Gentle stroking stimuli induce affiliative responsiveness to humans in male rats
Gentle tactile stimuli have been shown to play an important role in the establishment and maintenance of affiliative social interactions. Oxytocin has also been shown to have similar actions. We investigated the effects of gentle stroking on affiliative relationships between humans and rats and the...
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| Veröffentlicht in: | Scientific reports 2020-06, Vol.10 (1), p.9135-9135, Article 9135 |
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| description | Gentle tactile stimuli have been shown to play an important role in the establishment and maintenance of affiliative social interactions. Oxytocin has also been shown to have similar actions. We investigated the effects of gentle stroking on affiliative relationships between humans and rats and the effects of gentle stroking on activation of oxytocin neurons. Male rats received 5-min stroking stimuli from an experimenter every other day for 4 weeks between 3 and 6 weeks of age (S3–6 group), for 4 weeks between 7 and 10 weeks of age (S7–10 group), or for 8 weeks between 3 and 10 weeks of age (S3–10 group). Control rats did not receive stroking stimuli. Rats in the S7–10 and S3–10 groups emitted 50-kHz calls, an index of positive emotion, more frequently during stroking stimuli. Rats in the S3–6, S7–10, and S3–10 groups showed affiliative behaviors toward the experimenter. Oxytocin neurons in the hypothalamic paraventricular nucleus of rats in the S3–6, S7–10, and S3–10 groups were activated following stroking stimuli. These findings revealed that post-weaning repeated stroking stimuli induce an affiliative relationship between rats and humans and activation of oxytocin neurons. |
| doi_str_mv | 10.1038/s41598-020-66078-7 |
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Oxytocin has also been shown to have similar actions. We investigated the effects of gentle stroking on affiliative relationships between humans and rats and the effects of gentle stroking on activation of oxytocin neurons. Male rats received 5-min stroking stimuli from an experimenter every other day for 4 weeks between 3 and 6 weeks of age (S3–6 group), for 4 weeks between 7 and 10 weeks of age (S7–10 group), or for 8 weeks between 3 and 10 weeks of age (S3–10 group). Control rats did not receive stroking stimuli. Rats in the S7–10 and S3–10 groups emitted 50-kHz calls, an index of positive emotion, more frequently during stroking stimuli. Rats in the S3–6, S7–10, and S3–10 groups showed affiliative behaviors toward the experimenter. Oxytocin neurons in the hypothalamic paraventricular nucleus of rats in the S3–6, S7–10, and S3–10 groups were activated following stroking stimuli. These findings revealed that post-weaning repeated stroking stimuli induce an affiliative relationship between rats and humans and activation of oxytocin neurons.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-66078-7</identifier><identifier>PMID: 32499488</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/51 ; 631/378/1457 ; 631/378/3919 ; Age ; Animal behavior ; Animals ; Behavior, Animal ; Humanities and Social Sciences ; Humans ; Hypothalamus ; Male ; multidisciplinary ; Neurons ; Neurons - metabolism ; Oxytocin ; Paraventricular Hypothalamic Nucleus - metabolism ; Paraventricular nucleus ; Physical Stimulation ; Proto-Oncogene Proteins c-fos - metabolism ; Rats ; Rats, Inbred Lew ; Rodents ; Science ; Science (multidisciplinary) ; Social behavior ; Social interactions ; Tactile stimuli ; Touch ; Vocalization, Animal ; Weaning</subject><ispartof>Scientific reports, 2020-06, Vol.10 (1), p.9135-9135, Article 9135</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. 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Oxytocin has also been shown to have similar actions. We investigated the effects of gentle stroking on affiliative relationships between humans and rats and the effects of gentle stroking on activation of oxytocin neurons. Male rats received 5-min stroking stimuli from an experimenter every other day for 4 weeks between 3 and 6 weeks of age (S3–6 group), for 4 weeks between 7 and 10 weeks of age (S7–10 group), or for 8 weeks between 3 and 10 weeks of age (S3–10 group). Control rats did not receive stroking stimuli. Rats in the S7–10 and S3–10 groups emitted 50-kHz calls, an index of positive emotion, more frequently during stroking stimuli. Rats in the S3–6, S7–10, and S3–10 groups showed affiliative behaviors toward the experimenter. Oxytocin neurons in the hypothalamic paraventricular nucleus of rats in the S3–6, S7–10, and S3–10 groups were activated following stroking stimuli. These findings revealed that post-weaning repeated stroking stimuli induce an affiliative relationship between rats and humans and activation of oxytocin neurons.</description><subject>13/51</subject><subject>631/378/1457</subject><subject>631/378/3919</subject><subject>Age</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hypothalamus</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Neurons</subject><subject>Neurons - metabolism</subject><subject>Oxytocin</subject><subject>Paraventricular Hypothalamic Nucleus - metabolism</subject><subject>Paraventricular nucleus</subject><subject>Physical Stimulation</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Rodents</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Social behavior</subject><subject>Social interactions</subject><subject>Tactile stimuli</subject><subject>Touch</subject><subject>Vocalization, Animal</subject><subject>Weaning</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUFPFjEQhhujEYL8AQ9kEy9eFrvTdru9kBiiQEKiBz033d3pR2G3_ejskvDvLX4I6MFeOsk887bvvIy9b_hxw0X3iWSjTFdz4HXbct3V-hXbBy5VDQLg9Yt6jx0SXfNyFBjZmLdsT4A0RnbdPvt-hnGZsKIlp5sQN6UI8zqFKsRxHbBy3ocpuCXcYZWRtilSKSMSVUuqrtbZRSpsNbsikt1C79gb7ybCw8f7gP38-uXH6Xl9-e3s4vTzZT0oyZdaGydMA370SonBeaN70TfgOuERoAU3jv3ge4PQSterQQAX2Cqv-g57IUdxwE52utu1n3Ecio3sJrvNYXb53iYX7N-dGK7sJt1ZDRraRhSBj48COd2uSIudAw04TS5iWsmCLHtWulMP6Id_0Ou05ljsFYqbsn5tTKFgRw05EWX0T59puH3IzO4ysyUz-zszq8vQ0UsbTyN_EiqA2AFUWnGD-fnt_8j-AiXDpAU</recordid><startdate>20200604</startdate><enddate>20200604</enddate><creator>Okabe, Shota</creator><creator>Takayanagi, Yuki</creator><creator>Yoshida, Masahide</creator><creator>Onaka, Tatsushi</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200604</creationdate><title>Gentle stroking stimuli induce affiliative responsiveness to humans in male rats</title><author>Okabe, Shota ; 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Oxytocin has also been shown to have similar actions. We investigated the effects of gentle stroking on affiliative relationships between humans and rats and the effects of gentle stroking on activation of oxytocin neurons. Male rats received 5-min stroking stimuli from an experimenter every other day for 4 weeks between 3 and 6 weeks of age (S3–6 group), for 4 weeks between 7 and 10 weeks of age (S7–10 group), or for 8 weeks between 3 and 10 weeks of age (S3–10 group). Control rats did not receive stroking stimuli. Rats in the S7–10 and S3–10 groups emitted 50-kHz calls, an index of positive emotion, more frequently during stroking stimuli. Rats in the S3–6, S7–10, and S3–10 groups showed affiliative behaviors toward the experimenter. Oxytocin neurons in the hypothalamic paraventricular nucleus of rats in the S3–6, S7–10, and S3–10 groups were activated following stroking stimuli. These findings revealed that post-weaning repeated stroking stimuli induce an affiliative relationship between rats and humans and activation of oxytocin neurons.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32499488</pmid><doi>10.1038/s41598-020-66078-7</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13/51 631/378/1457 631/378/3919 Age Animal behavior Animals Behavior, Animal Humanities and Social Sciences Humans Hypothalamus Male multidisciplinary Neurons Neurons - metabolism Oxytocin Paraventricular Hypothalamic Nucleus - metabolism Paraventricular nucleus Physical Stimulation Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Inbred Lew Rodents Science Science (multidisciplinary) Social behavior Social interactions Tactile stimuli Touch Vocalization, Animal Weaning |
| title | Gentle stroking stimuli induce affiliative responsiveness to humans in male rats |
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