1,4-Disubstituted 1 H -1,2,3-Triazoles for Renal Diseases: Studies of Viability, Anti-Inflammatory, and Antioxidant Activities

Inflammation is a hallmark of many metabolic diseases. We previously showed that ferrocene-appended 1 -1,2,3-triazole hybrids inhibit nitric oxide (NO) production in in vitro models of lipopolysaccharide-induced inflammation in the BV-2 cell. In the present study, we explored the viability, anti-inf...

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Veröffentlicht in:	International journal of molecular sciences 2020-05, Vol.21 (11)
Hauptverfasser:	Cheng, Ching-Yi, Haque, Ashanul, Hsieh, Ming-Fa, Imran Hassan, Syed, Faizi, Md Serajul Haque, Dege, Necmi, Khan, Muhammad S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Antioxidants - metabolism Antioxidants - pharmacology Cell Survival - drug effects Cellobiose - analogs & derivatives Crystallography, X-Ray Cyclooxygenase 2 - metabolism Free Radicals Group IV Phospholipases A2 - metabolism Humans Inflammation - drug therapy Kidney Diseases - drug therapy Lipopolysaccharides - pharmacology Matrix Metalloproteinase 9 - metabolism Mesangial Cells - drug effects Mesangial Cells - metabolism Mitochondria - metabolism Molecular Docking Simulation Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Rats Triazoles - pharmacology
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