Modeling Psychiatric Disorder Biology with Stem Cells
Purpose of Review We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and directed cell differentiation. Recent Findings The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibiliti...
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| Veröffentlicht in: | Current psychiatry reports 2020-04, Vol.22 (5), p.24-24, Article 24 |
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| creator | Das, Debamitra Feuer, Kyra Wahbeh, Marah Avramopoulos, Dimitrios |
| description | Purpose of Review
We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and directed cell differentiation.
Recent Findings
The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibilities for the study of psychiatric disease. iPSCs can be derived from patients or controls and differentiated to an array of neuronal and non-neuronal cell types. Their genomes can be edited as desired, and they can be assessed for a variety of phenotypes. This makes them especially interesting for studying genetic variation, which is particularly useful today now that our knowledge on the genetics of psychiatric disease is quickly expanding.
Summary
The recent advances in cell engineering have led to powerful new methods for studying psychiatric illness including schizophrenia, bipolar disorder, and autism. There is a wide array of possible applications as illustrated by the many examples from the literature, most of which are cited here. |
| doi_str_mv | 10.1007/s11920-020-01148-1 |
| format | Article |
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We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and directed cell differentiation.
Recent Findings
The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibilities for the study of psychiatric disease. iPSCs can be derived from patients or controls and differentiated to an array of neuronal and non-neuronal cell types. Their genomes can be edited as desired, and they can be assessed for a variety of phenotypes. This makes them especially interesting for studying genetic variation, which is particularly useful today now that our knowledge on the genetics of psychiatric disease is quickly expanding.
Summary
The recent advances in cell engineering have led to powerful new methods for studying psychiatric illness including schizophrenia, bipolar disorder, and autism. There is a wide array of possible applications as illustrated by the many examples from the literature, most of which are cited here.</description><identifier>ISSN: 1523-3812</identifier><identifier>ISSN: 1535-1645</identifier><identifier>EISSN: 1535-1645</identifier><identifier>DOI: 10.1007/s11920-020-01148-1</identifier><identifier>PMID: 32318888</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Bipolar Disorder - genetics ; Genetic Disorders (F Goes ; Humans ; Induced Pluripotent Stem Cells ; Life Sciences & Biomedicine ; Medicine ; Medicine & Public Health ; Mental disorders ; Neurons ; Phenotype ; Psychiatry ; Schizophrenia ; Science & Technology ; Section Editor ; Stem cells ; Topical Collection on Genetic Disorders</subject><ispartof>Current psychiatry reports, 2020-04, Vol.22 (5), p.24-24, Article 24</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>17</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000527661600001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c474t-ed2011cdaae128cad0fb903470695e7ed4a9c43ebedb0101c1694aba8636b7f13</citedby><cites>FETCH-LOGICAL-c474t-ed2011cdaae128cad0fb903470695e7ed4a9c43ebedb0101c1694aba8636b7f13</cites><orcidid>0000-0003-3704-6136</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11920-020-01148-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11920-020-01148-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,315,781,785,886,27929,27930,28253,28254,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32318888$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Das, Debamitra</creatorcontrib><creatorcontrib>Feuer, Kyra</creatorcontrib><creatorcontrib>Wahbeh, Marah</creatorcontrib><creatorcontrib>Avramopoulos, Dimitrios</creatorcontrib><title>Modeling Psychiatric Disorder Biology with Stem Cells</title><title>Current psychiatry reports</title><addtitle>Curr Psychiatry Rep</addtitle><addtitle>CURR PSYCHIAT REP</addtitle><addtitle>Curr Psychiatry Rep</addtitle><description>Purpose of Review
We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and directed cell differentiation.
Recent Findings
The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibilities for the study of psychiatric disease. iPSCs can be derived from patients or controls and differentiated to an array of neuronal and non-neuronal cell types. Their genomes can be edited as desired, and they can be assessed for a variety of phenotypes. This makes them especially interesting for studying genetic variation, which is particularly useful today now that our knowledge on the genetics of psychiatric disease is quickly expanding.
Summary
The recent advances in cell engineering have led to powerful new methods for studying psychiatric illness including schizophrenia, bipolar disorder, and autism. There is a wide array of possible applications as illustrated by the many examples from the literature, most of which are cited here.</description><subject>Bipolar Disorder - genetics</subject><subject>Genetic Disorders (F Goes</subject><subject>Humans</subject><subject>Induced Pluripotent Stem Cells</subject><subject>Life Sciences & Biomedicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental disorders</subject><subject>Neurons</subject><subject>Phenotype</subject><subject>Psychiatry</subject><subject>Schizophrenia</subject><subject>Science & Technology</subject><subject>Section Editor</subject><subject>Stem cells</subject><subject>Topical Collection on Genetic Disorders</subject><issn>1523-3812</issn><issn>1535-1645</issn><issn>1535-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ARHDP</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkVuL1TAUhYsozjj6B3yQgi-CdGbn0jR9EbReYURBfQ5puntOhp5kJkkdzr-flI7Hy8NgIGRDvr2yV1ZRPCVwSgCas0hIS6GCZRPCZUXuFcekZnVFBK_vLzVlFZOEHhWPYryATIKkD4sjRhmReR0X9Wc_4GTdpvwa92ZrdQrWlG9t9GHAUL6xfvKbfXlt07b8lnBXdjhN8XHxYNRTxCe350nx4_27793H6vzLh0_d6_PK8IanCgeaBzOD1kioNHqAsW-B8QZEW2ODA9et4Qx7HHogQAwRLde9loKJvhkJOylerbqXc7_DwaBLQU_qMtidDnvltVV_3zi7VRv_U8n8bluLLPDiViD4qxljUjsbTbagHfo5KspaVjdcNjyjz_9BL_wcXLa3UFS2-c9ppuhKmeBjDDgehiGgllTUmoqCZS-pqMXGsz9tHFp-xZCBlytwjb0fo7HoDB4wAKhpIwQRuYJFTv4_3dmkk_Wu87NLuZWtrTHjboPht8k75r8BW5-4OQ</recordid><startdate>20200421</startdate><enddate>20200421</enddate><creator>Das, Debamitra</creator><creator>Feuer, Kyra</creator><creator>Wahbeh, Marah</creator><creator>Avramopoulos, Dimitrios</creator><general>Springer US</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>17B</scope><scope>AOWDO</scope><scope>ARHDP</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3704-6136</orcidid></search><sort><creationdate>20200421</creationdate><title>Modeling Psychiatric Disorder Biology with Stem Cells</title><author>Das, Debamitra ; Feuer, Kyra ; Wahbeh, Marah ; Avramopoulos, Dimitrios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-ed2011cdaae128cad0fb903470695e7ed4a9c43ebedb0101c1694aba8636b7f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bipolar Disorder - genetics</topic><topic>Genetic Disorders (F Goes</topic><topic>Humans</topic><topic>Induced Pluripotent Stem Cells</topic><topic>Life Sciences & Biomedicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental disorders</topic><topic>Neurons</topic><topic>Phenotype</topic><topic>Psychiatry</topic><topic>Schizophrenia</topic><topic>Science & Technology</topic><topic>Section Editor</topic><topic>Stem cells</topic><topic>Topical Collection on Genetic Disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Das, Debamitra</creatorcontrib><creatorcontrib>Feuer, Kyra</creatorcontrib><creatorcontrib>Wahbeh, Marah</creatorcontrib><creatorcontrib>Avramopoulos, Dimitrios</creatorcontrib><collection>Web of Knowledge</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science - Social Sciences Citation Index – 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI & AHCI)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current psychiatry reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Das, Debamitra</au><au>Feuer, Kyra</au><au>Wahbeh, Marah</au><au>Avramopoulos, Dimitrios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modeling Psychiatric Disorder Biology with Stem Cells</atitle><jtitle>Current psychiatry reports</jtitle><stitle>Curr Psychiatry Rep</stitle><stitle>CURR PSYCHIAT REP</stitle><addtitle>Curr Psychiatry Rep</addtitle><date>2020-04-21</date><risdate>2020</risdate><volume>22</volume><issue>5</issue><spage>24</spage><epage>24</epage><pages>24-24</pages><artnum>24</artnum><issn>1523-3812</issn><issn>1535-1645</issn><eissn>1535-1645</eissn><abstract>Purpose of Review
We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and directed cell differentiation.
Recent Findings
The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibilities for the study of psychiatric disease. iPSCs can be derived from patients or controls and differentiated to an array of neuronal and non-neuronal cell types. Their genomes can be edited as desired, and they can be assessed for a variety of phenotypes. This makes them especially interesting for studying genetic variation, which is particularly useful today now that our knowledge on the genetics of psychiatric disease is quickly expanding.
Summary
The recent advances in cell engineering have led to powerful new methods for studying psychiatric illness including schizophrenia, bipolar disorder, and autism. There is a wide array of possible applications as illustrated by the many examples from the literature, most of which are cited here.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32318888</pmid><doi>10.1007/s11920-020-01148-1</doi><tpages>23</tpages><orcidid>https://orcid.org/0000-0003-3704-6136</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Bipolar Disorder - genetics Genetic Disorders (F Goes Humans Induced Pluripotent Stem Cells Life Sciences & Biomedicine Medicine Medicine & Public Health Mental disorders Neurons Phenotype Psychiatry Schizophrenia Science & Technology Section Editor Stem cells Topical Collection on Genetic Disorders |
| title | Modeling Psychiatric Disorder Biology with Stem Cells |
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