Ideal pharmacokinetic profile of dotinurad as a selective urate reabsorption inhibitor

Dotinurad, a novel selective urate reabsorption inhibitor (SURI), has potent inhibitory effects at low doses on the uptake of urate by urate transporter 1 (URAT1, solute carrier family 22 member 12 [SLC22A12]), localized at the apical membrane of renal proximal tubular cells. This study sought to cl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Drug metabolism and pharmacokinetics 2020-06, Vol.35 (3), p.313-320
Hauptverfasser:	Omura, Koichi, Miyata, Kengo, Kobashi, Seiichi, Ito, Azusa, Fushimi, Masahiko, Uda, Junichiro, Sasaki, Tomomitsu, Iwanaga, Takashi, Ohashi, Tetsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzothiazoles - administration & dosage Benzothiazoles - blood Benzothiazoles - pharmacokinetics Dose-Response Relationship, Drug Dotinurad Haplorhini Human mass balance study Humans Hyperuricemia Life Sciences & Biomedicine Male Pharmacology & Pharmacy Rats Rats, Sprague-Dawley Science & Technology URAT1 Uric Acid - antagonists & inhibitors Uric Acid - metabolism Uricosuric agent
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!