Activation of PPAR-γ induces macrophage polarization and reduces neutrophil migration mediated by heme oxygenase 1

•Macrophages are one of the main cellular targets for PPAR-γ activation when peripherally administered.•Anti-inflammatory features of PPAR-γ activation by 15d-PGJ2 are related to M2-like polarization.•HO-1 is crucial for macrophage polarization and for preventing recruitment of animal and human neut...

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Veröffentlicht in:	International immunopharmacology 2020-07, Vol.84, p.106565-106565, Article 106565
Hauptverfasser:	Abdalla, Henrique Ballassini, Napimoga, Marcelo Henrique, Lopes, Alexandre Hashimoto, de Macedo Maganin, Alexandre Gomes, Cunha, Thiago Mattar, Van Dyke, Thomas E., Clemente Napimoga, Juliana Trindade
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Anilides - pharmacology Animals Arginine Bone marrow Calcium ions Calcium-binding protein Calcium-Calmodulin-Dependent Protein Kinase Type 2 - immunology Calmodulin Carrageenan Carrageenan - pharmacology Cell activation Cell Movement - drug effects Cells, Cultured Cyclic GMP Cytokines Cytokines - immunology Heme Heme Oxygenase-1 - immunology Humans Inflammation Leukocyte migration Leukocytes Lipopolysaccharides - pharmacology Macrophages Macrophages - drug effects Macrophages - immunology Male Mice, Inbred C57BL Narcotics Neutrophils Neutrophils - drug effects Neutrophils - physiology Nitric Oxide - immunology Opioids Oxygenase Pain Peroxisome proliferator-activated receptors Polarization PPAR gamma - immunology Prostaglandin D2 - analogs & derivatives Prostaglandin D2 - pharmacology Rats, Wistar Rodents Temporomandibular joint Temporomandibular Joint - drug effects Temporomandibular Joint - immunology
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