T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an alpha-synuclein rat model of Parkinson's disease

Background Parkinson's disease (PD) is the second most prevalent movement disorder characterized by up to 80% loss of dopamine (DA) neurons and accumulation of Lewy body deposits composed of alpha-synuclein (alpha-syn). Accumulation of alpha-syn is associated with microglial activation, leading...

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Veröffentlicht in:	Journal of neuroinflammation 2020-08, Vol.17 (1), p.242-242, Article 242
Hauptverfasser:	Subbarayan, Meena S., Hudson, Charles, Moss, Lauren D., Nash, Kevin R., Bickford, Paula C.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - genetics alpha-Synuclein - metabolism Animals Antibodies Antigen presentation Brain CD4 antigen CD8 antigen Cell activation Cell adhesion & migration Cells, Cultured Coding Cytokines Disease Disease Models, Animal Dopamine Dopamine receptors Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Immune system Immunology Infiltration Inflammation Injection Laboratory animals Lewy bodies Life Sciences & Biomedicine Lymphocytes Lymphocytes T Male Microglia Microglia - metabolism Microglia - pathology Movement disorders Neurodegeneration Neurodegenerative diseases Neuroinflammation Neurons Neurons - metabolism Neurons - pathology Neuroprotection Neurosciences Neurosciences & Neurology Neurotoxicity Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Pathogenesis Rats Rats, Nude Rodents Science & Technology Substantia nigra Substantia Nigra - metabolism Substantia Nigra - pathology Surgery Synuclein T cells T-Lymphocytes - metabolism T-Lymphocytes - pathology Up-Regulation α-synuclein
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