Activation of voltage-gated sodium channels by BmK NT1 augments NMDA receptor function through Src family kinase signaling pathway in primary cerebellar granule cell cultures

Voltage-gated sodium channels (VGSCs) are responsible for the generation and propagation of action potentials in excitable cells and are the molecular targets of an array of neurotoxins. BmK NT1, an α-scorpion toxin obtained from the scorpion Buthus martensii Karsch (BmK), produces neurotoxicity tha...

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Veröffentlicht in:	Neuropharmacology 2020-12, Vol.180, p.108291, Article 108291
Hauptverfasser:	Zou, Xiaohan, He, Yuwei, Shen, Liping, Xi, Chuchu, He, Jing, Zhang, Fan, Zhao, Fang, Cao, Zhengyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology NMDA receptors Pharmacology & Pharmacy Science & Technology Trafficking Voltage-gated sodium channels α-Scorpion toxin
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