Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus

The interaction of prion protein (PrP) and α-synuclein (αSyn) oligomers causes synaptic impairment that might trigger Parkinson’s disease and other synucleinopathies. Here, we report that αSyn oligomers (αSynO) cluster with human PrP (huPrP) into micron-sized condensates. Multivalency of αSyn within...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Communications biology 2020-07, Vol.3 (1), p.365-365, Article 365
Hauptverfasser:	Rösener, Nadine S., Gremer, Lothar, Wördehoff, Michael M., Kupreichyk, Tatsiana, Etzkorn, Manuel, Neudecker, Philipp, Hoyer, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	14/3 14/33 14/63 631/45 631/535 631/57 82/29 82/6 Affinity Alzheimer's disease Amyloid Amyloidogenesis Biology Biomedical and Life Sciences Cognitive ability Condensates Life Sciences Movement disorders N-Terminus Neurodegenerative diseases Neurotoxicity Parkinson's disease Prion protein Proteins Stoichiometry Synuclein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!