Pisum sativum Defensin 1 Eradicates Mouse Metastatic Lung Nodules from B16F10 Melanoma Cells

Psd1 is a pea plant defensin which can be actively expressed in Pichia pastoris and shows broad antifungal activity. This activity is dependent on fungal membrane glucosylceramide (GlcCer), which is also important for its internalization, nuclear localization, and endoreduplication. Certain cancer c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular sciences 2020-04, Vol.21 (8), p.2662, Article 2662
Hauptverfasser:	Grancieri do Amaral, Virginia Sara, Cristina Silva Santos, Stephanie Alexia, de Andrade, Paula Cavalcante, Nowatzki, Jenifer, Silva Junior, Nilton, de Medeiros, Luciano Neves, Gitirana, Lycia Brito, Pascutti, Pedro Geraldo, Almeida, Vitor H., Monteiro, Robson Q., Kurtenbach, Eleonora
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-metastatic activity Antifungal activity Antimicrobial agents Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Biochemistry & Molecular Biology Biopsy Cell cycle Cell Line Cell Membrane Permeability Cell Proliferation - drug effects Chemistry Chemistry, Multidisciplinary cyclin F Cytotoxicity Defensins - chemistry Defensins - pharmacology Disease Models, Animal Endoreduplication Female Fluorescein Fluorescein isothiocyanate Fluorescent Antibody Technique Fungicides Genomes glucosylceramide (GlcCer) Glucosylceramides - metabolism Immunohistochemistry Inflammation Internalization Intravenous administration Life Sciences & Biomedicine Lipid metabolism Lipids Localization Lung Neoplasms - drug therapy Lung Neoplasms - pathology Lung Neoplasms - secondary Lung nodules Lungs Mammals Melanoma Melanoma, Experimental Membranes Metastases Metastasis metastasis model of B16F10 melanoma Mice Models, Molecular Nodules Nuclei (cytology) Peptides Physical Sciences Pisum sativum - chemistry Pisum sativum defensin 1 (Psd1) Plant Proteins - chemistry Plant Proteins - pharmacology Protein Conformation Science & Technology Skin cancer Structure-Activity Relationship Weight loss
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!