Cryptotanshinone chemosensitivity potentiation by TW-37 in human oral cancer cell lines by targeting STAT3-Mcl-1 signaling

Background: Despite being one of the leading cancer types in the world, the diagnosis of oral cancer and its suitable therapeutic options remain limited. This study aims to investigate the single and chemosensitizing effects of TW-37, a BH3 mimetic in oral cancer, on human oral cancer cell lines. Me...

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Veröffentlicht in:	Cancer Cell International 2020-08, Vol.20 (1), p.405-405, Article 405
Hauptverfasser:	Yang, In-Hyoung, Hong, Seung-Hyun, Jung, Minjung, Ahn, Chi-Hyun, Yoon, Hye-Jung, Hong, Seong Doo, Cho, Sung-Dae, Shin, Ji-Ae
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Annexin V Antibodies Apoptosis Cancer research Cancer therapies Care and treatment Caspase Cell cycle Chemosensitivity Cloning Cryptotanshinone Cytotoxicity Ectopic expression Gene regulation Health aspects Leukemia Life Sciences & Biomedicine Mcl-1 Mcl-1 protein Medical prognosis Morphology Mouth cancer Nuclear transport Oncology Oral cancer Phosphorylation Post-translation Primary Research Proteins Science & Technology STAT3 Stat3 protein Transcription Transfection Tumor cell lines TW-37 Western blotting
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