A small molecular compound CC1007 induces cross-lineage differentiation by inhibiting HDAC7 expression and HDAC7/MEF2C interaction in BCR-ABL1− pre-B-ALL

Histone deacetylase 7 (HDAC7), a member of class IIa HDACs, has been described to be an important regulator for B cell development and has a potential role in B cell acute lymphoblastic leukemia (B-ALL). CC1007, a BML-210 analog, is designed to indirectly inhibit class IIa HDACs by binding to myocyt...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell death & disease 2020-09, Vol.11 (9), p.738-738, Article 738
Hauptverfasser:	Wang, Zhihua, Zhang, Yang, Zhu, Shicong, Peng, Hongling, Chen, Yongheng, Cheng, Zhao, Liu, Sufang, Luo, Yunya, Li, Ruijuan, Deng, Mingyang, Xu, Yunxiao, Hu, Guoyu, Chen, Lin, Zhang, Guangsen
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 13/2 13/31 13/89 13/95 14/19 14/34 14/5 14/63 38 45/15 631/67/1990/283/2125 64/60 692/308/575 82 82/80 Acute lymphoblastic leukemia Animals Antibodies Apoptosis BCR-ABL protein Biochemistry Biomedical and Life Sciences Bone marrow Cell Biology Cell Culture Cell Differentiation Cell fusion Cell Lineage Cell proliferation Fusion protein Histone deacetylase Histone Deacetylases - metabolism Humans Immunology Life Sciences Life Sciences & Biomedicine Lymphatic leukemia Macrophages Mice Monocytes Myocyte enhancer factor 2 Myocytes Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Science & Technology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!