Study of doxorubicin photodegradation in plasma, urine and cell culture medium by HPLC

An HPLC method was used to monitor the chemical stability of doxorubicin-HCl (DXR) to light in plasma, urine and cell culture medium at room temperature. The results indicated that DXR was very unstable in cell culture medium and urine when exposed to light. It was more stable in plasma under the sa...

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Veröffentlicht in:	Biomedical chromatography 1988-11, Vol.2 (6), p.242
Hauptverfasser:	Le Bot, M A, Riche, C, Guedes, Y, Kernaleguen, D, Simon, S, Begue, J M, Berthou, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Chromatography, High Pressure Liquid Daunorubicin - analysis Doxorubicin - blood Doxorubicin - metabolism Doxorubicin - radiation effects Doxorubicin - urine Kinetics Photochemistry Reference Standards Spectrometry, Fluorescence
Online-Zugang:	Volltext
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