Inhibition of cardiac K v 4.3 (I to ) channel isoforms by class I antiarrhythmic drugs lidocaine and mexiletine

Transient outward K current, I , contributes to cardiac action potential generation and is primarily carried by K 4.3 (KCND3) channels. Two K 4.3 isoforms are expressed in human ventricle and show differential remodeling in heart failure (HF). Lidocaine and mexiletine may be applied in selected pati...

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