3% vs 58.9%, respectively; p < .0001), whereas pleuritis (27.7% vs 7.4%, respectively; p = .0011) and disseminated intravascular coagulation (19.1% vs 2.1%, respectively; p = .0004) were more frequent, and serum ferritin levels were higher (median 12,700 ng/ml vs 2526 ng/ml, respectively; p < .0001). Overall survival and AOSD-related survival were reduced (p = .0006 and p = .0023, respectively) and drug-free remission was less frequent (p = .0035) in the elderly-onset group compared with the younger-onset group.
Our results demonstrated that elderly-onset AOSD patients had several characteristics that differed from younger-onset AOSD patients, including less typical skin lesions, more AOSD-related complications, higher ferritin levels, and poorer prognoses.</description><subject>Adult</subject><subject>Adult-onset Still's disease</subject><subject>Age Factors</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>complication</subject><subject>elderly-onset</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>remission</subject><subject>Still's Disease, Adult-Onset - diagnosis</subject><subject>Still's Disease, Adult-Onset - pathology</subject><issn>1439-7595</issn><issn>1439-7609</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKw0AUhgdRrFYfQclON6lzydw2YineoOBCXQ-TucDIJKkzCdK3N6WpS1fn8POd88MHwBWCCwQFvEMVkZxKusAQj5HAklTwCJzt8pIzKI8P-wjNwHnOXxASKoU8BTOCpYQIsjNwv4qhDUbHwjvdD8nlovOFi9aluC27Nru-WNoh9tP-3ocYb3JhQ3Y6uwtw4nXM7nKac_D59PixeinXb8-vq-W6NBVlfcmxQZXxGDJnYCUEFRpbKbFGzBNMaiQogwhxWkskoLeWSs25FKz2iHFvyBzc7v9uUvc9uNyrJmTjYtSt64ascFVxgiBleETpHjWpyzk5rzYpNDptFYJqp04d1KmdOjWpG--up4qhbpz9uzq4GoGHPRBa36VG_3QpWtXrbeyST7o1ISvyf8cvHUp7tg</recordid><startdate>20210704</startdate><enddate>20210704</enddate><creator>Maruyama, Akihito</creator><creator>Kokuzawa, Ayako</creator><creator>Yamauchi, Yusuke</creator><creator>Kirino, Yohei</creator><creator>Nagai, Hideto</creator><creator>Inoue, Yasushi</creator><creator>Ota, Toshiyuki</creator><creator>Chifu, Yutaka</creator><creator>Inokuchi, Satomi</creator><creator>Koarada, Syuichi</creator><creator>Ohta, Akihide</creator><creator>Iwamoto, Masahiro</creator><creator>Tada, Yoshifumi</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20210704</creationdate><title>Clinical features of elderly-onset Adult-onset Still's disease</title><author>Maruyama, Akihito ; Kokuzawa, Ayako ; Yamauchi, Yusuke ; Kirino, Yohei ; Nagai, Hideto ; Inoue, Yasushi ; Ota, Toshiyuki ; Chifu, Yutaka ; Inokuchi, Satomi ; Koarada, Syuichi ; Ohta, Akihide ; Iwamoto, Masahiro ; Tada, Yoshifumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-72c14cf206ec048858a2d992a16f323b185601175b9180fdd59a77986bf167fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Adult-onset Still's disease</topic><topic>Age Factors</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>complication</topic><topic>elderly-onset</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>remission</topic><topic>Still's Disease, Adult-Onset - diagnosis</topic><topic>Still's Disease, Adult-Onset - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maruyama, Akihito</creatorcontrib><creatorcontrib>Kokuzawa, Ayako</creatorcontrib><creatorcontrib>Yamauchi, Yusuke</creatorcontrib><creatorcontrib>Kirino, Yohei</creatorcontrib><creatorcontrib>Nagai, Hideto</creatorcontrib><creatorcontrib>Inoue, Yasushi</creatorcontrib><creatorcontrib>Ota, Toshiyuki</creatorcontrib><creatorcontrib>Chifu, Yutaka</creatorcontrib><creatorcontrib>Inokuchi, Satomi</creatorcontrib><creatorcontrib>Koarada, Syuichi</creatorcontrib><creatorcontrib>Ohta, Akihide</creatorcontrib><creatorcontrib>Iwamoto, Masahiro</creatorcontrib><creatorcontrib>Tada, Yoshifumi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Modern rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maruyama, Akihito</au><au>Kokuzawa, Ayako</au><au>Yamauchi, Yusuke</au><au>Kirino, Yohei</au><au>Nagai, Hideto</au><au>Inoue, Yasushi</au><au>Ota, Toshiyuki</au><au>Chifu, Yutaka</au><au>Inokuchi, Satomi</au><au>Koarada, Syuichi</au><au>Ohta, Akihide</au><au>Iwamoto, Masahiro</au><au>Tada, Yoshifumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical features of elderly-onset Adult-onset Still's disease</atitle><jtitle>Modern rheumatology</jtitle><addtitle>Mod Rheumatol</addtitle><date>2021-07-04</date><risdate>2021</risdate><volume>31</volume><issue>4</issue><spage>862</spage><epage>868</epage><pages>862-868</pages><issn>1439-7595</issn><eissn>1439-7609</eissn><abstract>To clarify the characteristics of patients with elderly-onset Adult-onset Still's disease (AOSD).
Patients were classified into elderly-onset (>60 years: 47 patients) and younger-onset (≤60 years: 95 patients) groups according to their age at diagnosis of AOSD. Clinical features, treatments, and prognosis were compared between the elderly-onset and younger-onset groups.
In the elderly-onset group, compared with the younger-onset group, typical skin rashes were less frequent (21.3% vs 58.9%, respectively; p < .0001), whereas pleuritis (27.7% vs 7.4%, respectively; p = .0011) and disseminated intravascular coagulation (19.1% vs 2.1%, respectively; p = .0004) were more frequent, and serum ferritin levels were higher (median 12,700 ng/ml vs 2526 ng/ml, respectively; p < .0001). Overall survival and AOSD-related survival were reduced (p = .0006 and p = .0023, respectively) and drug-free remission was less frequent (p = .0035) in the elderly-onset group compared with the younger-onset group.
Our results demonstrated that elderly-onset AOSD patients had several characteristics that differed from younger-onset AOSD patients, including less typical skin lesions, more AOSD-related complications, higher ferritin levels, and poorer prognoses.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>32990106</pmid><doi>10.1080/14397595.2020.1829340</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Adult-onset Still's disease Age Factors Age of Onset Aged complication elderly-onset Female Humans Male Middle Aged Prognosis remission Still's Disease, Adult-Onset - diagnosis Still's Disease, Adult-Onset - pathology |
| title | Clinical features of elderly-onset Adult-onset Still's disease |
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