A novel NAP1L4/NUTM1 fusion arising from translocation t(11;15)(p15;q12) in a myeloid neoplasm with eosinophilia and rearrangement of PDGFRA highlights an unusual clinical feature and therapeutic reaction
NUT midline carcinoma (NMC) is an aggressive neoplasm and mainly involved in the head and neck area. The defining genetic hallmark on these tumors is that testis-specific nuclear gene ( NUTM1 ) fuses to bromodomain protein family member 4 gene ( BRD4 ), resulting in the formation of BRD4-NUTM1 trans...
Gespeichert in:
| Veröffentlicht in: | Annals of hematology 2020-07, Vol.99 (7), p.1561-1564 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1564 |
|---|---|
| container_issue | 7 |
| container_start_page | 1561 |
| container_title | Annals of hematology |
| container_volume | 99 |
| creator | Cheng, Zhao Luo, Yunya Zhang, Yang Wang, Yewei Chen, Yi Xu, Yunxiao Peng, Honling Zhang, Guangsen |
| description | NUT midline carcinoma (NMC) is an aggressive neoplasm and mainly involved in the head and neck area. The defining genetic hallmark on these tumors is that testis-specific nuclear gene (
NUTM1
) fuses to bromodomain protein family member 4 gene (
BRD4
), resulting in the formation of
BRD4-NUTM1
transcript. Here, we report a case with myeloid neoplasm complicating with eosinophilia (MLN-Eo) and rearrangement of
PDGFRA
, which co-exists with a new nucleosome assemble protein 1–like 4 gene (
NAP1L4
)
NAP1L4-NUTM1
fusion. The patient have unusually clinical features and therapeutic reaction to imatinib mesylate. The cloned
NAP1L4-NUTM1
gene structure is also determined. |
| doi_str_mv | 10.1007/s00277-020-04000-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_32451710</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2417166507</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-824c2f60ddc2a26ee75235cfe1f04ae23183fc5486d4c404db301f2aee2c66363</originalsourceid><addsrcrecordid>eNqNkd9qFDEUxgdRbK2-gBcS8KZFxp78m5nSq2W1VVhrkfZ6yGZOdlNmkmmSse07-lBmd2u9EwMhB_L7vnOSryjeUvhIAerjCMDqugQGJQgAKO-fFftUcFaCbMTzYh9O-Ekp89orXsV4A0BZI9jLYo8zIWlNYb_4NSPO_8SeXMwu6UIcX1xffaPETNF6R1Sw0boVMcEPJAXlYu-1SpurdEjpKZVHhyOVp7eUHRGbeTI8YO9tRxz6sVdxIHc2rQn6bOPHte2tIsp1JKAK2W6FA7pEvCGXn87PfszI2q7Wfd4pZoxMboqT6onurbM6FwZVmgJuLdIagxpxSlZv7PRmqtfFC6P6iG8ez4Pi-uzz1fxLufh-_nU-W5Sa1zKVDROamQq6TjPFKsRaMi61QWpAKGScNtxoKZqqE1qA6JYcqGEKkemq4hU_KN7vfMfgbyeMqb3xU3C5ZctE_teqklBniu0oHXyMAU07Bjuo8NBSaDcBtrsA2xxguw2wvc-id4_W03LA7knyJ7EMNDvgDpfeRG3RaXzCsonkUnBZ5wr43KZtXHM_uZSlH_5fmmm-o2MmclTh7yP_Mf9vGGXIVA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2417166507</pqid></control><display><type>article</type><title>A novel NAP1L4/NUTM1 fusion arising from translocation t(11;15)(p15;q12) in a myeloid neoplasm with eosinophilia and rearrangement of PDGFRA highlights an unusual clinical feature and therapeutic reaction</title><source>SpringerLink</source><source>Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Cheng, Zhao ; Luo, Yunya ; Zhang, Yang ; Wang, Yewei ; Chen, Yi ; Xu, Yunxiao ; Peng, Honling ; Zhang, Guangsen</creator><creatorcontrib>Cheng, Zhao ; Luo, Yunya ; Zhang, Yang ; Wang, Yewei ; Chen, Yi ; Xu, Yunxiao ; Peng, Honling ; Zhang, Guangsen</creatorcontrib><description>NUT midline carcinoma (NMC) is an aggressive neoplasm and mainly involved in the head and neck area. The defining genetic hallmark on these tumors is that testis-specific nuclear gene (
NUTM1
) fuses to bromodomain protein family member 4 gene (
BRD4
), resulting in the formation of
BRD4-NUTM1
transcript. Here, we report a case with myeloid neoplasm complicating with eosinophilia (MLN-Eo) and rearrangement of
PDGFRA
, which co-exists with a new nucleosome assemble protein 1–like 4 gene (
NAP1L4
)
NAP1L4-NUTM1
fusion. The patient have unusually clinical features and therapeutic reaction to imatinib mesylate. The cloned
NAP1L4-NUTM1
gene structure is also determined.</description><identifier>ISSN: 0939-5555</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-020-04000-x</identifier><identifier>PMID: 32451710</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Blood diseases ; Hematology ; Life Sciences & Biomedicine ; Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Science & Technology ; Tumors</subject><ispartof>Annals of hematology, 2020-07, Vol.99 (7), p.1561-1564</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>12</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000535435700003</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c375t-824c2f60ddc2a26ee75235cfe1f04ae23183fc5486d4c404db301f2aee2c66363</citedby><cites>FETCH-LOGICAL-c375t-824c2f60ddc2a26ee75235cfe1f04ae23183fc5486d4c404db301f2aee2c66363</cites><orcidid>0009-0002-7413-2463</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00277-020-04000-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00277-020-04000-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,28253,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32451710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Zhao</creatorcontrib><creatorcontrib>Luo, Yunya</creatorcontrib><creatorcontrib>Zhang, Yang</creatorcontrib><creatorcontrib>Wang, Yewei</creatorcontrib><creatorcontrib>Chen, Yi</creatorcontrib><creatorcontrib>Xu, Yunxiao</creatorcontrib><creatorcontrib>Peng, Honling</creatorcontrib><creatorcontrib>Zhang, Guangsen</creatorcontrib><title>A novel NAP1L4/NUTM1 fusion arising from translocation t(11;15)(p15;q12) in a myeloid neoplasm with eosinophilia and rearrangement of PDGFRA highlights an unusual clinical feature and therapeutic reaction</title><title>Annals of hematology</title><addtitle>Ann Hematol</addtitle><addtitle>ANN HEMATOL</addtitle><addtitle>Ann Hematol</addtitle><description>NUT midline carcinoma (NMC) is an aggressive neoplasm and mainly involved in the head and neck area. The defining genetic hallmark on these tumors is that testis-specific nuclear gene (
NUTM1
) fuses to bromodomain protein family member 4 gene (
BRD4
), resulting in the formation of
BRD4-NUTM1
transcript. Here, we report a case with myeloid neoplasm complicating with eosinophilia (MLN-Eo) and rearrangement of
PDGFRA
, which co-exists with a new nucleosome assemble protein 1–like 4 gene (
NAP1L4
)
NAP1L4-NUTM1
fusion. The patient have unusually clinical features and therapeutic reaction to imatinib mesylate. The cloned
NAP1L4-NUTM1
gene structure is also determined.</description><subject>Blood diseases</subject><subject>Hematology</subject><subject>Life Sciences & Biomedicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Science & Technology</subject><subject>Tumors</subject><issn>0939-5555</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkd9qFDEUxgdRbK2-gBcS8KZFxp78m5nSq2W1VVhrkfZ6yGZOdlNmkmmSse07-lBmd2u9EwMhB_L7vnOSryjeUvhIAerjCMDqugQGJQgAKO-fFftUcFaCbMTzYh9O-Ekp89orXsV4A0BZI9jLYo8zIWlNYb_4NSPO_8SeXMwu6UIcX1xffaPETNF6R1Sw0boVMcEPJAXlYu-1SpurdEjpKZVHhyOVp7eUHRGbeTI8YO9tRxz6sVdxIHc2rQn6bOPHte2tIsp1JKAK2W6FA7pEvCGXn87PfszI2q7Wfd4pZoxMboqT6onurbM6FwZVmgJuLdIagxpxSlZv7PRmqtfFC6P6iG8ez4Pi-uzz1fxLufh-_nU-W5Sa1zKVDROamQq6TjPFKsRaMi61QWpAKGScNtxoKZqqE1qA6JYcqGEKkemq4hU_KN7vfMfgbyeMqb3xU3C5ZctE_teqklBniu0oHXyMAU07Bjuo8NBSaDcBtrsA2xxguw2wvc-id4_W03LA7knyJ7EMNDvgDpfeRG3RaXzCsonkUnBZ5wr43KZtXHM_uZSlH_5fmmm-o2MmclTh7yP_Mf9vGGXIVA</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Cheng, Zhao</creator><creator>Luo, Yunya</creator><creator>Zhang, Yang</creator><creator>Wang, Yewei</creator><creator>Chen, Yi</creator><creator>Xu, Yunxiao</creator><creator>Peng, Honling</creator><creator>Zhang, Guangsen</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0009-0002-7413-2463</orcidid></search><sort><creationdate>20200701</creationdate><title>A novel NAP1L4/NUTM1 fusion arising from translocation t(11;15)(p15;q12) in a myeloid neoplasm with eosinophilia and rearrangement of PDGFRA highlights an unusual clinical feature and therapeutic reaction</title><author>Cheng, Zhao ; Luo, Yunya ; Zhang, Yang ; Wang, Yewei ; Chen, Yi ; Xu, Yunxiao ; Peng, Honling ; Zhang, Guangsen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-824c2f60ddc2a26ee75235cfe1f04ae23183fc5486d4c404db301f2aee2c66363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Blood diseases</topic><topic>Hematology</topic><topic>Life Sciences & Biomedicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Science & Technology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Zhao</creatorcontrib><creatorcontrib>Luo, Yunya</creatorcontrib><creatorcontrib>Zhang, Yang</creatorcontrib><creatorcontrib>Wang, Yewei</creatorcontrib><creatorcontrib>Chen, Yi</creatorcontrib><creatorcontrib>Xu, Yunxiao</creatorcontrib><creatorcontrib>Peng, Honling</creatorcontrib><creatorcontrib>Zhang, Guangsen</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Annals of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Zhao</au><au>Luo, Yunya</au><au>Zhang, Yang</au><au>Wang, Yewei</au><au>Chen, Yi</au><au>Xu, Yunxiao</au><au>Peng, Honling</au><au>Zhang, Guangsen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel NAP1L4/NUTM1 fusion arising from translocation t(11;15)(p15;q12) in a myeloid neoplasm with eosinophilia and rearrangement of PDGFRA highlights an unusual clinical feature and therapeutic reaction</atitle><jtitle>Annals of hematology</jtitle><stitle>Ann Hematol</stitle><stitle>ANN HEMATOL</stitle><addtitle>Ann Hematol</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>99</volume><issue>7</issue><spage>1561</spage><epage>1564</epage><pages>1561-1564</pages><issn>0939-5555</issn><eissn>1432-0584</eissn><abstract>NUT midline carcinoma (NMC) is an aggressive neoplasm and mainly involved in the head and neck area. The defining genetic hallmark on these tumors is that testis-specific nuclear gene (
NUTM1
) fuses to bromodomain protein family member 4 gene (
BRD4
), resulting in the formation of
BRD4-NUTM1
transcript. Here, we report a case with myeloid neoplasm complicating with eosinophilia (MLN-Eo) and rearrangement of
PDGFRA
, which co-exists with a new nucleosome assemble protein 1–like 4 gene (
NAP1L4
)
NAP1L4-NUTM1
fusion. The patient have unusually clinical features and therapeutic reaction to imatinib mesylate. The cloned
NAP1L4-NUTM1
gene structure is also determined.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32451710</pmid><doi>10.1007/s00277-020-04000-x</doi><tpages>4</tpages><orcidid>https://orcid.org/0009-0002-7413-2463</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0939-5555 |
| ispartof | Annals of hematology, 2020-07, Vol.99 (7), p.1561-1564 |
| issn | 0939-5555 1432-0584 |
| language | eng |
| recordid | cdi_pubmed_primary_32451710 |
| source | SpringerLink; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /> |
| subjects | Blood diseases Hematology Life Sciences & Biomedicine Medicine Medicine & Public Health Oncology Original Article Science & Technology Tumors |
| title | A novel NAP1L4/NUTM1 fusion arising from translocation t(11;15)(p15;q12) in a myeloid neoplasm with eosinophilia and rearrangement of PDGFRA highlights an unusual clinical feature and therapeutic reaction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T16%3A31%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20novel%20NAP1L4/NUTM1%20fusion%20arising%20from%20translocation%20t(11;15)(p15;q12)%20in%20a%20myeloid%20neoplasm%20with%20eosinophilia%20and%20rearrangement%20of%20PDGFRA%20highlights%20an%20unusual%20clinical%20feature%20and%20therapeutic%20reaction&rft.jtitle=Annals%20of%20hematology&rft.au=Cheng,%20Zhao&rft.date=2020-07-01&rft.volume=99&rft.issue=7&rft.spage=1561&rft.epage=1564&rft.pages=1561-1564&rft.issn=0939-5555&rft.eissn=1432-0584&rft_id=info:doi/10.1007/s00277-020-04000-x&rft_dat=%3Cproquest_pubme%3E2417166507%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2417166507&rft_id=info:pmid/32451710&rfr_iscdi=true |