Chronic real-time particulate matter exposure causes rat pulmonary arteriole hyperresponsiveness and remodeling: The role of ET B R-ERK1/2 signaling

Exposure to air pollution is associated with the incidence of respiratory diseases. The present study evaluated the pulmonary vascular system injury by chronic real-time particulate matter (PM ) exposure and investigated the underlying mechanisms. Rats were exposed to PM or filtered air for 2 to 4 m...

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Veröffentlicht in:	Toxicology and applied pharmacology 2020-09, Vol.403, p.115154
Hauptverfasser:	Xiao, Xue, Yao, Tong, Du, Shuaishuai, Wang, Jin, Yan, Pinging, Lei, Yali, Cao, Lei, Shen, Zhenxing, Cao, Yongxiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterioles - drug effects Butadienes - pharmacology Drug Administration Schedule Endothelin-1 - genetics Endothelin-1 - metabolism Enzyme Inhibitors - pharmacology Gene Expression Regulation - drug effects Lung - blood supply MAP Kinase Kinase Kinases - antagonists & inhibitors Nitriles - pharmacology Particulate Matter - toxicity Rats Rats, Sprague-Dawley Receptor, Endothelin B - genetics Receptor, Endothelin B - metabolism Vascular Remodeling - drug effects
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