Dynamic inflammatory response in a critically ill COVID-19 patient treated with corticosteroids
To investigate the effect of corticosteroids therapy on the inflammatory response in a critically ill coronavirus disease 2019 (COVID-19) patient. A 55-year old female patient with critical ill COVID-19 was admitted in Taizhou Hospital on January 19, 2020. The patient was treated with methylpredniso...
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| Veröffentlicht in: | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban 2020-05, Vol.49 (2), p.220 |
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| container_title | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban |
| container_volume | 49 |
| creator | Zhagn, Sheng Li, Danping Chen, Huazhong Zheng, Dan Zhou, Yiping Chen, Baoguo Shi, Weiwu Lin, Ronghai |
| description | To investigate the effect of corticosteroids therapy on the inflammatory response in a critically ill coronavirus disease 2019 (COVID-19) patient.
A 55-year old female patient with critical ill COVID-19 was admitted in Taizhou Hospital on January 19, 2020. The patient was treated with methylprednisolone 80 mg on the 2nd day after admission. Thereafter, the dose was adjusted in a timely manner and the therapy lasted for 13 days. The peripheral lymphocyte subsets (CD3
T, CD4
T, CD8
T, NK cells, B cells), as well as serum levels of lymphocyte factors (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ) were dynamically monitored.
On D1 of admission, the numbers of peripheral blood CD3
T, CD4
T, CD8
T, and NK cells were significantly lower than the normal range. With the improvement of the disease, the numbers of CD3
T, CD8
T and CD4
T cells gradually recovered and showed a linear growth trend (linear fitting equation:
=18.59
+109.4, |
| doi_str_mv | 10.3785/j.issn.1008-9292.2020.03.10 |
| format | Article |
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A 55-year old female patient with critical ill COVID-19 was admitted in Taizhou Hospital on January 19, 2020. The patient was treated with methylprednisolone 80 mg on the 2nd day after admission. Thereafter, the dose was adjusted in a timely manner and the therapy lasted for 13 days. The peripheral lymphocyte subsets (CD3
T, CD4
T, CD8
T, NK cells, B cells), as well as serum levels of lymphocyte factors (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ) were dynamically monitored.
On D1 of admission, the numbers of peripheral blood CD3
T, CD4
T, CD8
T, and NK cells were significantly lower than the normal range. With the improvement of the disease, the numbers of CD3
T, CD8
T and CD4
T cells gradually recovered and showed a linear growth trend (linear fitting equation:
=18.59
+109.4,
<0.05). On D2 of admission, the patient's IL-6 and IL-10 levels were significantly higher tha</description><identifier>ISSN: 1008-9292</identifier><identifier>DOI: 10.3785/j.issn.1008-9292.2020.03.10</identifier><identifier>PMID: 32391668</identifier><language>chi</language><publisher>China</publisher><subject>Betacoronavirus - isolation & purification ; Cell Count ; Coronavirus Infections - diagnosis ; Coronavirus Infections - drug therapy ; Coronavirus Infections - immunology ; Coronavirus Infections - physiopathology ; COVID-19 ; Critical Illness ; Cytokines - blood ; Female ; Humans ; Methylprednisolone - administration & dosage ; Methylprednisolone - adverse effects ; Middle Aged ; Pandemics ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - drug therapy ; Pneumonia, Viral - immunology ; Pneumonia, Viral - physiopathology ; SARS-CoV-2 ; T-Lymphocyte Subsets - drug effects ; Treatment Outcome</subject><ispartof>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2020-05, Vol.49 (2), p.220</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32391668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhagn, Sheng</creatorcontrib><creatorcontrib>Li, Danping</creatorcontrib><creatorcontrib>Chen, Huazhong</creatorcontrib><creatorcontrib>Zheng, Dan</creatorcontrib><creatorcontrib>Zhou, Yiping</creatorcontrib><creatorcontrib>Chen, Baoguo</creatorcontrib><creatorcontrib>Shi, Weiwu</creatorcontrib><creatorcontrib>Lin, Ronghai</creatorcontrib><title>Dynamic inflammatory response in a critically ill COVID-19 patient treated with corticosteroids</title><title>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</title><addtitle>Zhejiang Da Xue Xue Bao Yi Xue Ban</addtitle><description>To investigate the effect of corticosteroids therapy on the inflammatory response in a critically ill coronavirus disease 2019 (COVID-19) patient.
A 55-year old female patient with critical ill COVID-19 was admitted in Taizhou Hospital on January 19, 2020. The patient was treated with methylprednisolone 80 mg on the 2nd day after admission. Thereafter, the dose was adjusted in a timely manner and the therapy lasted for 13 days. The peripheral lymphocyte subsets (CD3
T, CD4
T, CD8
T, NK cells, B cells), as well as serum levels of lymphocyte factors (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ) were dynamically monitored.
On D1 of admission, the numbers of peripheral blood CD3
T, CD4
T, CD8
T, and NK cells were significantly lower than the normal range. With the improvement of the disease, the numbers of CD3
T, CD8
T and CD4
T cells gradually recovered and showed a linear growth trend (linear fitting equation:
=18.59
+109.4,
<0.05). On D2 of admission, the patient's IL-6 and IL-10 levels were significantly higher tha</description><subject>Betacoronavirus - isolation & purification</subject><subject>Cell Count</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - drug therapy</subject><subject>Coronavirus Infections - immunology</subject><subject>Coronavirus Infections - physiopathology</subject><subject>COVID-19</subject><subject>Critical Illness</subject><subject>Cytokines - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Methylprednisolone - administration & dosage</subject><subject>Methylprednisolone - adverse effects</subject><subject>Middle Aged</subject><subject>Pandemics</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Pneumonia, Viral - drug therapy</subject><subject>Pneumonia, Viral - immunology</subject><subject>Pneumonia, Viral - physiopathology</subject><subject>SARS-CoV-2</subject><subject>T-Lymphocyte Subsets - drug effects</subject><subject>Treatment Outcome</subject><issn>1008-9292</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j0tLxDAYRbNQnGGcvyAB161fnk2W0vExMDAbdVuSNMVIXyQR6b-34IO7uHA4XLgI3RIoWaXE3UcZUhpLAqAKTTUtKVAoga3kAm3_8QbtUwoWBGHVGrhCG0aZJlKqLWoOy2iG4HAYu94Mg8lTXHD0aZ7G5FeKDXYx5OBM3y849D2uz2_HQ0E0nk0Ofsw4R2-yb_FXyO_YTXGVp5R9nEKbrtFlZ_rk97-9Q6-PDy_1c3E6Px3r-1MxEypzYUF2THCrFKWt9UoLqUAaWnlinSaUd61ZDSmgqgQ4IS3lmgrOmZGKW2A7dPOzO3_awbfNHMNg4tL8PWXfzf5Xbg</recordid><startdate>20200525</startdate><enddate>20200525</enddate><creator>Zhagn, Sheng</creator><creator>Li, Danping</creator><creator>Chen, Huazhong</creator><creator>Zheng, Dan</creator><creator>Zhou, Yiping</creator><creator>Chen, Baoguo</creator><creator>Shi, Weiwu</creator><creator>Lin, Ronghai</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20200525</creationdate><title>Dynamic inflammatory response in a critically ill COVID-19 patient treated with corticosteroids</title><author>Zhagn, Sheng ; Li, Danping ; Chen, Huazhong ; Zheng, Dan ; Zhou, Yiping ; Chen, Baoguo ; Shi, Weiwu ; Lin, Ronghai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-b06f354b8822dbe8956806a27e1bc9124fda6f36507750c56b24925443a684b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2020</creationdate><topic>Betacoronavirus - isolation & purification</topic><topic>Cell Count</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - drug therapy</topic><topic>Coronavirus Infections - immunology</topic><topic>Coronavirus Infections - physiopathology</topic><topic>COVID-19</topic><topic>Critical Illness</topic><topic>Cytokines - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Methylprednisolone - administration & dosage</topic><topic>Methylprednisolone - adverse effects</topic><topic>Middle Aged</topic><topic>Pandemics</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Pneumonia, Viral - drug therapy</topic><topic>Pneumonia, Viral - immunology</topic><topic>Pneumonia, Viral - physiopathology</topic><topic>SARS-CoV-2</topic><topic>T-Lymphocyte Subsets - drug effects</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhagn, Sheng</creatorcontrib><creatorcontrib>Li, Danping</creatorcontrib><creatorcontrib>Chen, Huazhong</creatorcontrib><creatorcontrib>Zheng, Dan</creatorcontrib><creatorcontrib>Zhou, Yiping</creatorcontrib><creatorcontrib>Chen, Baoguo</creatorcontrib><creatorcontrib>Shi, Weiwu</creatorcontrib><creatorcontrib>Lin, Ronghai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhagn, Sheng</au><au>Li, Danping</au><au>Chen, Huazhong</au><au>Zheng, Dan</au><au>Zhou, Yiping</au><au>Chen, Baoguo</au><au>Shi, Weiwu</au><au>Lin, Ronghai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic inflammatory response in a critically ill COVID-19 patient treated with corticosteroids</atitle><jtitle>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</jtitle><addtitle>Zhejiang Da Xue Xue Bao Yi Xue Ban</addtitle><date>2020-05-25</date><risdate>2020</risdate><volume>49</volume><issue>2</issue><spage>220</spage><pages>220-</pages><issn>1008-9292</issn><abstract>To investigate the effect of corticosteroids therapy on the inflammatory response in a critically ill coronavirus disease 2019 (COVID-19) patient.
A 55-year old female patient with critical ill COVID-19 was admitted in Taizhou Hospital on January 19, 2020. The patient was treated with methylprednisolone 80 mg on the 2nd day after admission. Thereafter, the dose was adjusted in a timely manner and the therapy lasted for 13 days. The peripheral lymphocyte subsets (CD3
T, CD4
T, CD8
T, NK cells, B cells), as well as serum levels of lymphocyte factors (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ) were dynamically monitored.
On D1 of admission, the numbers of peripheral blood CD3
T, CD4
T, CD8
T, and NK cells were significantly lower than the normal range. With the improvement of the disease, the numbers of CD3
T, CD8
T and CD4
T cells gradually recovered and showed a linear growth trend (linear fitting equation:
=18.59
+109.4,
<0.05). On D2 of admission, the patient's IL-6 and IL-10 levels were significantly higher tha</abstract><cop>China</cop><pmid>32391668</pmid><doi>10.3785/j.issn.1008-9292.2020.03.10</doi></addata></record> |
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| identifier | ISSN: 1008-9292 |
| ispartof | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2020-05, Vol.49 (2), p.220 |
| issn | 1008-9292 |
| language | chi |
| recordid | cdi_pubmed_primary_32391668 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Betacoronavirus - isolation & purification Cell Count Coronavirus Infections - diagnosis Coronavirus Infections - drug therapy Coronavirus Infections - immunology Coronavirus Infections - physiopathology COVID-19 Critical Illness Cytokines - blood Female Humans Methylprednisolone - administration & dosage Methylprednisolone - adverse effects Middle Aged Pandemics Pneumonia, Viral - diagnosis Pneumonia, Viral - drug therapy Pneumonia, Viral - immunology Pneumonia, Viral - physiopathology SARS-CoV-2 T-Lymphocyte Subsets - drug effects Treatment Outcome |
| title | Dynamic inflammatory response in a critically ill COVID-19 patient treated with corticosteroids |
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