Typical neurobehavioral methods and transcriptome analysis reveal the neurotoxicity and mechanisms of di(2-ethylhexyl) phthalate on pubertal male ICR mice with type 2 diabetes mellitus

In the present study, the neurotoxicity and mechanisms of di-(2-ethylhexyl) phthalate (DEHP) exposure on pubertal normal (P-normal) and pubertal type 2 diabetes mellitus (P-T2DM) mice were investigated by typical neurobehavioral methods and transcriptome analysis. Pubertal male ICR mice were orally...

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Veröffentlicht in:	Archives of toxicology 2020-04, Vol.94 (4), p.1279-1302
Hauptverfasser:	Feng, Weiwei, Liu, Yongchao, Ding, Yangyang, Mao, Guanghua, Zhao, Ting, Chen, Kun, Qiu, Xuchun, Xu, Tong, Zhao, XiaoFeng, Wu, Xiangyang, Yang, Liuqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Animals Biogenic amines Biomedical and Life Sciences Biomedicine Ca2+/calmodulin-dependent protein kinase II Calcium ions Calcium signalling Cyclic AMP response element-binding protein Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Diethylhexyl Phthalate - toxicity Endocrine Disruptors - toxicity Environmental Health Enzyme-linked immunosorbent assay Exposure Factorial analysis Field tests Gene expression Gene Expression Profiling Kinases Latency Life Sciences & Biomedicine Male Mice Mice, Inbred ICR Nervous system Nervous System - drug effects Nervous System - metabolism Neurotoxicity Neurotoxicity Syndromes Neurotransmitters Occupational Medicine/Industrial Medicine Open-field behavior Organ Toxicity and Mechanisms Pharmacology/Toxicology Phosphorylation Phthalates Phthalic Acids Protein kinase A Science & Technology Signal transduction Signaling Toxicology Western blotting γ-Aminobutyric acid
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