The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease

Insulin resistance and hepatic lipid accumulation constitute the metabolic underpinning of nonalcoholic steatohepatitis (NASH). We tested the hypothesis that saroglitazar, a PPAR α/γ agonist would improve NASH in the diet-induced animal model of NAFLD. Mice received chow diet and normal water (CDNW)...

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Veröffentlicht in:	Scientific reports 2020-06, Vol.10 (1), p.9330-9330, Article 9330
Hauptverfasser:	Kumar, Divya P., Caffrey, Rebecca, Marioneaux, Jonathon, Santhekadur, Prasanna K., Bhat, Madhavi, Alonso, Cristina, Koduru, Srinivas V., Philip, Binu, Jain, Mukul R., Giri, Suresh R., Bedossa, Pierre, Sanyal, Arun J.
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308 692/4020 692/700 Agonists Animal models Animals Cholesterol Diet Diet, High-Fat - adverse effects Disease Models, Animal Disease resistance Dyslipidemias - complications Endoplasmic Reticulum Stress - drug effects Fatty liver Fibrosis Gene Expression Profiling High fat diet Humanities and Social Sciences Inflammation Insulin Insulin Resistance Liver - drug effects Liver - metabolism Liver - pathology Liver Cirrhosis - complications Liver diseases Metabolomics multidisciplinary Multidisciplinary Sciences Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Oxidative stress Peroxisome proliferator-activated receptors Phenylpropionates - pharmacology Phenylpropionates - therapeutic use Pioglitazone PPAR alpha - agonists PPAR gamma - agonists Protein folding Pyrroles - pharmacology Pyrroles - therapeutic use Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Signal Transduction - drug effects Steatosis Triglycerides
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