Redox modification of ryanodine receptor contributes to impaired Ca 2+ homeostasis and exacerbates muscle atrophy under high altitude

At extreme altitude, prolonged and severe hypoxia menaces human function and survival, and also associated with profound loss of muscle mass which results into a debilitating critical illness of skeletal muscle atrophy. Hypobaric hypoxia altered redox homeostasis and impaired calcium ion handling in...

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Veröffentlicht in:	Free radical biology & medicine 2020-11, Vol.160, p.643
Hauptverfasser:	Agrawal, Akanksha, Rathor, Richa, Kumar, Ravi, Suryakumar, Geetha, Singh, Som Nath, Kumar, Bhuvnesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Altitude Animals Calcium - metabolism Homeostasis Muscle, Skeletal - metabolism Muscular Atrophy - metabolism Oxidation-Reduction Rats Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - metabolism
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