Sophocarpine exert protective effect against ox-LDL-induced endothelial damage via regulating NF-κB signaling pathway

Oxidized low-density lipoprotein (ox-LDL) was known to induce endothelial cell injury to the progression of atherosclerosis (AS). Sophocarpine (SPC), a compound of sophora alkaloids isolated from the plant Sophora alopecuroides, has been shown to exhibit various pharmacological activities. This stud...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2020-10, Vol.84 (10), p.2104-2112
Hauptverfasser:	Fang, Hengrong, Bo, Taizhu, Zi, Xiaolong, Tan, Dianxiang, Liu, Xiaoping, Jiang, Chonghui, Lei, Gang, Deng, Yufen, Cui, Libao
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology apoptosis Apoptosis - drug effects Cell Line Cytoprotection - drug effects Down-Regulation - drug effects Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism endothelial damage Humans Lipoproteins, LDL - pharmacology NF-kappa B - metabolism NF-κB ox-LDL Signal Transduction - drug effects Sophocarpine
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