A high-resolution description of β 1 -adrenergic receptor functional dynamics and allosteric coupling from backbone NMR

Signal transmission and regulation of G-protein-coupled receptors (GPCRs) by extra- and intracellular ligands occurs via modulation of complex conformational equilibria, but their exact kinetic details and underlying atomic mechanisms are unknown. Here we quantified these dynamic equilibria in the β...

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Veröffentlicht in:	Nature communications 2020-05, Vol.11 (1), p.2216
Hauptverfasser:	Grahl, Anne, Abiko, Layara Akemi, Isogai, Shin, Sharpe, Timothy, Grzesiek, Stephan
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Allosteric Regulation Animals Humans Ligands Magnetic Resonance Spectroscopy - methods Models, Molecular Models, Theoretical Protein Binding Protein Conformation Receptors, Adrenergic, beta-1 - chemistry Receptors, Adrenergic, beta-1 - genetics Receptors, Adrenergic, beta-1 - metabolism Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Sf9 Cells Spodoptera
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