Early Cognitive Impairment Behind Nigrostriatal Circuit Neurotoxicity: Are Astrocytes Involved?

Cognitive dysfunction is one of the most severe nonmotor symptoms of nigrostriatal impairment. This occurs as a result of profound functional and morphological changes of different neuronal circuits, including modifications in the plasticity and architecture of hippocampal synapses. Such alterations...

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Veröffentlicht in:	ASN neuro 2020, Vol.12 (1), p.1759091420925977
Hauptverfasser:	Herrera, Macarena L., Deza-Ponzio, Romina, Ghersi, Marisa S., de la Villarmois, Emilce A., Virgolini, Miriam B., Pérez, Mariela F., Molina, Victor A., Bellini, María J., Hereñú, Claudia B.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Aldehyde dehydrogenase Animal cognition Animal models Astrocytes Caudate-putamen Cognitive ability Dementia disorders Detoxification Dopamine Enzymes Excitability Glial fibrillary acidic protein Hippocampus Hydroxylase Immunoreactivity Long-term potentiation Memory Mitochondria Motor task performance Neurodegenerative diseases Neurotoxicity Original Paper Prefrontal cortex Putamen Short term memory Synaptic transmission
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