Protein dynamics of [Cu-Zn] superoxide dismutase (SOD1): How protein motions at the global and local levels impact the reactivity of SOD1

This work explores the pivotal role that protein mobility plays in facilitating the catalytic activity of Copper-Zinc superoxide dismutase (SOD1). Through both localized active site distortions and correlated domain movement, these motions enable the enzyme to adopt the conformations necessary to ac...

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Veröffentlicht in:	Journal of inorganic biochemistry 2020-09, Vol.210, p.111161-111161, Article 111161
Hauptverfasser:	Healy, Eamonn F., Flores, Rafael, Lynch, Vincent M., Toledo, Santiago
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomimetic model Normal mode analysis Protein motion SOD1 Superoxide dusmutase
Online-Zugang:	Volltext
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