Longitudinal Associations of Childhood Internalizing Psychopathology With Substance Misuse: A Register-Based Twin and Sibling Study
The pathways from internalizing psychopathology to substance misuse remain largely unclear. We estimated associations between childhood internalizing problems and subsequent substance misuse in 2 family-based samples. We also investigated sex differences and the role of externalizing comorbidity. We...
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| Veröffentlicht in: | Journal of the American Academy of Child and Adolescent Psychiatry 2021-05, Vol.60 (5), p.593-603 |
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| container_title | Journal of the American Academy of Child and Adolescent Psychiatry |
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| creator | Virtanen, Suvi Kuja-Halkola, Ralf Lundström, Sebastian D’Onofrio, Brian M. Larsson, Henrik Suvisaari, Jaana Mataix-Cols, David Lichtenstein, Paul Latvala, Antti |
| description | The pathways from internalizing psychopathology to substance misuse remain largely unclear. We estimated associations between childhood internalizing problems and subsequent substance misuse in 2 family-based samples. We also investigated sex differences and the role of externalizing comorbidity.
We studied associations of childhood internalizing psychopathology with register-based substance misuse after age 13 years. Sample 1 included all individuals born in Sweden from 1984 to 2000 (N = 1,768,516). Depressive and anxiety disorders were included as register-based International Classification of Diseases Ninth Revision (ICD-9) or Tenth Revision (ICD-10) diagnoses before age 13. Sample 2 was a subsample within the population sample, the Child and Adolescent Twin Study in Sweden (CATSS) twin cohort (n = 12,408; born 1992–1998), with mood and anxiety problems assessed at age 9/12 by parents. In both samples, substance misuse was defined as an ICD-9/10 alcohol/drug use disorder or an alcohol/drug-related criminal conviction until December 2013. To account for familial effects, stratified analyses were conducted within siblings and twin pairs.
In the population sample, both depressive (hazard ratio [HR] = 2.75, 95% CI = 2.36–3.20) and anxiety disorders (HR = 1.52, 95% CI = 1.35–1.73) were associated with substance misuse. Childhood mood problems (HR = 2.28, 95% CI = 1.69–3.08) were associated with substance misuse in the CATSS sample. The associations were partially explained by familial factors, and comorbid externalizing disorders explained the associations in men but not in women.
Childhood mood problems were associated with substance misuse, but familial factors shared by siblings partially explained the associations. The relationship of anxiety with substance misuse was complex and depended on measurement and the type of anxiety disorder. Internalizing problems may be especially important for substance misuse risk in women. |
| doi_str_mv | 10.1016/j.jaac.2020.06.009 |
| format | Article |
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We studied associations of childhood internalizing psychopathology with register-based substance misuse after age 13 years. Sample 1 included all individuals born in Sweden from 1984 to 2000 (N = 1,768,516). Depressive and anxiety disorders were included as register-based International Classification of Diseases Ninth Revision (ICD-9) or Tenth Revision (ICD-10) diagnoses before age 13. Sample 2 was a subsample within the population sample, the Child and Adolescent Twin Study in Sweden (CATSS) twin cohort (n = 12,408; born 1992–1998), with mood and anxiety problems assessed at age 9/12 by parents. In both samples, substance misuse was defined as an ICD-9/10 alcohol/drug use disorder or an alcohol/drug-related criminal conviction until December 2013. To account for familial effects, stratified analyses were conducted within siblings and twin pairs.
In the population sample, both depressive (hazard ratio [HR] = 2.75, 95% CI = 2.36–3.20) and anxiety disorders (HR = 1.52, 95% CI = 1.35–1.73) were associated with substance misuse. Childhood mood problems (HR = 2.28, 95% CI = 1.69–3.08) were associated with substance misuse in the CATSS sample. The associations were partially explained by familial factors, and comorbid externalizing disorders explained the associations in men but not in women.
Childhood mood problems were associated with substance misuse, but familial factors shared by siblings partially explained the associations. The relationship of anxiety with substance misuse was complex and depended on measurement and the type of anxiety disorder. Internalizing problems may be especially important for substance misuse risk in women.</description><identifier>ISSN: 0890-8567</identifier><identifier>ISSN: 1527-5418</identifier><identifier>EISSN: 1527-5418</identifier><identifier>DOI: 10.1016/j.jaac.2020.06.009</identifier><identifier>PMID: 32621868</identifier><language>eng</language><publisher>NEW YORK: Elsevier Inc</publisher><subject><![CDATA[Adolescents ; Age ; Alcohol use ; Anxiety ; Anxiety disorders ; Attention deficit hyperactivity disorder ; Child & adolescent psychiatry ; Childhood ; Children ; Children & youth ; Comorbidity ; Conduct disorder ; Drug abuse ; Drug use ; externalizing ; Externalizing problems ; Familial factors ; Families & family life ; Gender differences ; Internalization ; internalizing ; Internalizing disorders ; Life Sciences & Biomedicine ; longitudinal ; Longitudinal studies ; Measurement ; Medicin och hälsovetenskap ; Mental depression ; Mental disorders ; Mood ; Parents & parenting ; Pediatrics ; Pediatrik ; Psychiatry ; Psychology ; Psychology, Developmental ; Psychopathology ; Psykiatri ; Review boards ; Science & Technology ; Sex differences ; Siblings ; Social Sciences ; substance use ; Substance use disorder ; Teenagers ; Twin studies ; Twins]]></subject><ispartof>Journal of the American Academy of Child and Adolescent Psychiatry, 2021-05, Vol.60 (5), p.593-603</ispartof><rights>2020 American Academy of Child and Adolescent Psychiatry</rights><rights>Copyright © 2020 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><rights>2020. American Academy of Child and Adolescent Psychiatry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000645901200013</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c591t-5f443ef56300f94f217248b55b8c1f3e4ace20cb70b845907105c2d85b319c813</citedby><cites>FETCH-LOGICAL-c591t-5f443ef56300f94f217248b55b8c1f3e4ace20cb70b845907105c2d85b319c813</cites><orcidid>0000-0002-3765-2067 ; 0000-0002-5248-7434 ; 0000-0001-7167-0990 ; 0000-0001-5695-117X ; 0000-0002-2779-3384 ; 0000-0002-4545-0924 ; 0000-0002-6851-3297 ; 0000-0001-7235-8499 ; 0000-0003-3037-5287</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jaac.2020.06.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,553,781,785,886,3551,27929,27930,31004,39262,39263,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32621868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-84749$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/308381$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:146583409$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Virtanen, Suvi</creatorcontrib><creatorcontrib>Kuja-Halkola, Ralf</creatorcontrib><creatorcontrib>Lundström, Sebastian</creatorcontrib><creatorcontrib>D’Onofrio, Brian M.</creatorcontrib><creatorcontrib>Larsson, Henrik</creatorcontrib><creatorcontrib>Suvisaari, Jaana</creatorcontrib><creatorcontrib>Mataix-Cols, David</creatorcontrib><creatorcontrib>Lichtenstein, Paul</creatorcontrib><creatorcontrib>Latvala, Antti</creatorcontrib><title>Longitudinal Associations of Childhood Internalizing Psychopathology With Substance Misuse: A Register-Based Twin and Sibling Study</title><title>Journal of the American Academy of Child and Adolescent Psychiatry</title><addtitle>J AM ACAD CHILD PSY</addtitle><addtitle>J Am Acad Child Adolesc Psychiatry</addtitle><description>The pathways from internalizing psychopathology to substance misuse remain largely unclear. We estimated associations between childhood internalizing problems and subsequent substance misuse in 2 family-based samples. We also investigated sex differences and the role of externalizing comorbidity.
We studied associations of childhood internalizing psychopathology with register-based substance misuse after age 13 years. Sample 1 included all individuals born in Sweden from 1984 to 2000 (N = 1,768,516). Depressive and anxiety disorders were included as register-based International Classification of Diseases Ninth Revision (ICD-9) or Tenth Revision (ICD-10) diagnoses before age 13. Sample 2 was a subsample within the population sample, the Child and Adolescent Twin Study in Sweden (CATSS) twin cohort (n = 12,408; born 1992–1998), with mood and anxiety problems assessed at age 9/12 by parents. In both samples, substance misuse was defined as an ICD-9/10 alcohol/drug use disorder or an alcohol/drug-related criminal conviction until December 2013. To account for familial effects, stratified analyses were conducted within siblings and twin pairs.
In the population sample, both depressive (hazard ratio [HR] = 2.75, 95% CI = 2.36–3.20) and anxiety disorders (HR = 1.52, 95% CI = 1.35–1.73) were associated with substance misuse. Childhood mood problems (HR = 2.28, 95% CI = 1.69–3.08) were associated with substance misuse in the CATSS sample. The associations were partially explained by familial factors, and comorbid externalizing disorders explained the associations in men but not in women.
Childhood mood problems were associated with substance misuse, but familial factors shared by siblings partially explained the associations. The relationship of anxiety with substance misuse was complex and depended on measurement and the type of anxiety disorder. Internalizing problems may be especially important for substance misuse risk in women.</description><subject>Adolescents</subject><subject>Age</subject><subject>Alcohol use</subject><subject>Anxiety</subject><subject>Anxiety disorders</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Child & adolescent psychiatry</subject><subject>Childhood</subject><subject>Children</subject><subject>Children & youth</subject><subject>Comorbidity</subject><subject>Conduct disorder</subject><subject>Drug abuse</subject><subject>Drug use</subject><subject>externalizing</subject><subject>Externalizing problems</subject><subject>Familial factors</subject><subject>Families & family life</subject><subject>Gender differences</subject><subject>Internalization</subject><subject>internalizing</subject><subject>Internalizing disorders</subject><subject>Life Sciences & Biomedicine</subject><subject>longitudinal</subject><subject>Longitudinal studies</subject><subject>Measurement</subject><subject>Medicin och hälsovetenskap</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mood</subject><subject>Parents & parenting</subject><subject>Pediatrics</subject><subject>Pediatrik</subject><subject>Psychiatry</subject><subject>Psychology</subject><subject>Psychology, Developmental</subject><subject>Psychopathology</subject><subject>Psykiatri</subject><subject>Review boards</subject><subject>Science & Technology</subject><subject>Sex differences</subject><subject>Siblings</subject><subject>Social Sciences</subject><subject>substance use</subject><subject>Substance use disorder</subject><subject>Teenagers</subject><subject>Twin studies</subject><subject>Twins</subject><issn>0890-8567</issn><issn>1527-5418</issn><issn>1527-5418</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>GIZIO</sourceid><sourceid>HGBXW</sourceid><sourceid>7QJ</sourceid><sourceid>D8T</sourceid><recordid>eNqNks2O0zAUhSMEYsrAC7BAllhCyrVjOw5iU8LfSEUgOsDSchwndenEJXaoypYXx2k7ZTUjLFm2rO-ce22fJHmMYYoB8xer6UopPSVAYAp8ClDcSSaYkTxlFIu7yQREAalgPD9LHni_AgCcC3E_OcsIJ1hwMUn-zF3X2jDUtlNrNPPeaauCdZ1HrkHl0q7rpXM1uuiC6SNif9uuRZ_9Ti_dRoWlW7t2h77bsESLofJBddqgj9YP3rxEM_TFtNZHZfpaeVOjy63tkOpqtLDVejRaxMq7h8m9Rq29eXRcz5Ov795elh_S-af3F-VsnmpW4JCyhtLMNIxnAE1BG4JzQkXFWCU0bjJDlTYEdJVDJSgrIMfANKkFqzJcaIGz8yQ9-Pqt2QyV3PT2SvU76ZSVx6MfcWck5UUckS9u5De9q_-JroWYciYyCsWttdphI-NRO4ySDES27-35jfwb-20mXd_GOUhBczraPz3gsY-fg_FBrtww_o-XRFBRYJFzFilyoHTvvO9Nc7LFIMcIyZUcIyTHCEngEvadPzlaD9WVqU-S68xEQByAralc47U18c9PWAwZH18fkzFuWWnDPk6lG7oQpc_-XxrpVwfaxFD8sqaXR0Vte6ODrJ297SJ_AQ3E-1Q</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Virtanen, Suvi</creator><creator>Kuja-Halkola, Ralf</creator><creator>Lundström, Sebastian</creator><creator>D’Onofrio, Brian M.</creator><creator>Larsson, Henrik</creator><creator>Suvisaari, Jaana</creator><creator>Mataix-Cols, David</creator><creator>Lichtenstein, Paul</creator><creator>Latvala, Antti</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier BV</general><scope>17B</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>GIZIO</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>K9.</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D91</scope><scope>F1U</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-3765-2067</orcidid><orcidid>https://orcid.org/0000-0002-5248-7434</orcidid><orcidid>https://orcid.org/0000-0001-7167-0990</orcidid><orcidid>https://orcid.org/0000-0001-5695-117X</orcidid><orcidid>https://orcid.org/0000-0002-2779-3384</orcidid><orcidid>https://orcid.org/0000-0002-4545-0924</orcidid><orcidid>https://orcid.org/0000-0002-6851-3297</orcidid><orcidid>https://orcid.org/0000-0001-7235-8499</orcidid><orcidid>https://orcid.org/0000-0003-3037-5287</orcidid></search><sort><creationdate>20210501</creationdate><title>Longitudinal Associations of Childhood Internalizing Psychopathology With Substance Misuse: A Register-Based Twin and Sibling Study</title><author>Virtanen, Suvi ; Kuja-Halkola, Ralf ; Lundström, Sebastian ; D’Onofrio, Brian M. ; Larsson, Henrik ; Suvisaari, Jaana ; Mataix-Cols, David ; Lichtenstein, Paul ; Latvala, Antti</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-5f443ef56300f94f217248b55b8c1f3e4ace20cb70b845907105c2d85b319c813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescents</topic><topic>Age</topic><topic>Alcohol use</topic><topic>Anxiety</topic><topic>Anxiety disorders</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Child & adolescent psychiatry</topic><topic>Childhood</topic><topic>Children</topic><topic>Children & youth</topic><topic>Comorbidity</topic><topic>Conduct disorder</topic><topic>Drug abuse</topic><topic>Drug use</topic><topic>externalizing</topic><topic>Externalizing problems</topic><topic>Familial factors</topic><topic>Families & family life</topic><topic>Gender differences</topic><topic>Internalization</topic><topic>internalizing</topic><topic>Internalizing disorders</topic><topic>Life Sciences & Biomedicine</topic><topic>longitudinal</topic><topic>Longitudinal studies</topic><topic>Measurement</topic><topic>Medicin och hälsovetenskap</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Mood</topic><topic>Parents & parenting</topic><topic>Pediatrics</topic><topic>Pediatrik</topic><topic>Psychiatry</topic><topic>Psychology</topic><topic>Psychology, Developmental</topic><topic>Psychopathology</topic><topic>Psykiatri</topic><topic>Review boards</topic><topic>Science & Technology</topic><topic>Sex differences</topic><topic>Siblings</topic><topic>Social Sciences</topic><topic>substance use</topic><topic>Substance use disorder</topic><topic>Teenagers</topic><topic>Twin studies</topic><topic>Twins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Virtanen, Suvi</creatorcontrib><creatorcontrib>Kuja-Halkola, Ralf</creatorcontrib><creatorcontrib>Lundström, Sebastian</creatorcontrib><creatorcontrib>D’Onofrio, Brian M.</creatorcontrib><creatorcontrib>Larsson, Henrik</creatorcontrib><creatorcontrib>Suvisaari, Jaana</creatorcontrib><creatorcontrib>Mataix-Cols, David</creatorcontrib><creatorcontrib>Lichtenstein, Paul</creatorcontrib><creatorcontrib>Latvala, Antti</creatorcontrib><collection>Web of Knowledge</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI & AHCI)</collection><collection>Web of Science - Social Sciences Citation Index – 2021</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Örebro universitet</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Virtanen, Suvi</au><au>Kuja-Halkola, Ralf</au><au>Lundström, Sebastian</au><au>D’Onofrio, Brian M.</au><au>Larsson, Henrik</au><au>Suvisaari, Jaana</au><au>Mataix-Cols, David</au><au>Lichtenstein, Paul</au><au>Latvala, Antti</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal Associations of Childhood Internalizing Psychopathology With Substance Misuse: A Register-Based Twin and Sibling Study</atitle><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle><stitle>J AM ACAD CHILD PSY</stitle><addtitle>J Am Acad Child Adolesc Psychiatry</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>60</volume><issue>5</issue><spage>593</spage><epage>603</epage><pages>593-603</pages><issn>0890-8567</issn><issn>1527-5418</issn><eissn>1527-5418</eissn><abstract>The pathways from internalizing psychopathology to substance misuse remain largely unclear. We estimated associations between childhood internalizing problems and subsequent substance misuse in 2 family-based samples. We also investigated sex differences and the role of externalizing comorbidity.
We studied associations of childhood internalizing psychopathology with register-based substance misuse after age 13 years. Sample 1 included all individuals born in Sweden from 1984 to 2000 (N = 1,768,516). Depressive and anxiety disorders were included as register-based International Classification of Diseases Ninth Revision (ICD-9) or Tenth Revision (ICD-10) diagnoses before age 13. Sample 2 was a subsample within the population sample, the Child and Adolescent Twin Study in Sweden (CATSS) twin cohort (n = 12,408; born 1992–1998), with mood and anxiety problems assessed at age 9/12 by parents. In both samples, substance misuse was defined as an ICD-9/10 alcohol/drug use disorder or an alcohol/drug-related criminal conviction until December 2013. To account for familial effects, stratified analyses were conducted within siblings and twin pairs.
In the population sample, both depressive (hazard ratio [HR] = 2.75, 95% CI = 2.36–3.20) and anxiety disorders (HR = 1.52, 95% CI = 1.35–1.73) were associated with substance misuse. Childhood mood problems (HR = 2.28, 95% CI = 1.69–3.08) were associated with substance misuse in the CATSS sample. The associations were partially explained by familial factors, and comorbid externalizing disorders explained the associations in men but not in women.
Childhood mood problems were associated with substance misuse, but familial factors shared by siblings partially explained the associations. The relationship of anxiety with substance misuse was complex and depended on measurement and the type of anxiety disorder. Internalizing problems may be especially important for substance misuse risk in women.</abstract><cop>NEW YORK</cop><pub>Elsevier Inc</pub><pmid>32621868</pmid><doi>10.1016/j.jaac.2020.06.009</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-3765-2067</orcidid><orcidid>https://orcid.org/0000-0002-5248-7434</orcidid><orcidid>https://orcid.org/0000-0001-7167-0990</orcidid><orcidid>https://orcid.org/0000-0001-5695-117X</orcidid><orcidid>https://orcid.org/0000-0002-2779-3384</orcidid><orcidid>https://orcid.org/0000-0002-4545-0924</orcidid><orcidid>https://orcid.org/0000-0002-6851-3297</orcidid><orcidid>https://orcid.org/0000-0001-7235-8499</orcidid><orcidid>https://orcid.org/0000-0003-3037-5287</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the American Academy of Child and Adolescent Psychiatry, 2021-05, Vol.60 (5), p.593-603 |
| issn | 0890-8567 1527-5418 1527-5418 |
| language | eng |
| recordid | cdi_pubmed_primary_32621868 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); Elsevier ScienceDirect Journals Complete; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Web of Science - Social Sciences Citation Index – 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; SWEPUB Freely available online |
| subjects | Adolescents Age Alcohol use Anxiety Anxiety disorders Attention deficit hyperactivity disorder Child & adolescent psychiatry Childhood Children Children & youth Comorbidity Conduct disorder Drug abuse Drug use externalizing Externalizing problems Familial factors Families & family life Gender differences Internalization internalizing Internalizing disorders Life Sciences & Biomedicine longitudinal Longitudinal studies Measurement Medicin och hälsovetenskap Mental depression Mental disorders Mood Parents & parenting Pediatrics Pediatrik Psychiatry Psychology Psychology, Developmental Psychopathology Psykiatri Review boards Science & Technology Sex differences Siblings Social Sciences substance use Substance use disorder Teenagers Twin studies Twins |
| title | Longitudinal Associations of Childhood Internalizing Psychopathology With Substance Misuse: A Register-Based Twin and Sibling Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T18%3A50%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Longitudinal%20Associations%20of%20Childhood%20Internalizing%20Psychopathology%20With%20Substance%20Misuse:%20A%20Register-Based%20Twin%20and%20Sibling%20Study&rft.jtitle=Journal%20of%20the%20American%20Academy%20of%20Child%20and%20Adolescent%20Psychiatry&rft.au=Virtanen,%20Suvi&rft.date=2021-05-01&rft.volume=60&rft.issue=5&rft.spage=593&rft.epage=603&rft.pages=593-603&rft.issn=0890-8567&rft.eissn=1527-5418&rft_id=info:doi/10.1016/j.jaac.2020.06.009&rft_dat=%3Cproquest_pubme%3E2848918765%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2848918765&rft_id=info:pmid/32621868&rft_els_id=S0890856720303877&rfr_iscdi=true |