Default Mode Network Efficiency Is Correlated With Deficits in Inhibition in Adolescents With Inhalant Use Disorder
It is well established that alterations in cognitive function and damage to brain structures are often found in adolescents who have substance use disorder (SUD). However, deficits in executive cognitive functioning in adolescents related to the vulnerability and consumption of such substances are n...
Gespeichert in:
| Veröffentlicht in: | Frontiers in psychiatry 2020-03, Vol.11, p.209-209, Article 209 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 209 |
|---|---|
| container_issue | |
| container_start_page | 209 |
| container_title | Frontiers in psychiatry |
| container_volume | 11 |
| creator | Hernandez-Alvarez, Dailett M. Pacheco, Lucero Velasco-Segura, Roberto Perez de la Mora, Miguel Tejeda-Romero, Claudia Gonzalez-Garcia, Nadia |
| description | It is well established that alterations in cognitive function and damage to brain structures are often found in adolescents who have substance use disorder (SUD). However, deficits in executive cognitive functioning in adolescents related to the vulnerability and consumption of such substances are not well known. In this study, we use graph theoretic analysis to compare the network efficiency in the resting state for three networks-default mode network (DMN), salience network (SN) and fronto-parietal network (FPN)-between inhalant-consuming adolescents and a control group (12 to 17 years old). We analyzed whether the efficiency of these functional networks was related to working memory, mental flexibility, inhibition of response, and sequential planning. We found that, when compared to the control group, inhalant-consuming adolescents presented with important deficits in communication among brain regions that comprise the DMN, SN, and FPN networks. DMN is the most affected network by inhalant abuse during adolescence. The mediation analyses suggested that the relationship between inhalant abuse and inhibitory control and sequential planning was partly mediated by DMN efficiency. |
| doi_str_mv | 10.3389/fpsyt.2020.00209 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_32273856</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_402869f2671b4a1086ab4c13eb0fb6a7</doaj_id><sourcerecordid>2388831106</sourcerecordid><originalsourceid>FETCH-LOGICAL-c462t-485d6fcab4b84c2461c1be002964ecea03fefed2bf03e20bbc3cac281c6f4ba23</originalsourceid><addsrcrecordid>eNqNUk1v1DAQjRCIVqV3TshHJLSLv-J1LkhVWmClAhcqjpbtjLsu2XixnVb773GyZdXe8MFf896bsd9U1VuCl4zJ5qPbpX1eUkzxEpepeVGdEiH4AguOXz7Zn1TnKd3hMljTMFG_rk4YpSsma3FapUtweuwz-hY6QN8hP4T4G105562Hwe7ROqE2xAi9ztChXz5vUKGUaE7ID2g9bLzx2YdhOl10oYdkYSjBGVrCutdDRjcJ0KVPIXYQ31SvnO4TnD-uZ9XN56uf7dfF9Y8v6_biemG5oHnBZd0JZ7XhRnJLuSCWGChPbQQHCxozBw46ahxmQLExllltqSRWOG40ZWfV-qDbBX2ndtFvddyroL2aL0K8VTpmb3tQHFMpGkfFihiuCZaipLWEgcHOCL0qWp8OWrvRbKGbnhh1_0z0eWTwG3Ub7tWKkOLWVMz7R4EY_oyQstr68lN9-R0IY1KUSSkZIVgUKD5AbQwpRXDHNASryXo1W68m69VsfaG8e1rekfDP6AKQB8ADmODSbC4cYaU3alqLuiFTm5DWZz1Z2oZxyIX64f-p7C_cZ83_</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2388831106</pqid></control><display><type>article</type><title>Default Mode Network Efficiency Is Correlated With Deficits in Inhibition in Adolescents With Inhalant Use Disorder</title><source>PubMed Central Free</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Hernandez-Alvarez, Dailett M. ; Pacheco, Lucero ; Velasco-Segura, Roberto ; Perez de la Mora, Miguel ; Tejeda-Romero, Claudia ; Gonzalez-Garcia, Nadia</creator><creatorcontrib>Hernandez-Alvarez, Dailett M. ; Pacheco, Lucero ; Velasco-Segura, Roberto ; Perez de la Mora, Miguel ; Tejeda-Romero, Claudia ; Gonzalez-Garcia, Nadia</creatorcontrib><description>It is well established that alterations in cognitive function and damage to brain structures are often found in adolescents who have substance use disorder (SUD). However, deficits in executive cognitive functioning in adolescents related to the vulnerability and consumption of such substances are not well known. In this study, we use graph theoretic analysis to compare the network efficiency in the resting state for three networks-default mode network (DMN), salience network (SN) and fronto-parietal network (FPN)-between inhalant-consuming adolescents and a control group (12 to 17 years old). We analyzed whether the efficiency of these functional networks was related to working memory, mental flexibility, inhibition of response, and sequential planning. We found that, when compared to the control group, inhalant-consuming adolescents presented with important deficits in communication among brain regions that comprise the DMN, SN, and FPN networks. DMN is the most affected network by inhalant abuse during adolescence. The mediation analyses suggested that the relationship between inhalant abuse and inhibitory control and sequential planning was partly mediated by DMN efficiency.</description><identifier>ISSN: 1664-0640</identifier><identifier>EISSN: 1664-0640</identifier><identifier>DOI: 10.3389/fpsyt.2020.00209</identifier><identifier>PMID: 32273856</identifier><language>eng</language><publisher>LAUSANNE: Frontiers Media Sa</publisher><subject>adolescents ; executive-function ; functional connectivity ; Life Sciences & Biomedicine ; Psychiatry ; resting-state functional magnetic resonance imaging ; Science & Technology ; substance use disorder</subject><ispartof>Frontiers in psychiatry, 2020-03, Vol.11, p.209-209, Article 209</ispartof><rights>Copyright © 2020 Hernández-Álvarez, Pacheco, Velasco-Segura, Pérez de la Mora, Tejeda-Romero and González-García.</rights><rights>Copyright © 2020 Hernández-Álvarez, Pacheco, Velasco-Segura, Pérez de la Mora, Tejeda-Romero and González-García 2020 Hernández-Álvarez, Pacheco, Velasco-Segura, Pérez de la Mora, Tejeda-Romero and González-García</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>5</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000525659100001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c462t-485d6fcab4b84c2461c1be002964ecea03fefed2bf03e20bbc3cac281c6f4ba23</citedby><cites>FETCH-LOGICAL-c462t-485d6fcab4b84c2461c1be002964ecea03fefed2bf03e20bbc3cac281c6f4ba23</cites><orcidid>0000-0003-0526-1595 ; 0000-0002-8345-2832 ; 0000-0003-1520-4439</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113382/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113382/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2114,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32273856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hernandez-Alvarez, Dailett M.</creatorcontrib><creatorcontrib>Pacheco, Lucero</creatorcontrib><creatorcontrib>Velasco-Segura, Roberto</creatorcontrib><creatorcontrib>Perez de la Mora, Miguel</creatorcontrib><creatorcontrib>Tejeda-Romero, Claudia</creatorcontrib><creatorcontrib>Gonzalez-Garcia, Nadia</creatorcontrib><title>Default Mode Network Efficiency Is Correlated With Deficits in Inhibition in Adolescents With Inhalant Use Disorder</title><title>Frontiers in psychiatry</title><addtitle>FRONT PSYCHIATRY</addtitle><addtitle>Front Psychiatry</addtitle><description>It is well established that alterations in cognitive function and damage to brain structures are often found in adolescents who have substance use disorder (SUD). However, deficits in executive cognitive functioning in adolescents related to the vulnerability and consumption of such substances are not well known. In this study, we use graph theoretic analysis to compare the network efficiency in the resting state for three networks-default mode network (DMN), salience network (SN) and fronto-parietal network (FPN)-between inhalant-consuming adolescents and a control group (12 to 17 years old). We analyzed whether the efficiency of these functional networks was related to working memory, mental flexibility, inhibition of response, and sequential planning. We found that, when compared to the control group, inhalant-consuming adolescents presented with important deficits in communication among brain regions that comprise the DMN, SN, and FPN networks. DMN is the most affected network by inhalant abuse during adolescence. The mediation analyses suggested that the relationship between inhalant abuse and inhibitory control and sequential planning was partly mediated by DMN efficiency.</description><subject>adolescents</subject><subject>executive-function</subject><subject>functional connectivity</subject><subject>Life Sciences & Biomedicine</subject><subject>Psychiatry</subject><subject>resting-state functional magnetic resonance imaging</subject><subject>Science & Technology</subject><subject>substance use disorder</subject><issn>1664-0640</issn><issn>1664-0640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ARHDP</sourceid><sourceid>DOA</sourceid><recordid>eNqNUk1v1DAQjRCIVqV3TshHJLSLv-J1LkhVWmClAhcqjpbtjLsu2XixnVb773GyZdXe8MFf896bsd9U1VuCl4zJ5qPbpX1eUkzxEpepeVGdEiH4AguOXz7Zn1TnKd3hMljTMFG_rk4YpSsma3FapUtweuwz-hY6QN8hP4T4G105562Hwe7ROqE2xAi9ztChXz5vUKGUaE7ID2g9bLzx2YdhOl10oYdkYSjBGVrCutdDRjcJ0KVPIXYQ31SvnO4TnD-uZ9XN56uf7dfF9Y8v6_biemG5oHnBZd0JZ7XhRnJLuSCWGChPbQQHCxozBw46ahxmQLExllltqSRWOG40ZWfV-qDbBX2ndtFvddyroL2aL0K8VTpmb3tQHFMpGkfFihiuCZaipLWEgcHOCL0qWp8OWrvRbKGbnhh1_0z0eWTwG3Ub7tWKkOLWVMz7R4EY_oyQstr68lN9-R0IY1KUSSkZIVgUKD5AbQwpRXDHNASryXo1W68m69VsfaG8e1rekfDP6AKQB8ADmODSbC4cYaU3alqLuiFTm5DWZz1Z2oZxyIX64f-p7C_cZ83_</recordid><startdate>20200326</startdate><enddate>20200326</enddate><creator>Hernandez-Alvarez, Dailett M.</creator><creator>Pacheco, Lucero</creator><creator>Velasco-Segura, Roberto</creator><creator>Perez de la Mora, Miguel</creator><creator>Tejeda-Romero, Claudia</creator><creator>Gonzalez-Garcia, Nadia</creator><general>Frontiers Media Sa</general><general>Frontiers Media S.A</general><scope>17B</scope><scope>AOWDO</scope><scope>ARHDP</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0526-1595</orcidid><orcidid>https://orcid.org/0000-0002-8345-2832</orcidid><orcidid>https://orcid.org/0000-0003-1520-4439</orcidid></search><sort><creationdate>20200326</creationdate><title>Default Mode Network Efficiency Is Correlated With Deficits in Inhibition in Adolescents With Inhalant Use Disorder</title><author>Hernandez-Alvarez, Dailett M. ; Pacheco, Lucero ; Velasco-Segura, Roberto ; Perez de la Mora, Miguel ; Tejeda-Romero, Claudia ; Gonzalez-Garcia, Nadia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-485d6fcab4b84c2461c1be002964ecea03fefed2bf03e20bbc3cac281c6f4ba23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>adolescents</topic><topic>executive-function</topic><topic>functional connectivity</topic><topic>Life Sciences & Biomedicine</topic><topic>Psychiatry</topic><topic>resting-state functional magnetic resonance imaging</topic><topic>Science & Technology</topic><topic>substance use disorder</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hernandez-Alvarez, Dailett M.</creatorcontrib><creatorcontrib>Pacheco, Lucero</creatorcontrib><creatorcontrib>Velasco-Segura, Roberto</creatorcontrib><creatorcontrib>Perez de la Mora, Miguel</creatorcontrib><creatorcontrib>Tejeda-Romero, Claudia</creatorcontrib><creatorcontrib>Gonzalez-Garcia, Nadia</creatorcontrib><collection>Web of Knowledge</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science - Social Sciences Citation Index – 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Social Sciences Citation Index</collection><collection>Web of Science Primary (SCIE, SSCI & AHCI)</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hernandez-Alvarez, Dailett M.</au><au>Pacheco, Lucero</au><au>Velasco-Segura, Roberto</au><au>Perez de la Mora, Miguel</au><au>Tejeda-Romero, Claudia</au><au>Gonzalez-Garcia, Nadia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Default Mode Network Efficiency Is Correlated With Deficits in Inhibition in Adolescents With Inhalant Use Disorder</atitle><jtitle>Frontiers in psychiatry</jtitle><stitle>FRONT PSYCHIATRY</stitle><addtitle>Front Psychiatry</addtitle><date>2020-03-26</date><risdate>2020</risdate><volume>11</volume><spage>209</spage><epage>209</epage><pages>209-209</pages><artnum>209</artnum><issn>1664-0640</issn><eissn>1664-0640</eissn><abstract>It is well established that alterations in cognitive function and damage to brain structures are often found in adolescents who have substance use disorder (SUD). However, deficits in executive cognitive functioning in adolescents related to the vulnerability and consumption of such substances are not well known. In this study, we use graph theoretic analysis to compare the network efficiency in the resting state for three networks-default mode network (DMN), salience network (SN) and fronto-parietal network (FPN)-between inhalant-consuming adolescents and a control group (12 to 17 years old). We analyzed whether the efficiency of these functional networks was related to working memory, mental flexibility, inhibition of response, and sequential planning. We found that, when compared to the control group, inhalant-consuming adolescents presented with important deficits in communication among brain regions that comprise the DMN, SN, and FPN networks. DMN is the most affected network by inhalant abuse during adolescence. The mediation analyses suggested that the relationship between inhalant abuse and inhibitory control and sequential planning was partly mediated by DMN efficiency.</abstract><cop>LAUSANNE</cop><pub>Frontiers Media Sa</pub><pmid>32273856</pmid><doi>10.3389/fpsyt.2020.00209</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0526-1595</orcidid><orcidid>https://orcid.org/0000-0002-8345-2832</orcidid><orcidid>https://orcid.org/0000-0003-1520-4439</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1664-0640 |
| ispartof | Frontiers in psychiatry, 2020-03, Vol.11, p.209-209, Article 209 |
| issn | 1664-0640 1664-0640 |
| language | eng |
| recordid | cdi_pubmed_primary_32273856 |
| source | PubMed Central Free; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals |
| subjects | adolescents executive-function functional connectivity Life Sciences & Biomedicine Psychiatry resting-state functional magnetic resonance imaging Science & Technology substance use disorder |
| title | Default Mode Network Efficiency Is Correlated With Deficits in Inhibition in Adolescents With Inhalant Use Disorder |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T10%3A14%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Default%20Mode%20Network%20Efficiency%20Is%20Correlated%20With%20Deficits%20in%20Inhibition%20in%20Adolescents%20With%20Inhalant%20Use%20Disorder&rft.jtitle=Frontiers%20in%20psychiatry&rft.au=Hernandez-Alvarez,%20Dailett%20M.&rft.date=2020-03-26&rft.volume=11&rft.spage=209&rft.epage=209&rft.pages=209-209&rft.artnum=209&rft.issn=1664-0640&rft.eissn=1664-0640&rft_id=info:doi/10.3389/fpsyt.2020.00209&rft_dat=%3Cproquest_pubme%3E2388831106%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2388831106&rft_id=info:pmid/32273856&rft_doaj_id=oai_doaj_org_article_402869f2671b4a1086ab4c13eb0fb6a7&rfr_iscdi=true |