The Role of Ca 2+ -NFATc1 Signaling and Its Modulation on Osteoclastogenesis
The increasing of intracellular calcium concentration is a fundamental process for mediating osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium binds to calmodulin and subsequently activates calcineurin, leading to NFATc1 activation, a master transcription facto...
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| Veröffentlicht in: | International journal of molecular sciences 2020-05, Vol.21 (10) |
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| container_title | International journal of molecular sciences |
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| creator | Kang, Jung Yun Kang, Namju Yang, Yu-Mi Hong, Jeong Hee Shin, Dong Min |
| description | The increasing of intracellular calcium concentration is a fundamental process for mediating osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium binds to calmodulin and subsequently activates calcineurin, leading to NFATc1 activation, a master transcription factor required for osteoclast differentiation. Targeting the various activation processes in osteoclastogenesis provides various therapeutic strategies for bone loss. Diverse compounds that modulate calcium signaling have been applied to regulate osteoclast differentiation and, subsequently, attenuate bone loss. Thus, in this review, we summarized the modulation of the NFATc1 pathway through various compounds that regulate calcium signaling and the calcium influx machinery. Furthermore, we addressed the involvement of transient receptor potential channels in osteoclastogenesis. |
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| ispartof | International journal of molecular sciences, 2020-05, Vol.21 (10) |
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| source | MEDLINE; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Calcium Signaling Humans NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism Osteoclasts - cytology Osteoclasts - metabolism Osteogenesis Transient Receptor Potential Channels - genetics Transient Receptor Potential Channels - metabolism |
| title | The Role of Ca 2+ -NFATc1 Signaling and Its Modulation on Osteoclastogenesis |
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