Retinal Nerve Fiber Layer Thickness and Oxidative Stress Parameters in Migraine Patients without Aura: A Pilot Study
Background: Migraine is one of the most common disorders and its pathophysiological mechanisms are still under research, oxidative stress being emphasized as an important contributor. This study aimed to analyze the retinal nerve fiber layer (RNFL) thickness and oxidative/anti-oxidant balance in mig...
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| Veröffentlicht in: | Antioxidants 2020-06, Vol.9 (6), p.494, Article 494 |
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| description | Background: Migraine is one of the most common disorders and its pathophysiological mechanisms are still under research, oxidative stress being emphasized as an important contributor. This study aimed to analyze the retinal nerve fiber layer (RNFL) thickness and oxidative/anti-oxidant balance in migraine patients. Methods: Two groups of subjects were evaluated: a group of patients with migraine and a control group of healthy volunteers. RNFL thickness was assessed for all subjects by the ocular coherence tomography spectral domain (OCT-SD). The oxidative stress parameter, namely nitric oxide (NOx), malondialdehyde (MDA), and total oxidative stress (TOS) were assessed. The antioxidant capacity of plasma was evaluated by assessing the level of catalase, and total anti-oxidative (TOS) capacity. Migraine severity was graded using the Migraine Disability Assessment Score (MIDAS) questionnaire. Results: All the oxidative stress parameters (NOx, MDA, and TOS) were significantly increased, and both parameters for anti-oxidative status were significantly decreased in the migraine group compared with the control group (p< 0.0001). Significant correlations with all the quadrants and different oxidative stress parameters were found, most involved being temporal quadrant. A significant positive correlation between catalase and macular RNFL thickness (inner ring, temporal quadrant) in migraine patients, for both eyes, was observed (p= 0.014 for the right eye andp= 0.12 for the left eye). Conclusion: The assessment of the oxidative stress/anti-oxidative balance together with RFLN thickness can constitute a promising method to evaluate the progression of the diseases. It can also contribute to the estimation of the efficiency of various therapies targeting oxidative stress and associated inflammation. |
| doi_str_mv | 10.3390/antiox9060494 |
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This study aimed to analyze the retinal nerve fiber layer (RNFL) thickness and oxidative/anti-oxidant balance in migraine patients. Methods: Two groups of subjects were evaluated: a group of patients with migraine and a control group of healthy volunteers. RNFL thickness was assessed for all subjects by the ocular coherence tomography spectral domain (OCT-SD). The oxidative stress parameter, namely nitric oxide (NOx), malondialdehyde (MDA), and total oxidative stress (TOS) were assessed. The antioxidant capacity of plasma was evaluated by assessing the level of catalase, and total anti-oxidative (TOS) capacity. Migraine severity was graded using the Migraine Disability Assessment Score (MIDAS) questionnaire. Results: All the oxidative stress parameters (NOx, MDA, and TOS) were significantly increased, and both parameters for anti-oxidative status were significantly decreased in the migraine group compared with the control group (p< 0.0001). Significant correlations with all the quadrants and different oxidative stress parameters were found, most involved being temporal quadrant. A significant positive correlation between catalase and macular RNFL thickness (inner ring, temporal quadrant) in migraine patients, for both eyes, was observed (p= 0.014 for the right eye andp= 0.12 for the left eye). Conclusion: The assessment of the oxidative stress/anti-oxidative balance together with RFLN thickness can constitute a promising method to evaluate the progression of the diseases. It can also contribute to the estimation of the efficiency of various therapies targeting oxidative stress and associated inflammation.</description><identifier>ISSN: 2076-3921</identifier><identifier>EISSN: 2076-3921</identifier><identifier>DOI: 10.3390/antiox9060494</identifier><identifier>PMID: 32516927</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Antioxidants ; Biochemistry & Molecular Biology ; Catalase ; Chemistry, Medicinal ; Diabetic retinopathy ; Disease ; Eye ; Food Science & Technology ; Headache ; Headaches ; Health aspects ; Hospitals ; Life Sciences & Biomedicine ; Malondialdehyde ; Migraine ; Nitric oxide ; Optic nerve ; optical coherence tomography (OCT) ; Optics ; Oxidants ; Oxidative stress ; Pathogenesis ; Pharmacology & Pharmacy ; Physiological aspects ; Rehabilitation ; Retina ; retinal nerve fiber layer (RNFL) thickness ; Science & Technology ; Tomography</subject><ispartof>Antioxidants, 2020-06, Vol.9 (6), p.494, Article 494</ispartof><rights>COPYRIGHT 2020 MDPI AG</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>11</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000551532200001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c509t-12d1db152f3fc97a0d5c04a879a58f1bd1bd7c04fc67e7083307c9eca7e6eaa93</citedby><cites>FETCH-LOGICAL-c509t-12d1db152f3fc97a0d5c04a879a58f1bd1bd7c04fc67e7083307c9eca7e6eaa93</cites><orcidid>0000-0001-7748-382X ; 0000-0002-2342-4311 ; 0000-0003-0613-9575 ; 0000-0002-3222-6448</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346136/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346136/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2118,27933,27934,28257,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32516927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bulboaca, Adriana Elena</creatorcontrib><creatorcontrib>Stanescu, Ioana C.</creatorcontrib><creatorcontrib>Bolboaca, Sorana D.</creatorcontrib><creatorcontrib>Bulboaca, Angelo C.</creatorcontrib><creatorcontrib>Bodizs, Gyorgy</creatorcontrib><creatorcontrib>Nicula, Cristina A.</creatorcontrib><title>Retinal Nerve Fiber Layer Thickness and Oxidative Stress Parameters in Migraine Patients without Aura: A Pilot Study</title><title>Antioxidants</title><addtitle>ANTIOXIDANTS-BASEL</addtitle><addtitle>Antioxidants (Basel)</addtitle><description>Background: Migraine is one of the most common disorders and its pathophysiological mechanisms are still under research, oxidative stress being emphasized as an important contributor. This study aimed to analyze the retinal nerve fiber layer (RNFL) thickness and oxidative/anti-oxidant balance in migraine patients. Methods: Two groups of subjects were evaluated: a group of patients with migraine and a control group of healthy volunteers. RNFL thickness was assessed for all subjects by the ocular coherence tomography spectral domain (OCT-SD). The oxidative stress parameter, namely nitric oxide (NOx), malondialdehyde (MDA), and total oxidative stress (TOS) were assessed. The antioxidant capacity of plasma was evaluated by assessing the level of catalase, and total anti-oxidative (TOS) capacity. Migraine severity was graded using the Migraine Disability Assessment Score (MIDAS) questionnaire. Results: All the oxidative stress parameters (NOx, MDA, and TOS) were significantly increased, and both parameters for anti-oxidative status were significantly decreased in the migraine group compared with the control group (p< 0.0001). Significant correlations with all the quadrants and different oxidative stress parameters were found, most involved being temporal quadrant. A significant positive correlation between catalase and macular RNFL thickness (inner ring, temporal quadrant) in migraine patients, for both eyes, was observed (p= 0.014 for the right eye andp= 0.12 for the left eye). Conclusion: The assessment of the oxidative stress/anti-oxidative balance together with RFLN thickness can constitute a promising method to evaluate the progression of the diseases. It can also contribute to the estimation of the efficiency of various therapies targeting oxidative stress and associated inflammation.</description><subject>Antioxidants</subject><subject>Biochemistry & Molecular Biology</subject><subject>Catalase</subject><subject>Chemistry, Medicinal</subject><subject>Diabetic retinopathy</subject><subject>Disease</subject><subject>Eye</subject><subject>Food Science & Technology</subject><subject>Headache</subject><subject>Headaches</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Life Sciences & Biomedicine</subject><subject>Malondialdehyde</subject><subject>Migraine</subject><subject>Nitric oxide</subject><subject>Optic nerve</subject><subject>optical coherence tomography (OCT)</subject><subject>Optics</subject><subject>Oxidants</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Pharmacology & Pharmacy</subject><subject>Physiological aspects</subject><subject>Rehabilitation</subject><subject>Retina</subject><subject>retinal nerve fiber layer (RNFL) thickness</subject><subject>Science & Technology</subject><subject>Tomography</subject><issn>2076-3921</issn><issn>2076-3921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkt1vFCEUxSdGY5vaR1_NJL6YmFU-hpnBB5PNxmqT1TZan8kd5rJLnYUWmLb738t269r1SUKAHH4cuOEUxUtK3nEuyXtwyfo7SWpSyepJcchIU0-4ZPTpo_VBcRzjJclNUt4S-bw44EzQWrLmsEjfMVkHQ_kNww2WJ7bDUM5hnceLpdW_HMZYguvLszvbQ7KZ-ZHCRjyHACtMGGJpXfnVLgJYh1lOFl2K5a1NSz-mcjoG-FBOy3M7-JQPj_36RfHMwBDx-GE-Kn6efLqYfZnMzz6fzqbziRZEpgllPe07KpjhRssGSC80qaBtJIjW0K7PvcmK0XWDDWk5J42WqKHBGgEkPypOt769h0t1FewKwlp5sOpe8GGhICSrB1RgWmMI9G3XVRXrGABmgRPJhIGubrPXx63X1ditsNe5xgDDnun-jrNLtfA3quFVTXmdDd48GAR_PWJMamWjxmEAh36MilWUCsEbRjP6-h_00o8h_9I9RSThQtR_qQXkAqwzPt-rN6ZqWldMsraqNu-ebCkdfIwBze7JlKhNiNReiDL_6nGdO_pPZDLwdgvcYudN1Pm3Ne6wnDIhqOCMbQK3KaX9f3pmU06PdzM_usR_A0EE5OY</recordid><startdate>20200605</startdate><enddate>20200605</enddate><creator>Bulboaca, Adriana Elena</creator><creator>Stanescu, Ioana C.</creator><creator>Bolboaca, Sorana D.</creator><creator>Bulboaca, Angelo C.</creator><creator>Bodizs, Gyorgy</creator><creator>Nicula, Cristina A.</creator><general>Mdpi</general><general>MDPI AG</general><general>MDPI</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7T5</scope><scope>7TO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7748-382X</orcidid><orcidid>https://orcid.org/0000-0002-2342-4311</orcidid><orcidid>https://orcid.org/0000-0003-0613-9575</orcidid><orcidid>https://orcid.org/0000-0002-3222-6448</orcidid></search><sort><creationdate>20200605</creationdate><title>Retinal Nerve Fiber Layer Thickness and Oxidative Stress Parameters in Migraine Patients without Aura: A Pilot Study</title><author>Bulboaca, Adriana Elena ; Stanescu, Ioana C. ; Bolboaca, Sorana D. ; Bulboaca, Angelo C. ; Bodizs, Gyorgy ; Nicula, Cristina A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-12d1db152f3fc97a0d5c04a879a58f1bd1bd7c04fc67e7083307c9eca7e6eaa93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antioxidants</topic><topic>Biochemistry & Molecular Biology</topic><topic>Catalase</topic><topic>Chemistry, Medicinal</topic><topic>Diabetic retinopathy</topic><topic>Disease</topic><topic>Eye</topic><topic>Food Science & Technology</topic><topic>Headache</topic><topic>Headaches</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>Life Sciences & Biomedicine</topic><topic>Malondialdehyde</topic><topic>Migraine</topic><topic>Nitric oxide</topic><topic>Optic nerve</topic><topic>optical coherence tomography (OCT)</topic><topic>Optics</topic><topic>Oxidants</topic><topic>Oxidative stress</topic><topic>Pathogenesis</topic><topic>Pharmacology & Pharmacy</topic><topic>Physiological aspects</topic><topic>Rehabilitation</topic><topic>Retina</topic><topic>retinal nerve fiber layer (RNFL) thickness</topic><topic>Science & Technology</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bulboaca, Adriana Elena</creatorcontrib><creatorcontrib>Stanescu, Ioana C.</creatorcontrib><creatorcontrib>Bolboaca, Sorana D.</creatorcontrib><creatorcontrib>Bulboaca, Angelo C.</creatorcontrib><creatorcontrib>Bodizs, Gyorgy</creatorcontrib><creatorcontrib>Nicula, Cristina A.</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Antioxidants</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bulboaca, Adriana Elena</au><au>Stanescu, Ioana C.</au><au>Bolboaca, Sorana D.</au><au>Bulboaca, Angelo C.</au><au>Bodizs, Gyorgy</au><au>Nicula, Cristina A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal Nerve Fiber Layer Thickness and Oxidative Stress Parameters in Migraine Patients without Aura: A Pilot Study</atitle><jtitle>Antioxidants</jtitle><stitle>ANTIOXIDANTS-BASEL</stitle><addtitle>Antioxidants (Basel)</addtitle><date>2020-06-05</date><risdate>2020</risdate><volume>9</volume><issue>6</issue><spage>494</spage><pages>494-</pages><artnum>494</artnum><issn>2076-3921</issn><eissn>2076-3921</eissn><abstract>Background: Migraine is one of the most common disorders and its pathophysiological mechanisms are still under research, oxidative stress being emphasized as an important contributor. This study aimed to analyze the retinal nerve fiber layer (RNFL) thickness and oxidative/anti-oxidant balance in migraine patients. Methods: Two groups of subjects were evaluated: a group of patients with migraine and a control group of healthy volunteers. RNFL thickness was assessed for all subjects by the ocular coherence tomography spectral domain (OCT-SD). The oxidative stress parameter, namely nitric oxide (NOx), malondialdehyde (MDA), and total oxidative stress (TOS) were assessed. The antioxidant capacity of plasma was evaluated by assessing the level of catalase, and total anti-oxidative (TOS) capacity. Migraine severity was graded using the Migraine Disability Assessment Score (MIDAS) questionnaire. Results: All the oxidative stress parameters (NOx, MDA, and TOS) were significantly increased, and both parameters for anti-oxidative status were significantly decreased in the migraine group compared with the control group (p< 0.0001). Significant correlations with all the quadrants and different oxidative stress parameters were found, most involved being temporal quadrant. A significant positive correlation between catalase and macular RNFL thickness (inner ring, temporal quadrant) in migraine patients, for both eyes, was observed (p= 0.014 for the right eye andp= 0.12 for the left eye). Conclusion: The assessment of the oxidative stress/anti-oxidative balance together with RFLN thickness can constitute a promising method to evaluate the progression of the diseases. It can also contribute to the estimation of the efficiency of various therapies targeting oxidative stress and associated inflammation.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>32516927</pmid><doi>10.3390/antiox9060494</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-7748-382X</orcidid><orcidid>https://orcid.org/0000-0002-2342-4311</orcidid><orcidid>https://orcid.org/0000-0003-0613-9575</orcidid><orcidid>https://orcid.org/0000-0002-3222-6448</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Biochemistry & Molecular Biology Catalase Chemistry, Medicinal Diabetic retinopathy Disease Eye Food Science & Technology Headache Headaches Health aspects Hospitals Life Sciences & Biomedicine Malondialdehyde Migraine Nitric oxide Optic nerve optical coherence tomography (OCT) Optics Oxidants Oxidative stress Pathogenesis Pharmacology & Pharmacy Physiological aspects Rehabilitation Retina retinal nerve fiber layer (RNFL) thickness Science & Technology Tomography |
| title | Retinal Nerve Fiber Layer Thickness and Oxidative Stress Parameters in Migraine Patients without Aura: A Pilot Study |
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