Tandem Bioorthogonal Labeling Uncovers Endogenous Cotranslationally O‑GlcNAc Modified Nascent Proteins

Hundreds of nuclear, cytoplasmic, and mitochondrial proteins within multicellular eukaryotes have hydroxyl groups of specific serine and threonine residues modified by the monosaccharide N-acetylglucosamine (GlcNAc). This modification, known as O-GlcNAc, has emerged as a central regulator of both ce...

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Veröffentlicht in:	Journal of the American Chemical Society 2020-09, Vol.142 (37), p.15729-15739
Hauptverfasser:	Zhu, Yanping, Willems, Lianne I, Salas, Daniela, Cecioni, Samy, Wu, Weifeng B, Foster, Leonard J, Vocadlo, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - chemistry Acetylglucosamine - metabolism Chemistry Chemistry, Multidisciplinary HEK293 Cells Humans Metabolic Engineering Mitochondrial Proteins - chemistry Mitochondrial Proteins - metabolism Molecular Conformation Monosaccharides - chemistry Monosaccharides - metabolism Physical Sciences Science & Technology
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