A study of the outward background current conductance g K1 , the pacemaker current conductance g f , and the gap junction conductance g j as determinants of biological pacing in single cells and in a two-cell syncytium using the dynamic clamp

We previously demonstrated that a two-cell syncytium, composed of a ventricular myocyte and an mHCN2 expressing cell, recapitulated most properties of in vivo biological pacing induced by mHCN2-transfected hMSCs in the canine ventricle. Here, we use the two-cell syncytium, employing dynamic clamp, t...

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Veröffentlicht in:	Pflügers Archiv 2020-05, Vol.472 (5), p.561
Hauptverfasser:	Valiunas, Virginijus, Cohen, Ira S, Brink, Peter R, Clausen, Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Clocks Gap Junctions - physiology Giant Cells - cytology Giant Cells - physiology HEK293 Cells Humans Membrane Potentials NAV1.5 Voltage-Gated Sodium Channel - metabolism
Online-Zugang:	Volltext
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