Assessment of extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneumonia detected on 18 F-FDG PET-CT studies
Lung involvement in patients with coronavirus disease 2019 (COVID-19) undergoing PET-CT has been previously reported. However, FDG uptake outside lung parenchyma was poorly characterized in detail. We evaluated the extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneu...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2021-03, Vol.48 (3), p.768 |
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| creator | Wakfie-Corieh, Cristina Gamila Blanes García, Alba María Ferrando-Castagnetto, Federico Valhondo-Rama, Raquel Ortega Candil, Aida Rodríguez Rey, Cristina Cabrera Martín, María Nieves García-Esquinas, Marta García Couto Caro, Rosa María Pedrera Canal, María Carreras Delgado, José Luis |
| description | Lung involvement in patients with coronavirus disease 2019 (COVID-19) undergoing PET-CT has been previously reported. However, FDG uptake outside lung parenchyma was poorly characterized in detail. We evaluated the extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneumonia through
F-FDG PET-CT.
A total of 1079 oncologic
F-FDG PET-CT were performed between February 2 and May 18, 2020. Confirmed COVID-19 pneumonia was defined as characteristic ground-glass bilateral CT infiltrates and positive genetic/serologic tests. Nonmetastatic extra-parenchymal lung PET-CT findings were evaluated through qualitative (visual), quantitative (measurements on CT), and semiquantitative (maximum standardized uptake value: SUVmax on PET) interpretation. Clinical data, blood tests, and PET-CT results were compared between patients with and without COVID-19 pneumonia.
A total of 23
F-FDG PET-CT scans with pulmonary infiltrates suggestive of COVID-19 and available laboratory data were included: 14 positive (cases) and 9 negative (controls) for COVID-19 infection, representing a low prevalence of COVID-19 pneumonia (1.3%). Serum lactate dehydrogenase and D-dimers tended to be increased in COVID-19 cases. Extra-parenchymal lung findings were found in 42.9% of patients with COVID-19, most frequently as mediastinal and hilar nodes with
F-FDG uptake (35.7%), followed by incidental pulmonary embolism in two patients (14.3%). In the control group, extra-pulmonary findings were observed in a single patient (11.1%) with
F-FDG uptake located to mediastinal, hilar, and cervical nodes. Nasopharyngeal and hepatic SUVmax were similar in both groups.
In cancer patients with asymptomatic COVID-19 pneumonia,
F-FDG PET-CT findings are more frequently limited to thoracic structures, suggesting that an early and silent distant involvement is very rare. Pulmonary embolism is a frequent and potentially severe finding raising special concern. PET-CT can provide new pathogenic insights about this novel disease. |
| format | Article |
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F-FDG PET-CT.
A total of 1079 oncologic
F-FDG PET-CT were performed between February 2 and May 18, 2020. Confirmed COVID-19 pneumonia was defined as characteristic ground-glass bilateral CT infiltrates and positive genetic/serologic tests. Nonmetastatic extra-parenchymal lung PET-CT findings were evaluated through qualitative (visual), quantitative (measurements on CT), and semiquantitative (maximum standardized uptake value: SUVmax on PET) interpretation. Clinical data, blood tests, and PET-CT results were compared between patients with and without COVID-19 pneumonia.
A total of 23
F-FDG PET-CT scans with pulmonary infiltrates suggestive of COVID-19 and available laboratory data were included: 14 positive (cases) and 9 negative (controls) for COVID-19 infection, representing a low prevalence of COVID-19 pneumonia (1.3%). Serum lactate dehydrogenase and D-dimers tended to be increased in COVID-19 cases. Extra-parenchymal lung findings were found in 42.9% of patients with COVID-19, most frequently as mediastinal and hilar nodes with
F-FDG uptake (35.7%), followed by incidental pulmonary embolism in two patients (14.3%). In the control group, extra-pulmonary findings were observed in a single patient (11.1%) with
F-FDG uptake located to mediastinal, hilar, and cervical nodes. Nasopharyngeal and hepatic SUVmax were similar in both groups.
In cancer patients with asymptomatic COVID-19 pneumonia,
F-FDG PET-CT findings are more frequently limited to thoracic structures, suggesting that an early and silent distant involvement is very rare. Pulmonary embolism is a frequent and potentially severe finding raising special concern. PET-CT can provide new pathogenic insights about this novel disease.</description><identifier>EISSN: 1619-7089</identifier><identifier>PMID: 32901353</identifier><language>eng</language><publisher>Germany</publisher><subject>Common Bile Duct Neoplasms ; COVID-19 - complications ; COVID-19 - diagnostic imaging ; COVID-19 - epidemiology ; COVID-19 Testing ; Female ; Fluorodeoxyglucose F18 - administration & dosage ; Humans ; Lung - diagnostic imaging ; Male ; Neoplasms - diagnostic imaging ; Pneumonia - complications ; Pneumonia - diagnostic imaging ; Positron Emission Tomography Computed Tomography - methods ; Radiopharmaceuticals - administration & dosage ; SARS-CoV-2</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2021-03, Vol.48 (3), p.768</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-8887-405X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32901353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wakfie-Corieh, Cristina Gamila</creatorcontrib><creatorcontrib>Blanes García, Alba María</creatorcontrib><creatorcontrib>Ferrando-Castagnetto, Federico</creatorcontrib><creatorcontrib>Valhondo-Rama, Raquel</creatorcontrib><creatorcontrib>Ortega Candil, Aida</creatorcontrib><creatorcontrib>Rodríguez Rey, Cristina</creatorcontrib><creatorcontrib>Cabrera Martín, María Nieves</creatorcontrib><creatorcontrib>García-Esquinas, Marta García</creatorcontrib><creatorcontrib>Couto Caro, Rosa María</creatorcontrib><creatorcontrib>Pedrera Canal, María</creatorcontrib><creatorcontrib>Carreras Delgado, José Luis</creatorcontrib><title>Assessment of extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneumonia detected on 18 F-FDG PET-CT studies</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>Lung involvement in patients with coronavirus disease 2019 (COVID-19) undergoing PET-CT has been previously reported. However, FDG uptake outside lung parenchyma was poorly characterized in detail. We evaluated the extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneumonia through
F-FDG PET-CT.
A total of 1079 oncologic
F-FDG PET-CT were performed between February 2 and May 18, 2020. Confirmed COVID-19 pneumonia was defined as characteristic ground-glass bilateral CT infiltrates and positive genetic/serologic tests. Nonmetastatic extra-parenchymal lung PET-CT findings were evaluated through qualitative (visual), quantitative (measurements on CT), and semiquantitative (maximum standardized uptake value: SUVmax on PET) interpretation. Clinical data, blood tests, and PET-CT results were compared between patients with and without COVID-19 pneumonia.
A total of 23
F-FDG PET-CT scans with pulmonary infiltrates suggestive of COVID-19 and available laboratory data were included: 14 positive (cases) and 9 negative (controls) for COVID-19 infection, representing a low prevalence of COVID-19 pneumonia (1.3%). Serum lactate dehydrogenase and D-dimers tended to be increased in COVID-19 cases. Extra-parenchymal lung findings were found in 42.9% of patients with COVID-19, most frequently as mediastinal and hilar nodes with
F-FDG uptake (35.7%), followed by incidental pulmonary embolism in two patients (14.3%). In the control group, extra-pulmonary findings were observed in a single patient (11.1%) with
F-FDG uptake located to mediastinal, hilar, and cervical nodes. Nasopharyngeal and hepatic SUVmax were similar in both groups.
In cancer patients with asymptomatic COVID-19 pneumonia,
F-FDG PET-CT findings are more frequently limited to thoracic structures, suggesting that an early and silent distant involvement is very rare. Pulmonary embolism is a frequent and potentially severe finding raising special concern. PET-CT can provide new pathogenic insights about this novel disease.</description><subject>Common Bile Duct Neoplasms</subject><subject>COVID-19 - complications</subject><subject>COVID-19 - diagnostic imaging</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 Testing</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18 - administration & dosage</subject><subject>Humans</subject><subject>Lung - diagnostic imaging</subject><subject>Male</subject><subject>Neoplasms - diagnostic imaging</subject><subject>Pneumonia - complications</subject><subject>Pneumonia - diagnostic imaging</subject><subject>Positron Emission Tomography Computed Tomography - methods</subject><subject>Radiopharmaceuticals - administration & dosage</subject><subject>SARS-CoV-2</subject><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjk1OwzAQRi0k1BbKFdBcwFLcqCVeorSBrmARsa0GZ0qN4h95nELuwKFbIVh39enpvcV3JWZqpbR8KCo9FTfMn0WhqkWlJ2JaLnShymU5Ez-PzMTsyGcIe6DvnFBGTOTNYXTYQz_4D7D-GPoj_VbWA_LoYg4OszVg0BtKEM9w1gxfNh-gfnnbrqXSED0NLniL0FEmk6mD4EFV0Mhm_QSvm1bWLXAeOks8F9d77Jnu_vZW3Debtn6WcXh31O1isg7TuPu_X14MTteQUQA</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Wakfie-Corieh, Cristina Gamila</creator><creator>Blanes García, Alba María</creator><creator>Ferrando-Castagnetto, Federico</creator><creator>Valhondo-Rama, Raquel</creator><creator>Ortega Candil, Aida</creator><creator>Rodríguez Rey, Cristina</creator><creator>Cabrera Martín, María Nieves</creator><creator>García-Esquinas, Marta García</creator><creator>Couto Caro, Rosa María</creator><creator>Pedrera Canal, María</creator><creator>Carreras Delgado, José Luis</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0001-8887-405X</orcidid></search><sort><creationdate>202103</creationdate><title>Assessment of extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneumonia detected on 18 F-FDG PET-CT studies</title><author>Wakfie-Corieh, Cristina Gamila ; Blanes García, Alba María ; Ferrando-Castagnetto, Federico ; Valhondo-Rama, Raquel ; Ortega Candil, Aida ; Rodríguez Rey, Cristina ; Cabrera Martín, María Nieves ; García-Esquinas, Marta García ; Couto Caro, Rosa María ; Pedrera Canal, María ; Carreras Delgado, José Luis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_329013533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Common Bile Duct Neoplasms</topic><topic>COVID-19 - complications</topic><topic>COVID-19 - diagnostic imaging</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 Testing</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18 - administration & dosage</topic><topic>Humans</topic><topic>Lung - diagnostic imaging</topic><topic>Male</topic><topic>Neoplasms - diagnostic imaging</topic><topic>Pneumonia - complications</topic><topic>Pneumonia - diagnostic imaging</topic><topic>Positron Emission Tomography Computed Tomography - methods</topic><topic>Radiopharmaceuticals - administration & dosage</topic><topic>SARS-CoV-2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wakfie-Corieh, Cristina Gamila</creatorcontrib><creatorcontrib>Blanes García, Alba María</creatorcontrib><creatorcontrib>Ferrando-Castagnetto, Federico</creatorcontrib><creatorcontrib>Valhondo-Rama, Raquel</creatorcontrib><creatorcontrib>Ortega Candil, Aida</creatorcontrib><creatorcontrib>Rodríguez Rey, Cristina</creatorcontrib><creatorcontrib>Cabrera Martín, María Nieves</creatorcontrib><creatorcontrib>García-Esquinas, Marta García</creatorcontrib><creatorcontrib>Couto Caro, Rosa María</creatorcontrib><creatorcontrib>Pedrera Canal, María</creatorcontrib><creatorcontrib>Carreras Delgado, José Luis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wakfie-Corieh, Cristina Gamila</au><au>Blanes García, Alba María</au><au>Ferrando-Castagnetto, Federico</au><au>Valhondo-Rama, Raquel</au><au>Ortega Candil, Aida</au><au>Rodríguez Rey, Cristina</au><au>Cabrera Martín, María Nieves</au><au>García-Esquinas, Marta García</au><au>Couto Caro, Rosa María</au><au>Pedrera Canal, María</au><au>Carreras Delgado, José Luis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneumonia detected on 18 F-FDG PET-CT studies</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2021-03</date><risdate>2021</risdate><volume>48</volume><issue>3</issue><spage>768</spage><pages>768-</pages><eissn>1619-7089</eissn><abstract>Lung involvement in patients with coronavirus disease 2019 (COVID-19) undergoing PET-CT has been previously reported. However, FDG uptake outside lung parenchyma was poorly characterized in detail. We evaluated the extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneumonia through
F-FDG PET-CT.
A total of 1079 oncologic
F-FDG PET-CT were performed between February 2 and May 18, 2020. Confirmed COVID-19 pneumonia was defined as characteristic ground-glass bilateral CT infiltrates and positive genetic/serologic tests. Nonmetastatic extra-parenchymal lung PET-CT findings were evaluated through qualitative (visual), quantitative (measurements on CT), and semiquantitative (maximum standardized uptake value: SUVmax on PET) interpretation. Clinical data, blood tests, and PET-CT results were compared between patients with and without COVID-19 pneumonia.
A total of 23
F-FDG PET-CT scans with pulmonary infiltrates suggestive of COVID-19 and available laboratory data were included: 14 positive (cases) and 9 negative (controls) for COVID-19 infection, representing a low prevalence of COVID-19 pneumonia (1.3%). Serum lactate dehydrogenase and D-dimers tended to be increased in COVID-19 cases. Extra-parenchymal lung findings were found in 42.9% of patients with COVID-19, most frequently as mediastinal and hilar nodes with
F-FDG uptake (35.7%), followed by incidental pulmonary embolism in two patients (14.3%). In the control group, extra-pulmonary findings were observed in a single patient (11.1%) with
F-FDG uptake located to mediastinal, hilar, and cervical nodes. Nasopharyngeal and hepatic SUVmax were similar in both groups.
In cancer patients with asymptomatic COVID-19 pneumonia,
F-FDG PET-CT findings are more frequently limited to thoracic structures, suggesting that an early and silent distant involvement is very rare. Pulmonary embolism is a frequent and potentially severe finding raising special concern. PET-CT can provide new pathogenic insights about this novel disease.</abstract><cop>Germany</cop><pmid>32901353</pmid><orcidid>https://orcid.org/0000-0001-8887-405X</orcidid></addata></record> |
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| ispartof | European journal of nuclear medicine and molecular imaging, 2021-03, Vol.48 (3), p.768 |
| issn | 1619-7089 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Common Bile Duct Neoplasms COVID-19 - complications COVID-19 - diagnostic imaging COVID-19 - epidemiology COVID-19 Testing Female Fluorodeoxyglucose F18 - administration & dosage Humans Lung - diagnostic imaging Male Neoplasms - diagnostic imaging Pneumonia - complications Pneumonia - diagnostic imaging Positron Emission Tomography Computed Tomography - methods Radiopharmaceuticals - administration & dosage SARS-CoV-2 |
| title | Assessment of extra-parenchymal lung involvement in asymptomatic cancer patients with COVID-19 pneumonia detected on 18 F-FDG PET-CT studies |
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