Modeling Psychiatric Disorder Biology with Stem Cells

Purpose of Review We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and directed cell differentiation. Recent Findings The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibiliti...

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Veröffentlicht in:Current psychiatry reports 2020-04, Vol.22 (5), p.24-24, Article 24
Hauptverfasser: Das, Debamitra, Feuer, Kyra, Wahbeh, Marah, Avramopoulos, Dimitrios
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container_title Current psychiatry reports
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creator Das, Debamitra
Feuer, Kyra
Wahbeh, Marah
Avramopoulos, Dimitrios
description Purpose of Review We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and directed cell differentiation. Recent Findings The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibilities for the study of psychiatric disease. iPSCs can be derived from patients or controls and differentiated to an array of neuronal and non-neuronal cell types. Their genomes can be edited as desired, and they can be assessed for a variety of phenotypes. This makes them especially interesting for studying genetic variation, which is particularly useful today now that our knowledge on the genetics of psychiatric disease is quickly expanding. Summary The recent advances in cell engineering have led to powerful new methods for studying psychiatric illness including schizophrenia, bipolar disorder, and autism. There is a wide array of possible applications as illustrated by the many examples from the literature, most of which are cited here.
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subjects Bipolar Disorder - genetics
Genetic Disorders (F Goes
Humans
Induced Pluripotent Stem Cells
Life Sciences & Biomedicine
Medicine
Medicine & Public Health
Mental disorders
Neurons
Phenotype
Psychiatry
Schizophrenia
Science & Technology
Section Editor
Stem cells
Topical Collection on Genetic Disorders
title Modeling Psychiatric Disorder Biology with Stem Cells
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