POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks

Interhomolog recombination (IHR) occurs spontaneously in somatic human cells at frequencies that are low but sufficient to ameliorate some genetic diseases caused by heterozygous mutations or autosomal dominant mutations. Here we demonstrate that DNA nicks or double-strand breaks (DSBs) targeted by...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-09, Vol.117 (37), p.22900-22909
Hauptverfasser:	Davis, Luther, Khoo, Kevin J., Zhang, Yinbo, Maizels, Nancy
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cell Line, Tumor Chemical compounds CRISPR CRISPR-Cas Systems Deoxyribonucleic acid Depletion DNA DNA Breaks, Double-Stranded DNA Breaks, Single-Stranded DNA damage DNA End-Joining Repair DNA Ligases - genetics DNA Ligases - metabolism DNA Polymerase theta DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Heterozygosity Heterozygote Homology Humans Loss of Heterozygosity Multidisciplinary Sciences Mutation Pharmacology Recombinants Recombination Recombination, Genetic Recombinational DNA Repair Science & Technology Science & Technology - Other Topics
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