A Comparison of Sphenoid Sinus Osteoneogenesis in Aspirin-Exacerbated Respiratory Disease
Background Aspirin-exacerbated respiratory disease (AERD) is characterized by excessive leukotriene production, diffuse polyp burden and osteitic bone changes. These bony changes have not been previously characterized. Objective The aim of this radiographic study is to characterize the bony changes...
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| Veröffentlicht in: | American journal of rhinology & allergy 2021-03, Vol.35 (2), p.172-178, Article 1945892420941732 |
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| creator | Malfitano, Madison J. Santarelli, Griffin D. Gelpi, Mark Brown, William C. Stepp, Wesley H. Hernandez, Stephen Kimple, Adam J. Thorp, Brian D. Zanation, Adam M. Ebert, Charles S. |
| description | Background
Aspirin-exacerbated respiratory disease (AERD) is characterized by excessive leukotriene production, diffuse polyp burden and osteitic bone changes. These bony changes have not been previously characterized.
Objective
The aim of this radiographic study is to characterize the bony changes noted on computed tomography (CT) scans of the sphenoid sinus in patients with AERD compared to other diseased sinonasal inflammatory states and non-diseased controls.
Methods
A retrospective review of 43 patients with clinically confirmed AERD were included and compared to 22 non-diseased, 9 allergic fungal sinusitis, and 43 chronic rhinosinusitis controls (23 without polyps and 18 with polyps). Comparative measurements were performed using fine-cut CT scans. Sites of comparison were the intersinus septum, the left and right lateral sphenoid wall, the roof, and left and right floor of the sphenoid sinus. Standardized measurements were averaged by two separate rhinologists.
Results
Patients with AERD had an average statistically significant increase in bone thickness compared to healthy and diseased controls in nearly every site with the most pronounced changes in the intersinus septum (p |
| doi_str_mv | 10.1177/1945892420941732 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_32660262</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1945892420941732</sage_id><sourcerecordid>2423798920</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-7743018db1401db68393002c2e9a3d46d44ff96c59d50412f2d79f1c54984c1d3</originalsourceid><addsrcrecordid>eNqNkctrFTEUxoMotlb3riRLQUbzmplkI1zG-oBCwerCVcgkZ25T7k3GJKP2vzfDrRcVBLNJOPl95_Uh9JSSl5T2_SuqRCsVE4woQXvO7qHTNdRIxdn945uJE_Qo5xtCOtEK-hCdcNZ1hHXsFH3Z4CHuZ5N8jgHHCV_N1xCid_jKhyXjy1wgBohbCJB9xj7gTZ598qE5_2EspNEUcPgjrEFTYrrFb3wGk-ExejCZXYYnd_cZ-vz2_NPwvrm4fPdh2Fw0VnBRmr4XnFDpRioIdWMnueKEMMtAGe5E54SYJtXZVrmWCMom5no1UdsKJYWljp-h14e88zLuwVkIJZmdnpPfm3Sro_H6z5_gr_U2ftO9rKUlqQme3yVI8esCuei9zxZ2O1PnXrKu6-W9qmtcUXJAbYo5J5iOZSjRqyP6b0eq5Nnv7R0FvyyowIsD8B3GOGXrIVg4YoSQVkjZKbIeWmn5__Tgiyk-hiEuoVRpc5BmswV9E5cUqi__7vwnZDe0mw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2423798920</pqid></control><display><type>article</type><title>A Comparison of Sphenoid Sinus Osteoneogenesis in Aspirin-Exacerbated Respiratory Disease</title><source>Access via SAGE</source><source>MEDLINE</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>Alma/SFX Local Collection</source><creator>Malfitano, Madison J. ; Santarelli, Griffin D. ; Gelpi, Mark ; Brown, William C. ; Stepp, Wesley H. ; Hernandez, Stephen ; Kimple, Adam J. ; Thorp, Brian D. ; Zanation, Adam M. ; Ebert, Charles S.</creator><creatorcontrib>Malfitano, Madison J. ; Santarelli, Griffin D. ; Gelpi, Mark ; Brown, William C. ; Stepp, Wesley H. ; Hernandez, Stephen ; Kimple, Adam J. ; Thorp, Brian D. ; Zanation, Adam M. ; Ebert, Charles S.</creatorcontrib><description>Background
Aspirin-exacerbated respiratory disease (AERD) is characterized by excessive leukotriene production, diffuse polyp burden and osteitic bone changes. These bony changes have not been previously characterized.
Objective
The aim of this radiographic study is to characterize the bony changes noted on computed tomography (CT) scans of the sphenoid sinus in patients with AERD compared to other diseased sinonasal inflammatory states and non-diseased controls.
Methods
A retrospective review of 43 patients with clinically confirmed AERD were included and compared to 22 non-diseased, 9 allergic fungal sinusitis, and 43 chronic rhinosinusitis controls (23 without polyps and 18 with polyps). Comparative measurements were performed using fine-cut CT scans. Sites of comparison were the intersinus septum, the left and right lateral sphenoid wall, the roof, and left and right floor of the sphenoid sinus. Standardized measurements were averaged by two separate rhinologists.
Results
Patients with AERD had an average statistically significant increase in bone thickness compared to healthy and diseased controls in nearly every site with the most pronounced changes in the intersinus septum (p < 0.05).
Conclusion
Patients with AERD have significantly increased thickness of the sphenoid bone compared to control groups with the most pronounced difference in the intersinus septum. These findings may help clinicians increase suspicion for a diagnosis of AERD who clinically have diffuse nasal polyposis.</description><identifier>ISSN: 1945-8924</identifier><identifier>EISSN: 1945-8932</identifier><identifier>DOI: 10.1177/1945892420941732</identifier><identifier>PMID: 32660262</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Aspirin - adverse effects ; Asthma, Aspirin-Induced - diagnosis ; Chronic Disease ; Humans ; Life Sciences & Biomedicine ; Nasal Polyps ; Original ; Otorhinolaryngology ; Retrospective Studies ; Rhinitis - diagnosis ; Science & Technology ; Sinusitis ; Sphenoid Sinus - diagnostic imaging</subject><ispartof>American journal of rhinology & allergy, 2021-03, Vol.35 (2), p.172-178, Article 1945892420941732</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020 2020 SAGE Publications</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>5</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000548869000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c434t-7743018db1401db68393002c2e9a3d46d44ff96c59d50412f2d79f1c54984c1d3</citedby><cites>FETCH-LOGICAL-c434t-7743018db1401db68393002c2e9a3d46d44ff96c59d50412f2d79f1c54984c1d3</cites><orcidid>0000-0002-8820-1928 ; 0000-0002-5305-1210 ; 0000-0003-1670-8401</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1945892420941732$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1945892420941732$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,21824,27929,27930,39263,43626,43627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32660262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malfitano, Madison J.</creatorcontrib><creatorcontrib>Santarelli, Griffin D.</creatorcontrib><creatorcontrib>Gelpi, Mark</creatorcontrib><creatorcontrib>Brown, William C.</creatorcontrib><creatorcontrib>Stepp, Wesley H.</creatorcontrib><creatorcontrib>Hernandez, Stephen</creatorcontrib><creatorcontrib>Kimple, Adam J.</creatorcontrib><creatorcontrib>Thorp, Brian D.</creatorcontrib><creatorcontrib>Zanation, Adam M.</creatorcontrib><creatorcontrib>Ebert, Charles S.</creatorcontrib><title>A Comparison of Sphenoid Sinus Osteoneogenesis in Aspirin-Exacerbated Respiratory Disease</title><title>American journal of rhinology & allergy</title><addtitle>AM J RHINOL ALLERGY</addtitle><addtitle>Am J Rhinol Allergy</addtitle><description>Background
Aspirin-exacerbated respiratory disease (AERD) is characterized by excessive leukotriene production, diffuse polyp burden and osteitic bone changes. These bony changes have not been previously characterized.
Objective
The aim of this radiographic study is to characterize the bony changes noted on computed tomography (CT) scans of the sphenoid sinus in patients with AERD compared to other diseased sinonasal inflammatory states and non-diseased controls.
Methods
A retrospective review of 43 patients with clinically confirmed AERD were included and compared to 22 non-diseased, 9 allergic fungal sinusitis, and 43 chronic rhinosinusitis controls (23 without polyps and 18 with polyps). Comparative measurements were performed using fine-cut CT scans. Sites of comparison were the intersinus septum, the left and right lateral sphenoid wall, the roof, and left and right floor of the sphenoid sinus. Standardized measurements were averaged by two separate rhinologists.
Results
Patients with AERD had an average statistically significant increase in bone thickness compared to healthy and diseased controls in nearly every site with the most pronounced changes in the intersinus septum (p < 0.05).
Conclusion
Patients with AERD have significantly increased thickness of the sphenoid bone compared to control groups with the most pronounced difference in the intersinus septum. These findings may help clinicians increase suspicion for a diagnosis of AERD who clinically have diffuse nasal polyposis.</description><subject>Aspirin - adverse effects</subject><subject>Asthma, Aspirin-Induced - diagnosis</subject><subject>Chronic Disease</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Nasal Polyps</subject><subject>Original</subject><subject>Otorhinolaryngology</subject><subject>Retrospective Studies</subject><subject>Rhinitis - diagnosis</subject><subject>Science & Technology</subject><subject>Sinusitis</subject><subject>Sphenoid Sinus - diagnostic imaging</subject><issn>1945-8924</issn><issn>1945-8932</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkctrFTEUxoMotlb3riRLQUbzmplkI1zG-oBCwerCVcgkZ25T7k3GJKP2vzfDrRcVBLNJOPl95_Uh9JSSl5T2_SuqRCsVE4woQXvO7qHTNdRIxdn945uJE_Qo5xtCOtEK-hCdcNZ1hHXsFH3Z4CHuZ5N8jgHHCV_N1xCid_jKhyXjy1wgBohbCJB9xj7gTZ598qE5_2EspNEUcPgjrEFTYrrFb3wGk-ExejCZXYYnd_cZ-vz2_NPwvrm4fPdh2Fw0VnBRmr4XnFDpRioIdWMnueKEMMtAGe5E54SYJtXZVrmWCMom5no1UdsKJYWljp-h14e88zLuwVkIJZmdnpPfm3Sro_H6z5_gr_U2ftO9rKUlqQme3yVI8esCuei9zxZ2O1PnXrKu6-W9qmtcUXJAbYo5J5iOZSjRqyP6b0eq5Nnv7R0FvyyowIsD8B3GOGXrIVg4YoSQVkjZKbIeWmn5__Tgiyk-hiEuoVRpc5BmswV9E5cUqi__7vwnZDe0mw</recordid><startdate>20210301</startdate><enddate>20210301</enddate><creator>Malfitano, Madison J.</creator><creator>Santarelli, Griffin D.</creator><creator>Gelpi, Mark</creator><creator>Brown, William C.</creator><creator>Stepp, Wesley H.</creator><creator>Hernandez, Stephen</creator><creator>Kimple, Adam J.</creator><creator>Thorp, Brian D.</creator><creator>Zanation, Adam M.</creator><creator>Ebert, Charles S.</creator><general>SAGE Publications</general><general>Sage</general><scope>AFRWT</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8820-1928</orcidid><orcidid>https://orcid.org/0000-0002-5305-1210</orcidid><orcidid>https://orcid.org/0000-0003-1670-8401</orcidid></search><sort><creationdate>20210301</creationdate><title>A Comparison of Sphenoid Sinus Osteoneogenesis in Aspirin-Exacerbated Respiratory Disease</title><author>Malfitano, Madison J. ; Santarelli, Griffin D. ; Gelpi, Mark ; Brown, William C. ; Stepp, Wesley H. ; Hernandez, Stephen ; Kimple, Adam J. ; Thorp, Brian D. ; Zanation, Adam M. ; Ebert, Charles S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-7743018db1401db68393002c2e9a3d46d44ff96c59d50412f2d79f1c54984c1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aspirin - adverse effects</topic><topic>Asthma, Aspirin-Induced - diagnosis</topic><topic>Chronic Disease</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Nasal Polyps</topic><topic>Original</topic><topic>Otorhinolaryngology</topic><topic>Retrospective Studies</topic><topic>Rhinitis - diagnosis</topic><topic>Science & Technology</topic><topic>Sinusitis</topic><topic>Sphenoid Sinus - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malfitano, Madison J.</creatorcontrib><creatorcontrib>Santarelli, Griffin D.</creatorcontrib><creatorcontrib>Gelpi, Mark</creatorcontrib><creatorcontrib>Brown, William C.</creatorcontrib><creatorcontrib>Stepp, Wesley H.</creatorcontrib><creatorcontrib>Hernandez, Stephen</creatorcontrib><creatorcontrib>Kimple, Adam J.</creatorcontrib><creatorcontrib>Thorp, Brian D.</creatorcontrib><creatorcontrib>Zanation, Adam M.</creatorcontrib><creatorcontrib>Ebert, Charles S.</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of rhinology & allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malfitano, Madison J.</au><au>Santarelli, Griffin D.</au><au>Gelpi, Mark</au><au>Brown, William C.</au><au>Stepp, Wesley H.</au><au>Hernandez, Stephen</au><au>Kimple, Adam J.</au><au>Thorp, Brian D.</au><au>Zanation, Adam M.</au><au>Ebert, Charles S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Comparison of Sphenoid Sinus Osteoneogenesis in Aspirin-Exacerbated Respiratory Disease</atitle><jtitle>American journal of rhinology & allergy</jtitle><stitle>AM J RHINOL ALLERGY</stitle><addtitle>Am J Rhinol Allergy</addtitle><date>2021-03-01</date><risdate>2021</risdate><volume>35</volume><issue>2</issue><spage>172</spage><epage>178</epage><pages>172-178</pages><artnum>1945892420941732</artnum><issn>1945-8924</issn><eissn>1945-8932</eissn><abstract>Background
Aspirin-exacerbated respiratory disease (AERD) is characterized by excessive leukotriene production, diffuse polyp burden and osteitic bone changes. These bony changes have not been previously characterized.
Objective
The aim of this radiographic study is to characterize the bony changes noted on computed tomography (CT) scans of the sphenoid sinus in patients with AERD compared to other diseased sinonasal inflammatory states and non-diseased controls.
Methods
A retrospective review of 43 patients with clinically confirmed AERD were included and compared to 22 non-diseased, 9 allergic fungal sinusitis, and 43 chronic rhinosinusitis controls (23 without polyps and 18 with polyps). Comparative measurements were performed using fine-cut CT scans. Sites of comparison were the intersinus septum, the left and right lateral sphenoid wall, the roof, and left and right floor of the sphenoid sinus. Standardized measurements were averaged by two separate rhinologists.
Results
Patients with AERD had an average statistically significant increase in bone thickness compared to healthy and diseased controls in nearly every site with the most pronounced changes in the intersinus septum (p < 0.05).
Conclusion
Patients with AERD have significantly increased thickness of the sphenoid bone compared to control groups with the most pronounced difference in the intersinus septum. These findings may help clinicians increase suspicion for a diagnosis of AERD who clinically have diffuse nasal polyposis.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>32660262</pmid><doi>10.1177/1945892420941732</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-8820-1928</orcidid><orcidid>https://orcid.org/0000-0002-5305-1210</orcidid><orcidid>https://orcid.org/0000-0003-1670-8401</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of rhinology & allergy, 2021-03, Vol.35 (2), p.172-178, Article 1945892420941732 |
| issn | 1945-8924 1945-8932 |
| language | eng |
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| subjects | Aspirin - adverse effects Asthma, Aspirin-Induced - diagnosis Chronic Disease Humans Life Sciences & Biomedicine Nasal Polyps Original Otorhinolaryngology Retrospective Studies Rhinitis - diagnosis Science & Technology Sinusitis Sphenoid Sinus - diagnostic imaging |
| title | A Comparison of Sphenoid Sinus Osteoneogenesis in Aspirin-Exacerbated Respiratory Disease |
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