Amphiphilic dendrimers control protein binding and corona formation on liposome nanocarriers
Amphiphilic polyphenylene dendrimers (PPDs) with distinct lipophilic and positively or negatively charged surface groups were adsorbed onto liposomes and their impact on protein adsorption in blood plasma was studied. The PPD corona reduced binding of specific opsonins and increased the adsorption o...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2020-08, Vol.56 (61), p.8663-8666 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Wagner, Jessica Dillenburger, Marcel Simon, Johanna Oberländer, Jennifer Landfester, Katharina Mailänder, Volker Ng, David Y. W Müllen, Klaus Weil, Tanja |
| description | Amphiphilic polyphenylene dendrimers (PPDs) with distinct lipophilic and positively or negatively charged surface groups were adsorbed onto liposomes and their impact on protein adsorption in blood plasma was studied. The PPD corona reduced binding of specific opsonins and increased the adsorption of proteins controlling cellular uptake based on their surface patches.
Amphiphilic polyphenylene dendrimers adsorbed to liposomes alter the protein corona dependent on their charge and hydrophobicity. |
| doi_str_mv | 10.1039/d0cc02486d |
| format | Article |
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Amphiphilic polyphenylene dendrimers adsorbed to liposomes alter the protein corona dependent on their charge and hydrophobicity.</description><subject>Adsorption</subject><subject>Binding</subject><subject>Blood plasma</subject><subject>Blood Proteins - chemistry</subject><subject>Blood Proteins - metabolism</subject><subject>Catalysis</subject><subject>Dendrimers</subject><subject>Dendrimers - chemical synthesis</subject><subject>Dendrimers - chemistry</subject><subject>Humans</subject><subject>Liposomes</subject><subject>Liposomes - chemistry</subject><subject>Nanoparticles - chemistry</subject><subject>Palladium - chemistry</subject><subject>Polymers - chemistry</subject><subject>Protein adsorption</subject><subject>Protein Binding</subject><subject>Protein Corona - chemistry</subject><subject>Proteins</subject><subject>Surface chemistry</subject><subject>Surface Properties</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtLAzEUhYMotlY37pWIO2E0mcxkkmWZ-oKCGwUXwpDJQ1M6yZhMF_57U1vrznAhgftx7j0nAJxidI0R4TcKSYnyglG1B8aY0CIrC_a6v36XPKtIUY7AUYwLlA4u2SEYkZwiRjgbg7dp13_YVEsrodJOBdvpEKH0bgh-CfvgB20dbK1T1r1D4VTqBe8END50YrDewVRL2_voOw2dcF6KEGxSOQYHRiyjPtneE_Byd_tcP2Tzp_vHejrPJOF8yJSqGOWiag2pMDMMV3kpjEyuqDAVLymVLRKKsBYzykipcqGVzNvKJM8MF2QCLje6advPlY5Ds_Cr4NLIJi9yxhnmiCbqakPJ4GMM2jR9MivCV4NRsw6ymaG6_glyluDzreSq7bTaob_JJeBiA4Qod92_n2h6ZRJz9h9DvgGhVISc</recordid><startdate>20200807</startdate><enddate>20200807</enddate><creator>Wagner, Jessica</creator><creator>Dillenburger, Marcel</creator><creator>Simon, Johanna</creator><creator>Oberländer, Jennifer</creator><creator>Landfester, Katharina</creator><creator>Mailänder, Volker</creator><creator>Ng, David Y. 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| ispartof | Chemical communications (Cambridge, England), 2020-08, Vol.56 (61), p.8663-8666 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Adsorption Binding Blood plasma Blood Proteins - chemistry Blood Proteins - metabolism Catalysis Dendrimers Dendrimers - chemical synthesis Dendrimers - chemistry Humans Liposomes Liposomes - chemistry Nanoparticles - chemistry Palladium - chemistry Polymers - chemistry Protein adsorption Protein Binding Protein Corona - chemistry Proteins Surface chemistry Surface Properties |
| title | Amphiphilic dendrimers control protein binding and corona formation on liposome nanocarriers |
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