Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

T-cell acute lymphoblastic leukemia (T-ALL) and T-cell acute lymphoblastic lymphoma (T-LBL) are aggressive hematological malignancies that are currently treated with high-dose chemotherapy. Over the last several years, the search toward novel and less-toxic therapeutic strategies for T-ALL/T-LBL pat...

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Veröffentlicht in:	Blood 2020-05, Vol.135 (19), p.1685-1695
Hauptverfasser:	De Smedt, Renate, Morscio, Julie, Reunes, Lindy, Roels, Juliette, Bardelli, Valentina, Lintermans, Beatrice, Van Loocke, Wouter, Almeida, Afonso, Cheung, Laurence C., Kotecha, Rishi S., Mansour, Marc R., Uyttebroeck, Anne, Vandenberghe, Peter, La Starza, Roberta, Mecucci, Cristina, Lammens, Tim, Van Roy, Nadine, De Moerloose, Barbara, Barata, João T., Taghon, Tom, Goossens, Steven, Van Vlierberghe, Pieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis Cell Proliferation Cytokines - pharmacology Drug Therapy, Combination Gene Expression Regulation, Neoplastic - drug effects Humans Mice Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology Proto-Oncogene Proteins c-pim-1 - metabolism T-Lymphocytes - drug effects T-Lymphocytes - immunology Tumor Cells, Cultured Xenograft Model Antitumor Assays
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