Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan

An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respirator...

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Veröffentlicht in:	Emerging infectious diseases 2020-09, Vol.26 (9), p.2157-2161
Hauptverfasser:	Adachi, Takuya, Chong, Ja-Mun, Nakajima, Noriko, Sano, Masahiro, Yamazaki, Jun, Miyamoto, Ippei, Nishioka, Haruka, Akita, Hidetaka, Sato, Yuko, Kataoka, Michiyo, Katano, Harutaka, Tobiume, Minoru, Sekizuka, Tsuyoshi, Itokawa, Kentaro, Kuroda, Makoto, Suzuki, Tadaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged, 80 and over Alveolar Epithelial Cells - pathology Alveolar Epithelial Cells - virology Antigens Autopsy Betacoronavirus Clinicopathologic and Immunohistochemical Findings from Autopsy of Patient with COVID-19, Japan Coronavirus Infections - pathology Coronavirus Infections - virology Coronaviruses COVID-19 cruise Dehydrogenases diffuse alveolar damage Disease transmission Dispatch Dyspnea Epidemics Female Grants Health aspects Hospitals Humans Illnesses Immunohistochemistry Immunology Infectious Diseases Japan Laboratories Life Sciences & Biomedicine Lung - pathology Lung - virology Lungs Medical research Membranes Methicillin Mutation Pandemics Pathology Pneumonia, Viral - pathology Pneumonia, Viral - virology R&D Research & development SARS-CoV-2 Science & Technology Severe acute respiratory syndrome coronavirus 2 Sulbactam Throat Tropical diseases
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Zusammenfassung:	An autopsy of a patient in Japan with coronavirus disease indicated pneumonia lung pathology, manifested as diffuse alveolar damage. We detected severe acute respiratory syndrome coronavirus 2 antigen in alveolar epithelial cells and macrophages. Coronavirus disease is essentially a lower respiratory tract disease characterized by direct viral injury of alveolar epithelial cells.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2609.201353