Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Randomized Clinical Trial

There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the antiviral effect of chloroquine diphosphate (CQ) requires a high concentration of the drug. To evaluate the safety and efficacy of 2 CQ dosages in patients with severe COVID...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	JAMA network open 2020-04, Vol.3 (4), p.e208857
Hauptverfasser:	Borba, Mayla Gabriela Silva, Val, Fernando Fonseca Almeida, Sampaio, Vanderson Souza, Alexandre, Marcia Almeida Araújo, Melo, Gisely Cardoso, Brito, Marcelo, Mourão, Maria Paula Gomes, Brito-Sousa, José Diego, Baía-da-Silva, Djane, Guerra, Marcus Vinitius Farias, Hajjar, Ludhmila Abrahão, Pinto, Rosemary Costa, Balieiro, Antonio Alcirley Silva, Pacheco, Antônio Guilherme Fonseca, Santos, Jr, James Dean Oliveira, Naveca, Felipe Gomes, Xavier, Mariana Simão, Siqueira, André Machado, Schwarzbold, Alexandre, Croda, Júlio, Nogueira, Maurício Lacerda, Romero, Gustavo Adolfo Sierra, Bassat, Quique, Fontes, Cor Jesus, Albuquerque, Bernardino Cláudio, Daniel-Ribeiro, Cláudio-Tadeu, Monteiro, Wuelton Marcelo, Lacerda, Marcus Vinícius Guimarães
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - adverse effects Antiviral Agents - administration & dosage Azithromycin - administration & dosage Betacoronavirus Chemotherapy, Adjuvant Chloroquine - administration & dosage Chloroquine - adverse effects Chloroquine - analogs & derivatives Coronavirus Infections - drug therapy Coronavirus Infections - mortality Coronavirus Infections - physiopathology Female Humans Male Middle Aged Oseltamivir - administration & dosage Pandemics Pneumonia, Viral - drug therapy Pneumonia, Viral - mortality Pneumonia, Viral - physiopathology RNA, Viral Viral Load - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!