Efficacy of theobromine in preventing intestinal CaCo-2 cell damage induced by oxysterols

The alteration of the intestinal barrier function is currently believed to be involved in the pathogenesis of gut diseases mainly associated with the activation of inflammation processes. Diet plays an important role in the control of human gut integrity. Theobromine is a natural methylxanthine pres...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2020-11, Vol.694, p.108591, Article 108591
Hauptverfasser:	Iaia, Noemi, Rossin, Daniela, Sottero, Barbara, Venezia, Ivana, Poli, Giuseppe, Biasi, Fiorella
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - pharmacology Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism bcl-X Protein - metabolism Caco-2 Cells Dietary oxysterols Humans Intercellular Signaling Peptides and Proteins - metabolism Intestinal inflammation Matrix metalloproteinases Oxysterols - toxicity Protective Agents - pharmacology Theobromine Theobromine - pharmacology Tight junctions Tight Junctions - drug effects
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