miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis

MicroRNA-29a (miR-29a) has been shown to ameliorate hepatocellular damage, such as in the context of non-alcoholic fatty liver disease (NAFLD), steatohepatitis (NASH), and cholestatic injury. However, the mechanism mediating the hepatoprotective effect of miR-29a in diet-induced NASH remains elusive...

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Veröffentlicht in:	International journal of molecular sciences 2020-09, Vol.21 (18), p.6884
Hauptverfasser:	Yang, Ya-Ling, Wang, Pei-Wen, Wang, Feng-Sheng, Lin, Hung-Yu, Huang, Ying-Hsien
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism GSK3β liver fibrosis Mice Mice, Transgenic microRNA-29a MicroRNAs - biosynthesis MicroRNAs - genetics Mitochondria, Liver - genetics Mitochondria, Liver - metabolism Mitochondria, Liver - pathology NASH Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Non-alcoholic Fatty Liver Disease - prevention & control Proteostasis proteostatic stress SIRT1 Sirtuin 1 - genetics Sirtuin 1 - metabolism Unfolded Protein Response
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