Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk

Inhibitory interneurons orchestrate information flow across the cortex and are implicated in psychiatric illness. Although interneuron classes have unique functional properties and spatial distributions, the influence of interneuron subtypes on brain function, cortical specialization, and illness ri...

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Veröffentlicht in:	Nature communications 2020-06, Vol.11 (1), p.2889-2889, Article 2889
Hauptverfasser:	Anderson, Kevin M., Collins, Meghan A., Chin, Rowena, Ge, Tian, Rosenberg, Monica D., Holmes, Avram J.
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/39 38/43 59/36 631/208/199 631/378/1689/1799 631/378/2649 Adult Amplitudes Animals Brain Brain - cytology Brain - diagnostic imaging Brain - metabolism Female Functional magnetic resonance imaging Gene Expression Profiling - methods Genes Genome-Wide Association Study - methods Humanities and Social Sciences Humans Illnesses Information flow Interneurons Interneurons - cytology Interneurons - metabolism Magnetic Resonance Imaging Male Markers Mental disorders Middle Aged multidisciplinary Multidisciplinary Sciences Neuroimaging Parvalbumin Parvalbumins - genetics Parvalbumins - metabolism Polymorphism, Single Nucleotide Primates Risk Risk Factors Schizophrenia Schizophrenia - diagnosis Schizophrenia - genetics Schizophrenia - metabolism Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Single-Cell Analysis - methods Somatostatin Somatostatin - genetics Somatostatin - metabolism Spatial distribution Specialization Transcription Young Adult
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