Stable human regulatory T cells switch to glycolysis following TNF receptor 2 costimulation

Following activation, conventional T (T conv ) cells undergo an mTOR-driven glycolytic switch. Regulatory T (T reg ) cells reportedly repress the mTOR pathway and avoid glycolysis. However, here we demonstrate that human thymus-derived T reg (tT reg ) cells can become glycolytic in response to tumou...

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Veröffentlicht in:	Nature metabolism 2020-10, Vol.2 (10), p.1046-1061
Hauptverfasser:	de Kivit, Sander, Mensink, Mark, Hoekstra, Anna T., Berlin, Ilana, Derks, Rico J. E., Both, Demi, Aslam, Muhammad A., Amsen, Derk, Berkers, Celia R., Borst, Jannie
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/250/2152 631/443/319 631/45/320 Biomedical and Life Sciences CD3 Complex - metabolism Citric Acid Cycle - drug effects Endocrinology & Metabolism Glucose - metabolism Glucose - pharmacology Glycolysis - drug effects Humans Lactic Acid - blood Lactic Acid - metabolism Life Sciences Life Sciences & Biomedicine Metabolome Phosphatidylinositol 3-Kinases - metabolism Receptors, Tumor Necrosis Factor, Type II - drug effects Receptors, Tumor Necrosis Factor, Type II - metabolism RNA - chemistry Science & Technology Sequence Analysis, RNA Signal Transduction T-Lymphocytes, Regulatory - metabolism TOR Serine-Threonine Kinases - metabolism
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