Modeling Psychiatric Disorder Biology with Stem Cells

Purpose of Review We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and directed cell differentiation. Recent Findings The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibiliti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Current psychiatry reports 2020-04, Vol.22 (5), p.24-24, Article 24
Hauptverfasser: Das, Debamitra, Feuer, Kyra, Wahbeh, Marah, Avramopoulos, Dimitrios
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 24
container_issue 5
container_start_page 24
container_title Current psychiatry reports
container_volume 22
creator Das, Debamitra
Feuer, Kyra
Wahbeh, Marah
Avramopoulos, Dimitrios
description Purpose of Review We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and directed cell differentiation. Recent Findings The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibilities for the study of psychiatric disease. iPSCs can be derived from patients or controls and differentiated to an array of neuronal and non-neuronal cell types. Their genomes can be edited as desired, and they can be assessed for a variety of phenotypes. This makes them especially interesting for studying genetic variation, which is particularly useful today now that our knowledge on the genetics of psychiatric disease is quickly expanding. Summary The recent advances in cell engineering have led to powerful new methods for studying psychiatric illness including schizophrenia, bipolar disorder, and autism. There is a wide array of possible applications as illustrated by the many examples from the literature, most of which are cited here.
doi_str_mv 10.1007/s11920-020-01148-1
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_32318888</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2393574874</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-ed2011cdaae128cad0fb903470695e7ed4a9c43ebedb0101c1694aba8636b7f13</originalsourceid><addsrcrecordid>eNqNkVuL1TAUhYsozjj6B3yQgi-CdGbn0jR9EbReYURBfQ5puntOhp5kJkkdzr-flI7Hy8NgIGRDvr2yV1ZRPCVwSgCas0hIS6GCZRPCZUXuFcekZnVFBK_vLzVlFZOEHhWPYryATIKkD4sjRhmReR0X9Wc_4GTdpvwa92ZrdQrWlG9t9GHAUL6xfvKbfXlt07b8lnBXdjhN8XHxYNRTxCe350nx4_27793H6vzLh0_d6_PK8IanCgeaBzOD1kioNHqAsW-B8QZEW2ODA9et4Qx7HHogQAwRLde9loKJvhkJOylerbqXc7_DwaBLQU_qMtidDnvltVV_3zi7VRv_U8n8bluLLPDiViD4qxljUjsbTbagHfo5KspaVjdcNjyjz_9BL_wcXLa3UFS2-c9ppuhKmeBjDDgehiGgllTUmoqCZS-pqMXGsz9tHFp-xZCBlytwjb0fo7HoDB4wAKhpIwQRuYJFTv4_3dmkk_Wu87NLuZWtrTHjboPht8k75r8BW5-4OQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2392891002</pqid></control><display><type>article</type><title>Modeling Psychiatric Disorder Biology with Stem Cells</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>Web of Science - Science Citation Index Expanded - 2020&lt;img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /&gt;</source><source>Web of Science - Social Sciences Citation Index – 2020&lt;img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /&gt;</source><creator>Das, Debamitra ; Feuer, Kyra ; Wahbeh, Marah ; Avramopoulos, Dimitrios</creator><creatorcontrib>Das, Debamitra ; Feuer, Kyra ; Wahbeh, Marah ; Avramopoulos, Dimitrios</creatorcontrib><description>Purpose of Review We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and directed cell differentiation. Recent Findings The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibilities for the study of psychiatric disease. iPSCs can be derived from patients or controls and differentiated to an array of neuronal and non-neuronal cell types. Their genomes can be edited as desired, and they can be assessed for a variety of phenotypes. This makes them especially interesting for studying genetic variation, which is particularly useful today now that our knowledge on the genetics of psychiatric disease is quickly expanding. Summary The recent advances in cell engineering have led to powerful new methods for studying psychiatric illness including schizophrenia, bipolar disorder, and autism. There is a wide array of possible applications as illustrated by the many examples from the literature, most of which are cited here.</description><identifier>ISSN: 1523-3812</identifier><identifier>ISSN: 1535-1645</identifier><identifier>EISSN: 1535-1645</identifier><identifier>DOI: 10.1007/s11920-020-01148-1</identifier><identifier>PMID: 32318888</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Bipolar Disorder - genetics ; Genetic Disorders (F Goes ; Humans ; Induced Pluripotent Stem Cells ; Life Sciences &amp; Biomedicine ; Medicine ; Medicine &amp; Public Health ; Mental disorders ; Neurons ; Phenotype ; Psychiatry ; Schizophrenia ; Science &amp; Technology ; Section Editor ; Stem cells ; Topical Collection on Genetic Disorders</subject><ispartof>Current psychiatry reports, 2020-04, Vol.22 (5), p.24-24, Article 24</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>16</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000527661600001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c474t-ed2011cdaae128cad0fb903470695e7ed4a9c43ebedb0101c1694aba8636b7f13</citedby><cites>FETCH-LOGICAL-c474t-ed2011cdaae128cad0fb903470695e7ed4a9c43ebedb0101c1694aba8636b7f13</cites><orcidid>0000-0003-3704-6136</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11920-020-01148-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11920-020-01148-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,315,782,786,887,27931,27932,28255,28256,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32318888$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Das, Debamitra</creatorcontrib><creatorcontrib>Feuer, Kyra</creatorcontrib><creatorcontrib>Wahbeh, Marah</creatorcontrib><creatorcontrib>Avramopoulos, Dimitrios</creatorcontrib><title>Modeling Psychiatric Disorder Biology with Stem Cells</title><title>Current psychiatry reports</title><addtitle>Curr Psychiatry Rep</addtitle><addtitle>CURR PSYCHIAT REP</addtitle><addtitle>Curr Psychiatry Rep</addtitle><description>Purpose of Review We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and directed cell differentiation. Recent Findings The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibilities for the study of psychiatric disease. iPSCs can be derived from patients or controls and differentiated to an array of neuronal and non-neuronal cell types. Their genomes can be edited as desired, and they can be assessed for a variety of phenotypes. This makes them especially interesting for studying genetic variation, which is particularly useful today now that our knowledge on the genetics of psychiatric disease is quickly expanding. Summary The recent advances in cell engineering have led to powerful new methods for studying psychiatric illness including schizophrenia, bipolar disorder, and autism. There is a wide array of possible applications as illustrated by the many examples from the literature, most of which are cited here.</description><subject>Bipolar Disorder - genetics</subject><subject>Genetic Disorders (F Goes</subject><subject>Humans</subject><subject>Induced Pluripotent Stem Cells</subject><subject>Life Sciences &amp; Biomedicine</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Mental disorders</subject><subject>Neurons</subject><subject>Phenotype</subject><subject>Psychiatry</subject><subject>Schizophrenia</subject><subject>Science &amp; Technology</subject><subject>Section Editor</subject><subject>Stem cells</subject><subject>Topical Collection on Genetic Disorders</subject><issn>1523-3812</issn><issn>1535-1645</issn><issn>1535-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ARHDP</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkVuL1TAUhYsozjj6B3yQgi-CdGbn0jR9EbReYURBfQ5puntOhp5kJkkdzr-flI7Hy8NgIGRDvr2yV1ZRPCVwSgCas0hIS6GCZRPCZUXuFcekZnVFBK_vLzVlFZOEHhWPYryATIKkD4sjRhmReR0X9Wc_4GTdpvwa92ZrdQrWlG9t9GHAUL6xfvKbfXlt07b8lnBXdjhN8XHxYNRTxCe350nx4_27793H6vzLh0_d6_PK8IanCgeaBzOD1kioNHqAsW-B8QZEW2ODA9et4Qx7HHogQAwRLde9loKJvhkJOylerbqXc7_DwaBLQU_qMtidDnvltVV_3zi7VRv_U8n8bluLLPDiViD4qxljUjsbTbagHfo5KspaVjdcNjyjz_9BL_wcXLa3UFS2-c9ppuhKmeBjDDgehiGgllTUmoqCZS-pqMXGsz9tHFp-xZCBlytwjb0fo7HoDB4wAKhpIwQRuYJFTv4_3dmkk_Wu87NLuZWtrTHjboPht8k75r8BW5-4OQ</recordid><startdate>20200421</startdate><enddate>20200421</enddate><creator>Das, Debamitra</creator><creator>Feuer, Kyra</creator><creator>Wahbeh, Marah</creator><creator>Avramopoulos, Dimitrios</creator><general>Springer US</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>17B</scope><scope>AOWDO</scope><scope>ARHDP</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3704-6136</orcidid></search><sort><creationdate>20200421</creationdate><title>Modeling Psychiatric Disorder Biology with Stem Cells</title><author>Das, Debamitra ; Feuer, Kyra ; Wahbeh, Marah ; Avramopoulos, Dimitrios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-ed2011cdaae128cad0fb903470695e7ed4a9c43ebedb0101c1694aba8636b7f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bipolar Disorder - genetics</topic><topic>Genetic Disorders (F Goes</topic><topic>Humans</topic><topic>Induced Pluripotent Stem Cells</topic><topic>Life Sciences &amp; Biomedicine</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Mental disorders</topic><topic>Neurons</topic><topic>Phenotype</topic><topic>Psychiatry</topic><topic>Schizophrenia</topic><topic>Science &amp; Technology</topic><topic>Section Editor</topic><topic>Stem cells</topic><topic>Topical Collection on Genetic Disorders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Das, Debamitra</creatorcontrib><creatorcontrib>Feuer, Kyra</creatorcontrib><creatorcontrib>Wahbeh, Marah</creatorcontrib><creatorcontrib>Avramopoulos, Dimitrios</creatorcontrib><collection>Web of Knowledge</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science - Social Sciences Citation Index – 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI &amp; AHCI)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current psychiatry reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Das, Debamitra</au><au>Feuer, Kyra</au><au>Wahbeh, Marah</au><au>Avramopoulos, Dimitrios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modeling Psychiatric Disorder Biology with Stem Cells</atitle><jtitle>Current psychiatry reports</jtitle><stitle>Curr Psychiatry Rep</stitle><stitle>CURR PSYCHIAT REP</stitle><addtitle>Curr Psychiatry Rep</addtitle><date>2020-04-21</date><risdate>2020</risdate><volume>22</volume><issue>5</issue><spage>24</spage><epage>24</epage><pages>24-24</pages><artnum>24</artnum><issn>1523-3812</issn><issn>1535-1645</issn><eissn>1535-1645</eissn><abstract>Purpose of Review We review the ways in which stem cells are used in psychiatric disease research, including the related advances in gene editing and directed cell differentiation. Recent Findings The recent development of induced pluripotent stem cell (iPSC) technologies has created new possibilities for the study of psychiatric disease. iPSCs can be derived from patients or controls and differentiated to an array of neuronal and non-neuronal cell types. Their genomes can be edited as desired, and they can be assessed for a variety of phenotypes. This makes them especially interesting for studying genetic variation, which is particularly useful today now that our knowledge on the genetics of psychiatric disease is quickly expanding. Summary The recent advances in cell engineering have led to powerful new methods for studying psychiatric illness including schizophrenia, bipolar disorder, and autism. There is a wide array of possible applications as illustrated by the many examples from the literature, most of which are cited here.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32318888</pmid><doi>10.1007/s11920-020-01148-1</doi><tpages>23</tpages><orcidid>https://orcid.org/0000-0003-3704-6136</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1523-3812
ispartof Current psychiatry reports, 2020-04, Vol.22 (5), p.24-24, Article 24
issn 1523-3812
1535-1645
1535-1645
language eng
recordid cdi_pubmed_primary_32318888
source MEDLINE; SpringerNature Journals; Web of Science - Science Citation Index Expanded - 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; Web of Science - Social Sciences Citation Index – 2020<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />
subjects Bipolar Disorder - genetics
Genetic Disorders (F Goes
Humans
Induced Pluripotent Stem Cells
Life Sciences & Biomedicine
Medicine
Medicine & Public Health
Mental disorders
Neurons
Phenotype
Psychiatry
Schizophrenia
Science & Technology
Section Editor
Stem cells
Topical Collection on Genetic Disorders
title Modeling Psychiatric Disorder Biology with Stem Cells
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T12%3A02%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Modeling%20Psychiatric%20Disorder%20Biology%20with%20Stem%20Cells&rft.jtitle=Current%20psychiatry%20reports&rft.au=Das,%20Debamitra&rft.date=2020-04-21&rft.volume=22&rft.issue=5&rft.spage=24&rft.epage=24&rft.pages=24-24&rft.artnum=24&rft.issn=1523-3812&rft.eissn=1535-1645&rft_id=info:doi/10.1007/s11920-020-01148-1&rft_dat=%3Cproquest_pubme%3E2393574874%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2392891002&rft_id=info:pmid/32318888&rfr_iscdi=true