Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis

Increased hepatocyte death contributes to the pathology of acute and chronic liver diseases. However, the role of hepatocyte pyroptosis and extracellular inflammasome release in liver disease is unknown. We used primary mouse and human hepatocytes, hepatocyte-specific leucine 351 to proline Nlrp3KIC...

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Veröffentlicht in:	Journal of hepatology 2021-01, Vol.74 (1), p.156-167
Hauptverfasser:	Gaul, Susanne, Leszczynska, Aleksandra, Alegre, Fernando, Kaufmann, Benedikt, Johnson, Casey D., Adams, Leon A., Wree, Alexander, Damm, Georg, Seehofer, Daniel, Calvente, Carolina J., Povero, Davide, Kisseleva, Tatiana, Eguchi, Akiko, McGeough, Matthew D., Hoffman, Hal M., Pelegrin, Pablo, Laufs, Ulrich, Feldstein, Ariel E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animals ASC Biopsy Caspase 1 - metabolism Caspase-1 Cell activation Cell death Cytochalasin B Dosage Endocytosis Fatty liver Fibrosis Gastroenterology & Hepatology Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Hepatocytes Hepatocytes - metabolism Hepatocytes - pathology Humans IL-1β Inflammasome Inflammasomes Inflammasomes - metabolism Interleukin-1beta - metabolism Leucine Life Sciences & Biomedicine Lipopolysaccharides Liver Liver Cirrhosis - immunology Liver Cirrhosis - metabolism Liver diseases Mice Mice, Inbred NOD NASH NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Patients Proline Protein Translocation Systems - metabolism Pyrin protein Pyroptosis Pyroptosis - immunology Reactive Oxygen Species - metabolism Science & Technology Smooth muscle Specks Stellate cells
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