Anxiolytic-like effects of mirogabalin, a novel ligand for α 2 δ ligand of voltage-gated calcium channels, in rats repeatedly injected with acidic saline intramuscularly, as an experimental model of fibromyalgia

Mental disorders including anxiety and depression are common comorbidities in fibromyalgia patients, and exert a profound impact on their quality of life. Mirogabalin, a novel ligand for the α δ-subunit of voltage-gated calcium channels, shows analgesic effects in fibromyalgia and neuropathic pain m...

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Veröffentlicht in:	Pharmacological reports 2020-06, Vol.72 (3), p.571
Hauptverfasser:	Murasawa, Hiroyasu, Kobayashi, Hiroyuki, Yasuda, Shun-Ichi, Saeki, Kensuke, Domon, Yuki, Arakawa, Naohisa, Kubota, Kazufumi, Kitano, Yutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology Anxiety - drug therapy Bridged Bicyclo Compounds - pharmacology Calcium Channels, L-Type Elevated Plus Maze Test Fibromyalgia - chemically induced Fibromyalgia - drug therapy Male Neuralgia - drug therapy Open Field Test Pain Threshold - drug effects Rats Rats, Sprague-Dawley
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