Activated α 2 -macroglobulin binding to cell surface GRP78 induces trophoblastic cell fusion

The villous cytotrophoblastic cells have the ability to fuse and differentiate, forming the syncytiotrophoblast (STB). The syncytialisation process is essential for placentation. Nevertheless, the mechanisms involved in cell fusion and differentiation are yet to be fully elucidated. It has been sugg...

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Veröffentlicht in:	Scientific reports 2020-06, Vol.10 (1), p.9666
Hauptverfasser:	Bastida-Ruiz, Daniel, Wuillemin, Christine, Pederencino, Aude, Yaron, Michal, Martinez de Tejada, Begoña, Pizzo, Salvatore Vincent, Cohen, Marie
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Macroglobulins - genetics alpha-Macroglobulins - metabolism Cell Fusion Cell Line Choriocarcinoma - genetics Choriocarcinoma - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Down-Regulation Female Heat-Shock Proteins - metabolism Humans MAP Kinase Signaling System Phosphorylation Pregnancy Signal Transduction Trophoblasts - cytology Trophoblasts - metabolism Unfolded Protein Response Uterine Neoplasms - genetics Uterine Neoplasms - metabolism
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