Increasing cytochrome P450 enzyme diversity by identification of two distinct cyclodipeptide dimerases

Genome mining revealed the presence of two cdps-p 450 operons in Saccharopolyspora antimicrobica . Heterologous expression, biochemical characterisation and structure elucidation proved that the two P450 enzymes catalyse distinct regio- and stereospecific dimerizations of cyclo -( l -Trp- l -Trp), w...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2020-09, Vol.56 (75), p.1142-1145
Hauptverfasser:	Liu, Jing, Xie, Xiulan, Li, Shu-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochromes P450 Dimerization Enzymes Molecular Conformation Peptides, Cyclic - chemistry Peptides, Cyclic - genetics Peptides, Cyclic - metabolism Saccharopolyspora - enzymology
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