Sequence isomerism in uniform polyphosphoesters programmes self-assembly and folding

Sequence isomerism in uniform polyphosphoesters programmes self-assembly and folding

We have adapted solid phase phosphoramidite synthesis commonly used to make DNA, to produce two sequence-isomeric non-biological polymers which display sequence-programmed folding and self-assembly, going beyond structures which would be trivially anticipated. These findings open up possibilities fo...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-05, Vol.56 (39), p.537-531
Hauptverfasser: Appukutti, Nadeema, Jones, Joseph R, Serpell, Christopher J
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Sprache:eng
Schlagworte:
Folding
Light scattering
Self-assembly
Solid phases
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container_title Chemical communications (Cambridge, England)
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creator Appukutti, Nadeema
Jones, Joseph R
Serpell, Christopher J
description We have adapted solid phase phosphoramidite synthesis commonly used to make DNA, to produce two sequence-isomeric non-biological polymers which display sequence-programmed folding and self-assembly, going beyond structures which would be trivially anticipated. These findings open up possibilities for more sophisticated sequence/structure relationships using the same synthetic platform. Perfectly sequence-defined macromolecules have been synthesised through the phosphoramidite method. Sequence isomerism determines self-assembly giving a raft of unusual nanostructures.
doi_str_mv 10.1039/d0cc01319f
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source Royal Society Of Chemistry Journals; Alma/SFX Local Collection
subjects Folding
Light scattering
Self-assembly
Solid phases
title Sequence isomerism in uniform polyphosphoesters programmes self-assembly and folding
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