Histone chaperone FACT FAcilitates Chromatin Transcription: mechanistic and structural insights

Histone chaperone FACT FAcilitates Chromatin Transcription: mechanistic and structural insights

The histone chaperone FACT (FAcilitates Chromatin Transcription) modulates nucleosome structure during many processes requiring access to chromatinized DNA. Here, we review recent biochemical and structural insight into how FACT acts in both nucleosome assembly and disassembly, to maintain chromatin...

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Veröffentlicht in:Current opinion in structural biology 2020-12, Vol.65, p.26-32
Hauptverfasser: Zhou, Keda, Liu, Yang, Luger, Karolin
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry & Molecular Biology
Cell Biology
Life Sciences & Biomedicine
Science & Technology
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Zusammenfassung:The histone chaperone FACT (FAcilitates Chromatin Transcription) modulates nucleosome structure during many processes requiring access to chromatinized DNA. Here, we review recent biochemical and structural insight into how FACT acts in both nucleosome assembly and disassembly, to maintain chromatin structure while DNA is being worked on by polymerases.
ISSN:0959-440X
1879-033X
DOI:10.1016/j.sbi.2020.05.019