Improved clinical symptoms and mortality among patients with severe or critical COVID-19 after convalescent plasma transfusion

Two case series examining the impact of convalescent plasma on patients with COVID-19 suggest some clinical benefit from early administration and modest impact on parameters of inflammation. Further assessment of the impact of this intervention awaits controlled clinical trials.

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Veröffentlicht in:	Blood 2020-08, Vol.136 (6), p.755-759
Hauptverfasser:	Xia, Xinyi, Li, Kening, Wu, Lingxiang, Wang, Zhihua, Zhu, Mengyan, Huang, Bin, Li, Jie, Wang, Ziyu, Wu, Wei, Wu, Min, Li, Wanlin, Li, Lu, Cai, Yun, Bosco, Bakwatanisa, Zhong, Aifang, Liu, Xiong, Lv, Tangfeng, Gan, Zhenhua, Chen, Guang, Pan, Yunhu, Liu, Caidong, Zhang, Kai, Xu, Xiaoli, Wang, Changjun, Wang, Qianghu
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Betacoronavirus - isolation & purification Betacoronavirus - physiology Blood Component Transfusion - methods China - epidemiology Coronavirus Infections - diagnosis Coronavirus Infections - epidemiology Coronavirus Infections - therapy COVID-19 Female Hematology Humans Immunization, Passive - methods Letter to Blood Life Sciences & Biomedicine Male Middle Aged Pandemics Pneumonia, Viral - diagnosis Pneumonia, Viral - epidemiology Pneumonia, Viral - therapy SARS-CoV-2 Science & Technology Treatment Outcome Viral Load
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Beschreibung
Zusammenfassung:	Two case series examining the impact of convalescent plasma on patients with COVID-19 suggest some clinical benefit from early administration and modest impact on parameters of inflammation. Further assessment of the impact of this intervention awaits controlled clinical trials.
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood.2020007079