Hg-C bond protonolysis by a functional model of bacterial enzyme organomercurial lyase MerB

Herein, we report a novel synthetic compound 1 , having a highly nucleophilic selenolate (Se − ) moiety and a thiol (-SH) functional group, which showed efficient Hg-C bond protonolysis of various R-Hg-X molecules including neurotoxic methylmercury and thimerosal, via direct -SH proton transfer to t...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2020-08, Vol.56 (65), p.928-9283
Hauptverfasser:	Karri, Ramesh, Das, Ranajit, Rai, Rakesh Kumar, Gopalakrishnan, Anaswara, Roy, Gouriprasanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - metabolism Carbon - chemistry Crystallography Functional groups Lyases - chemistry Lyases - metabolism Mercury (metal) Mercury - chemistry Models, Molecular NMR Nuclear magnetic resonance Protons Room temperature Selenium Selenium Compounds - chemistry Sulfhydryl Compounds - chemistry Temperature
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