Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis
Developing dermatitis therapeutics has been faced with challenges including adverse effects of topical steroid and high cost of new developing drugs. Here, we found the expression levels of dopamine receptor D2 is higher in skin biopsies of dermatitis patients and an oxazolone-induced animal model o...
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| Veröffentlicht in: | International journal of molecular sciences 2020-05, Vol.21 (9), p.3241, Article 3241 |
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| creator | Heo, Min-Jeong Choi, Soo Young Lee, Chanmi Choi, Yeong Min An, In-sook Bae, Seunghee An, Sungkwan Jung, Jin Hyuk |
| description | Developing dermatitis therapeutics has been faced with challenges including adverse effects of topical steroid and high cost of new developing drugs. Here, we found the expression levels of dopamine receptor D2 is higher in skin biopsies of dermatitis patients and an oxazolone-induced animal model of dermatitis. We used perphenazine, an FDA-approved dopamine receptor antagonist to determine the therapeutic effect. Two different animal models including 12-o-tetradecanoylphorbol-13-acetate (TPA) and oxazolone (OXA)-induced dermatitis were employed. TPA and OXA-mediated ear swelling was attenuated by perphenazine. Moreover, perphenazine inhibited infiltrated mast cells into lesion area. We found levels of serum IgE, histamine and cytokines are decreased in mice cotreated with perphenazine and OXA compared to OXA-treated mice. Overall, this is a first study showing that the FDA-approved, anti-psychotic drug, perphenazine, alleviates animal models of dermatitis. |
| doi_str_mv | 10.3390/ijms21093241 |
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Here, we found the expression levels of dopamine receptor D2 is higher in skin biopsies of dermatitis patients and an oxazolone-induced animal model of dermatitis. We used perphenazine, an FDA-approved dopamine receptor antagonist to determine the therapeutic effect. Two different animal models including 12-o-tetradecanoylphorbol-13-acetate (TPA) and oxazolone (OXA)-induced dermatitis were employed. TPA and OXA-mediated ear swelling was attenuated by perphenazine. Moreover, perphenazine inhibited infiltrated mast cells into lesion area. We found levels of serum IgE, histamine and cytokines are decreased in mice cotreated with perphenazine and OXA compared to OXA-treated mice. Overall, this is a first study showing that the FDA-approved, anti-psychotic drug, perphenazine, alleviates animal models of dermatitis.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21093241</identifier><identifier>PMID: 32375285</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>12-O-Tetradecanoylphorbol-13-acetate ; Acetic acid ; Animal models ; Animals ; Biochemistry & Molecular Biology ; Chemistry ; Chemistry, Multidisciplinary ; Cytokines ; Cytokines - metabolism ; Dermatitis ; Dermatitis, Allergic Contact - drug therapy ; Dermatitis, Allergic Contact - etiology ; Dopamine ; Dopamine Antagonists - pharmacology ; Dopamine Antagonists - therapeutic use ; Dopamine D2 receptors ; dopamine receptor D2 ; drug repurposing ; Histamine ; Immunoglobulin E ; Immunoglobulin G - metabolism ; Inflammation ; Laboratory animals ; Life Sciences & Biomedicine ; Lymphocytes ; Lymphocytes T ; Mast cells ; Mast Cells - drug effects ; Mast Cells - immunology ; Metabolism ; Mice ; Mice, Inbred C57BL ; NIH 3T3 Cells ; Oxazolone - toxicity ; Perphenazine ; Perphenazine - pharmacology ; Perphenazine - therapeutic use ; Physical Sciences ; Quarantine ; Science & Technology ; Steroids ; Tetradecanoylphorbol Acetate - toxicity ; Th2 Cells - drug effects ; Th2 Cells - immunology</subject><ispartof>International journal of molecular sciences, 2020-05, Vol.21 (9), p.3241, Article 3241</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000535581700212</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c478t-130197a91e191b2f0c07a9d24cbb06678b050946d026776feda549d98de006143</citedby><cites>FETCH-LOGICAL-c478t-130197a91e191b2f0c07a9d24cbb06678b050946d026776feda549d98de006143</cites><orcidid>0000-0002-2811-8305</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247351/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247351/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,28253,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32375285$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heo, Min-Jeong</creatorcontrib><creatorcontrib>Choi, Soo Young</creatorcontrib><creatorcontrib>Lee, Chanmi</creatorcontrib><creatorcontrib>Choi, Yeong Min</creatorcontrib><creatorcontrib>An, In-sook</creatorcontrib><creatorcontrib>Bae, Seunghee</creatorcontrib><creatorcontrib>An, Sungkwan</creatorcontrib><creatorcontrib>Jung, Jin Hyuk</creatorcontrib><title>Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis</title><title>International journal of molecular sciences</title><addtitle>INT J MOL SCI</addtitle><addtitle>Int J Mol Sci</addtitle><description>Developing dermatitis therapeutics has been faced with challenges including adverse effects of topical steroid and high cost of new developing drugs. Here, we found the expression levels of dopamine receptor D2 is higher in skin biopsies of dermatitis patients and an oxazolone-induced animal model of dermatitis. We used perphenazine, an FDA-approved dopamine receptor antagonist to determine the therapeutic effect. Two different animal models including 12-o-tetradecanoylphorbol-13-acetate (TPA) and oxazolone (OXA)-induced dermatitis were employed. TPA and OXA-mediated ear swelling was attenuated by perphenazine. Moreover, perphenazine inhibited infiltrated mast cells into lesion area. We found levels of serum IgE, histamine and cytokines are decreased in mice cotreated with perphenazine and OXA compared to OXA-treated mice. 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metabolism</topic><topic>Dermatitis</topic><topic>Dermatitis, Allergic Contact - drug therapy</topic><topic>Dermatitis, Allergic Contact - etiology</topic><topic>Dopamine</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Dopamine Antagonists - therapeutic use</topic><topic>Dopamine D2 receptors</topic><topic>dopamine receptor D2</topic><topic>drug repurposing</topic><topic>Histamine</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin G - metabolism</topic><topic>Inflammation</topic><topic>Laboratory animals</topic><topic>Life Sciences & Biomedicine</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Mast cells</topic><topic>Mast Cells - drug effects</topic><topic>Mast Cells - immunology</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>NIH 3T3 Cells</topic><topic>Oxazolone - toxicity</topic><topic>Perphenazine</topic><topic>Perphenazine - pharmacology</topic><topic>Perphenazine - therapeutic use</topic><topic>Physical Sciences</topic><topic>Quarantine</topic><topic>Science & Technology</topic><topic>Steroids</topic><topic>Tetradecanoylphorbol Acetate - 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Here, we found the expression levels of dopamine receptor D2 is higher in skin biopsies of dermatitis patients and an oxazolone-induced animal model of dermatitis. We used perphenazine, an FDA-approved dopamine receptor antagonist to determine the therapeutic effect. Two different animal models including 12-o-tetradecanoylphorbol-13-acetate (TPA) and oxazolone (OXA)-induced dermatitis were employed. TPA and OXA-mediated ear swelling was attenuated by perphenazine. Moreover, perphenazine inhibited infiltrated mast cells into lesion area. We found levels of serum IgE, histamine and cytokines are decreased in mice cotreated with perphenazine and OXA compared to OXA-treated mice. Overall, this is a first study showing that the FDA-approved, anti-psychotic drug, perphenazine, alleviates animal models of dermatitis.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>32375285</pmid><doi>10.3390/ijms21093241</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2811-8305</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 12-O-Tetradecanoylphorbol-13-acetate Acetic acid Animal models Animals Biochemistry & Molecular Biology Chemistry Chemistry, Multidisciplinary Cytokines Cytokines - metabolism Dermatitis Dermatitis, Allergic Contact - drug therapy Dermatitis, Allergic Contact - etiology Dopamine Dopamine Antagonists - pharmacology Dopamine Antagonists - therapeutic use Dopamine D2 receptors dopamine receptor D2 drug repurposing Histamine Immunoglobulin E Immunoglobulin G - metabolism Inflammation Laboratory animals Life Sciences & Biomedicine Lymphocytes Lymphocytes T Mast cells Mast Cells - drug effects Mast Cells - immunology Metabolism Mice Mice, Inbred C57BL NIH 3T3 Cells Oxazolone - toxicity Perphenazine Perphenazine - pharmacology Perphenazine - therapeutic use Physical Sciences Quarantine Science & Technology Steroids Tetradecanoylphorbol Acetate - toxicity Th2 Cells - drug effects Th2 Cells - immunology |
| title | Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis |
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